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Article: Combining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers

TitleCombining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers
Authors
KeywordsCase-Control
Linkage Disequilibrium (Ld)
Multiallelic Marker
Transmission/Disequilibrium Test (Tdt)
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhg
Citation
European Journal Of Human Genetics, 2005, v. 13 n. 9, p. 1007-1012 How to Cite?
AbstractCase-control studies compare marker-allele distributions in affected and unaffected individuals, and significant results may be due to linkage but can also simply reflect population structure. To test for linkage after obtaining a significant case-control finding, within-family analysis can be performed. In a transmission/disequilibrium test (TDT), genotypes of cases are compared to those of their parents to explore whether a specific allele, or marker, at a locus of interest is transmitted to a greater degree than Mendelian inheritance would warrant. For multiallelic markers, several authors have proposed extensions to the TDT. In this article, we propose a TDT test, utilizing the available information of a case-control study in the grouping of alleles for multiallelic markers, and thereby increase the statistical power of a TDT test with a small sample size. © 2005 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/172416
ISSN
2015 Impact Factor: 4.58
2015 SCImago Journal Rankings: 2.077
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Wen_US
dc.contributor.authorFung, WKen_US
dc.date.accessioned2012-10-30T06:22:24Z-
dc.date.available2012-10-30T06:22:24Z-
dc.date.issued2005en_US
dc.identifier.citationEuropean Journal Of Human Genetics, 2005, v. 13 n. 9, p. 1007-1012en_US
dc.identifier.issn1018-4813en_US
dc.identifier.urihttp://hdl.handle.net/10722/172416-
dc.description.abstractCase-control studies compare marker-allele distributions in affected and unaffected individuals, and significant results may be due to linkage but can also simply reflect population structure. To test for linkage after obtaining a significant case-control finding, within-family analysis can be performed. In a transmission/disequilibrium test (TDT), genotypes of cases are compared to those of their parents to explore whether a specific allele, or marker, at a locus of interest is transmitted to a greater degree than Mendelian inheritance would warrant. For multiallelic markers, several authors have proposed extensions to the TDT. In this article, we propose a TDT test, utilizing the available information of a case-control study in the grouping of alleles for multiallelic markers, and thereby increase the statistical power of a TDT test with a small sample size. © 2005 Nature Publishing Group All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhgen_US
dc.relation.ispartofEuropean Journal of Human Geneticsen_US
dc.subjectCase-Controlen_US
dc.subjectLinkage Disequilibrium (Ld)en_US
dc.subjectMultiallelic Markeren_US
dc.subjectTransmission/Disequilibrium Test (Tdt)en_US
dc.titleCombining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markersen_US
dc.typeArticleen_US
dc.identifier.emailFung, WK: wingfung@hku.hken_US
dc.identifier.authorityFung, WK=rp00696en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.ejhg.5201453en_US
dc.identifier.pmid15957000-
dc.identifier.scopuseid_2-s2.0-27244461096en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27244461096&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue9en_US
dc.identifier.spage1007en_US
dc.identifier.epage1012en_US
dc.identifier.isiWOS:000231395500005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGuo, W=55259541500en_US
dc.identifier.scopusauthoridFung, WK=13310399400en_US
dc.identifier.citeulike228957-

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