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Article: Prophylaxis of post-appendicectomy sepsis by metronidazole and ampicillin: A randomized, prospective and double-blind trial

TitleProphylaxis of post-appendicectomy sepsis by metronidazole and ampicillin: A randomized, prospective and double-blind trial
Authors
Issue Date1983
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uk
Citation
British Journal Of Surgery, 1983, v. 70 n. 3, p. 155-157 How to Cite?
AbstractTwo hundred and eighty-three patients were admitted to a randomized, prospective and double-blind trial of the effect of the addition of ampicillin to metronidazole in the prophylaxis of post-appendicectomy wound sepsis. Nineteen out of 142 patients in the metronidazole and ampicillin group developed wound sepsis compared with 33 out of 141 patients in the metronidazole group. The difference is statistically significant. Early cases, including normal, acutely inflamed and gangrenous appendices, received 2 doses of antibiotics. In late cases with perforation and abscess formation, the antibiotics were continued for 1 week. The difference in wound infection in each of these 2 subgroups was also statistically significant. The commonest organisms isolated from the appendicular fossa and the infected wounds were Eschericia coli and Bacteroides fragilis.
Persistent Identifierhttp://hdl.handle.net/10722/172522
ISSN
2015 Impact Factor: 5.596
2015 SCImago Journal Rankings: 2.966
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, WYen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorYiu, TFen_US
dc.contributor.authorWong, SHen_US
dc.date.accessioned2012-10-30T06:23:14Z-
dc.date.available2012-10-30T06:23:14Z-
dc.date.issued1983en_US
dc.identifier.citationBritish Journal Of Surgery, 1983, v. 70 n. 3, p. 155-157en_US
dc.identifier.issn0007-1323en_US
dc.identifier.urihttp://hdl.handle.net/10722/172522-
dc.description.abstractTwo hundred and eighty-three patients were admitted to a randomized, prospective and double-blind trial of the effect of the addition of ampicillin to metronidazole in the prophylaxis of post-appendicectomy wound sepsis. Nineteen out of 142 patients in the metronidazole and ampicillin group developed wound sepsis compared with 33 out of 141 patients in the metronidazole group. The difference is statistically significant. Early cases, including normal, acutely inflamed and gangrenous appendices, received 2 doses of antibiotics. In late cases with perforation and abscess formation, the antibiotics were continued for 1 week. The difference in wound infection in each of these 2 subgroups was also statistically significant. The commonest organisms isolated from the appendicular fossa and the infected wounds were Eschericia coli and Bacteroides fragilis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.bjs.co.uken_US
dc.relation.ispartofBritish Journal of Surgeryen_US
dc.subject.meshAmpicillin - Therapeutic Useen_US
dc.subject.meshAppendectomyen_US
dc.subject.meshBacterial Infections - Prevention & Controlen_US
dc.subject.meshBacteroides Infections - Prevention & Controlen_US
dc.subject.meshBacteroides Fragilisen_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEscherichia Coli Infections - Prevention & Controlen_US
dc.subject.meshHumansen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshSurgical Wound Infection - Prevention & Controlen_US
dc.titleProphylaxis of post-appendicectomy sepsis by metronidazole and ampicillin: A randomized, prospective and double-blind trialen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bjs.1800700306-
dc.identifier.pmid6338990-
dc.identifier.scopuseid_2-s2.0-0020681209en_US
dc.identifier.volume70en_US
dc.identifier.issue3en_US
dc.identifier.spage155en_US
dc.identifier.epage157en_US
dc.identifier.isiWOS:A1983QH63200005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridYiu, TF=36887055400en_US
dc.identifier.scopusauthoridWong, SH=7404589558en_US

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