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- Publisher Website: 10.1111/j.1525-1438.2006.00835.x
- Scopus: eid_2-s2.0-34248331276
- PMID: 17504376
- WOS: WOS:000246429600010
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Article: Human papillomavirus detection in self-collected vaginal specimens and matched clinician-collected cervical specimens
Title | Human papillomavirus detection in self-collected vaginal specimens and matched clinician-collected cervical specimens |
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Authors | |
Keywords | Cervical cancer Cervical specimen Human papillomavirus Patient acceptance Self-collected specimen Vaginal specimen |
Issue Date | 2007 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/ |
Citation | International Journal Of Gynecological Cancer, 2007, v. 17 n. 3, p. 615-622 How to Cite? |
Abstract | Human papillomavirus (HPV) detection is an integral part of cervical cancer screening, and a range of specimen collection procedures are being tested. Preliminary studies have found that the majority of women prefer self-collection of vaginal specimens instead of clinician-collected specimens of the cervix. The purposes of the current study were to explore the social and behavioral predictors of acceptance of self-collection of vaginal specimens among patients and to assess concordance in detection of HPV between clinician-collected cervical specimens and self-collected vaginal specimens. The study was conducted at a university family medicine clinic using a cross-sectional study design, and enrollment of women presenting for routine gynecological examination consecutively in a period of 1 year, self-administered questionnaires, collection of paired vaginal and cervical specimens for HPV DNA using Hybrid Capture 2, and cytologic analysis. Most women (79.8% [398/499]) agreed to collect vaginal specimens. In our study, 76.6% (216/282) African American women (AA), 88.1% (156/176) white non-Hispanic (WNH) women, and 63.4% (26/41) women of other races (P < 0.0001) agreed to self-collect vaginal specimens. HPV was detected in 16.0% (80/499) of clinician-collected cervical specimens and 26.1% (104/398) of self-collected vaginal specimens (P < 0.001). HPV detection was concordant in 13.4% (53/398) women in both cervical and vaginal specimens. Self-collection of vaginal specimens for HPV DNA detection is acceptable to most women presenting for routine gynecological examination. WNH women were more likely to obtain self-collected specimens than AA women. Vaginal specimens were more likely to be positive for HPV than were cervical specimens. © 2007, IGCS and ESGO. |
Persistent Identifier | http://hdl.handle.net/10722/172434 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.107 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khanna, N | en_US |
dc.contributor.author | Mishra, SI | en_US |
dc.contributor.author | Tian, G | en_US |
dc.contributor.author | Tan, MT | en_US |
dc.contributor.author | Arnold, S | en_US |
dc.contributor.author | Lee, C | en_US |
dc.contributor.author | Ramachandran, S | en_US |
dc.contributor.author | Bell, L | en_US |
dc.contributor.author | Baquet, CR | en_US |
dc.contributor.author | Lorincz, A | en_US |
dc.date.accessioned | 2012-10-30T06:22:31Z | - |
dc.date.available | 2012-10-30T06:22:31Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | International Journal Of Gynecological Cancer, 2007, v. 17 n. 3, p. 615-622 | en_US |
dc.identifier.issn | 1048-891X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172434 | - |
dc.description.abstract | Human papillomavirus (HPV) detection is an integral part of cervical cancer screening, and a range of specimen collection procedures are being tested. Preliminary studies have found that the majority of women prefer self-collection of vaginal specimens instead of clinician-collected specimens of the cervix. The purposes of the current study were to explore the social and behavioral predictors of acceptance of self-collection of vaginal specimens among patients and to assess concordance in detection of HPV between clinician-collected cervical specimens and self-collected vaginal specimens. The study was conducted at a university family medicine clinic using a cross-sectional study design, and enrollment of women presenting for routine gynecological examination consecutively in a period of 1 year, self-administered questionnaires, collection of paired vaginal and cervical specimens for HPV DNA using Hybrid Capture 2, and cytologic analysis. Most women (79.8% [398/499]) agreed to collect vaginal specimens. In our study, 76.6% (216/282) African American women (AA), 88.1% (156/176) white non-Hispanic (WNH) women, and 63.4% (26/41) women of other races (P < 0.0001) agreed to self-collect vaginal specimens. HPV was detected in 16.0% (80/499) of clinician-collected cervical specimens and 26.1% (104/398) of self-collected vaginal specimens (P < 0.001). HPV detection was concordant in 13.4% (53/398) women in both cervical and vaginal specimens. Self-collection of vaginal specimens for HPV DNA detection is acceptable to most women presenting for routine gynecological examination. WNH women were more likely to obtain self-collected specimens than AA women. Vaginal specimens were more likely to be positive for HPV than were cervical specimens. © 2007, IGCS and ESGO. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/ | en_US |
dc.relation.ispartof | International Journal of Gynecological Cancer | en_US |
dc.subject | Cervical cancer | - |
dc.subject | Cervical specimen | - |
dc.subject | Human papillomavirus | - |
dc.subject | Patient acceptance | - |
dc.subject | Self-collected specimen | - |
dc.subject | Vaginal specimen | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Alphapapillomavirus - Genetics - Isolation & Purification | en_US |
dc.subject.mesh | Cervical Intraepithelial Neoplasia - Diagnosis - Virology | en_US |
dc.subject.mesh | Cervix Uteri - Pathology - Virology | en_US |
dc.subject.mesh | Dna Probes, Hpv - Analysis | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Matched-Pair Analysis | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Models, Biological | en_US |
dc.subject.mesh | Patient Acceptance Of Health Care | en_US |
dc.subject.mesh | Specimen Handling - Methods | en_US |
dc.subject.mesh | Uterine Cervical Neoplasms - Diagnosis - Virology | en_US |
dc.subject.mesh | Vaginal Smears - Methods | en_US |
dc.title | Human papillomavirus detection in self-collected vaginal specimens and matched clinician-collected cervical specimens | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tian, G: gltian@hku.hk | en_US |
dc.identifier.authority | Tian, G=rp00789 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1525-1438.2006.00835.x | en_US |
dc.identifier.pmid | 17504376 | - |
dc.identifier.scopus | eid_2-s2.0-34248331276 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34248331276&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 615 | en_US |
dc.identifier.epage | 622 | en_US |
dc.identifier.isi | WOS:000246429600010 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Khanna, N=7102045387 | en_US |
dc.identifier.scopusauthorid | Mishra, SI=7402725393 | en_US |
dc.identifier.scopusauthorid | Tian, G=25621549400 | en_US |
dc.identifier.scopusauthorid | Tan, MT=7401464906 | en_US |
dc.identifier.scopusauthorid | Arnold, S=16306625900 | en_US |
dc.identifier.scopusauthorid | Lee, C=8366194200 | en_US |
dc.identifier.scopusauthorid | Ramachandran, S=16307767600 | en_US |
dc.identifier.scopusauthorid | Bell, L=8631251400 | en_US |
dc.identifier.scopusauthorid | Baquet, CR=6603799789 | en_US |
dc.identifier.scopusauthorid | Lorincz, A=7102379837 | en_US |
dc.identifier.citeulike | 1297689 | - |
dc.identifier.issnl | 1048-891X | - |