File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Human bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall function

TitleHuman bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall function
Authors
Issue Date2006
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2006, v. 177 n. 10, p. 6730-6737 How to Cite?
AbstractThe role of human bone marrow (BM) CD8 + T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 + T cell population (T EM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived T EM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM T EM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the T EM subset in PB, BM CD8 + T EM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific T EM with great therapeutic potential in vaccine development. Copyright © 2006 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/172427
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Xen_US
dc.contributor.authorDong, Hen_US
dc.contributor.authorLin, Wen_US
dc.contributor.authorVoss, Sen_US
dc.contributor.authorHinkley, Len_US
dc.contributor.authorWestergren, Men_US
dc.contributor.authorTian, Gen_US
dc.contributor.authorBerry, Den_US
dc.contributor.authorLewellen, Den_US
dc.contributor.authorVile, RGen_US
dc.contributor.authorChen, Len_US
dc.contributor.authorFarber, DLen_US
dc.contributor.authorStrome, SEen_US
dc.date.accessioned2012-10-30T06:22:28Z-
dc.date.available2012-10-30T06:22:28Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Immunology, 2006, v. 177 n. 10, p. 6730-6737en_US
dc.identifier.issn0022-1767en_US
dc.identifier.urihttp://hdl.handle.net/10722/172427-
dc.description.abstractThe role of human bone marrow (BM) CD8 + T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 + T cell population (T EM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived T EM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM T EM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the T EM subset in PB, BM CD8 + T EM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific T EM with great therapeutic potential in vaccine development. Copyright © 2006 by The American Association of Immunologists, Inc.en_US
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Viral - Immunologyen_US
dc.subject.meshBone Marrow Cells - Cytology - Immunology - Metabolism - Virologyen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Cytology - Immunology - Metabolism - Virologyen_US
dc.subject.meshCytomegalovirus - Immunologyen_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshEpitopes, T-Lymphocyte - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunologic Memoryen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshLeukocytes, Mononuclear - Cytology - Immunologyen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Chemokine - Biosynthesisen_US
dc.titleHuman bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall functionen_US
dc.typeArticleen_US
dc.identifier.emailTian, G: gltian@hku.hken_US
dc.identifier.authorityTian, G=rp00789en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.177.10.6730-
dc.identifier.pmid17082586-
dc.identifier.scopuseid_2-s2.0-33750825269en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750825269&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume177en_US
dc.identifier.issue10en_US
dc.identifier.spage6730en_US
dc.identifier.epage6737en_US
dc.identifier.isiWOS:000242009700021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, X=8281363400en_US
dc.identifier.scopusauthoridDong, H=7402334840en_US
dc.identifier.scopusauthoridLin, W=36068291300en_US
dc.identifier.scopusauthoridVoss, S=26028199600en_US
dc.identifier.scopusauthoridHinkley, L=6602924820en_US
dc.identifier.scopusauthoridWestergren, M=15058381100en_US
dc.identifier.scopusauthoridTian, G=25621549400en_US
dc.identifier.scopusauthoridBerry, D=55065696800en_US
dc.identifier.scopusauthoridLewellen, D=15057757700en_US
dc.identifier.scopusauthoridVile, RG=7006170387en_US
dc.identifier.scopusauthoridChen, L=7409444112en_US
dc.identifier.scopusauthoridFarber, DL=35576751000en_US
dc.identifier.scopusauthoridStrome, SE=7004882323en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats