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Article: Power of exclusion revisited: probability of excluding relatives of the true father from paternity

TitlePower of exclusion revisited: probability of excluding relatives of the true father from paternity
Authors
Issue Date2002
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00414/index.htm
Citation
International Journal of Legal Medicine, 2002, v. 116 n. 2, p. 64-67 How to Cite?
AbstractIn parentage testing using DNA markers, the formulae for calculating the probability of exclusion generally overstate the power of a test battery by considering its ability to exclude a random man. It is known that in many cases, in particular immigration applications, the false father is more likely to be a relative, e.g. brother, of the true father than an unrelated man. This work presents formulae that take this consideration into account. A practical example using Hong Kong data is provided to illustrate the effect of the modification. Also discussed is how the expected efficacy of a test battery will be affected when possible mutations and null alleles or genetic inconsistencies are taken into consideration.
Persistent Identifierhttp://hdl.handle.net/10722/172394
ISSN
2015 Impact Factor: 2.862
2015 SCImago Journal Rankings: 1.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFung, WKen_US
dc.contributor.authorChung, YKen_US
dc.contributor.authorWong, DMen_US
dc.date.accessioned2012-10-30T06:22:19Z-
dc.date.available2012-10-30T06:22:19Z-
dc.date.issued2002en_US
dc.identifier.citationInternational Journal of Legal Medicine, 2002, v. 116 n. 2, p. 64-67en_US
dc.identifier.issn0937-9827en_US
dc.identifier.urihttp://hdl.handle.net/10722/172394-
dc.description.abstractIn parentage testing using DNA markers, the formulae for calculating the probability of exclusion generally overstate the power of a test battery by considering its ability to exclude a random man. It is known that in many cases, in particular immigration applications, the false father is more likely to be a relative, e.g. brother, of the true father than an unrelated man. This work presents formulae that take this consideration into account. A practical example using Hong Kong data is provided to illustrate the effect of the modification. Also discussed is how the expected efficacy of a test battery will be affected when possible mutations and null alleles or genetic inconsistencies are taken into consideration.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00414/index.htmen_US
dc.relation.ispartofInternational Journal of Legal Medicineen_US
dc.subject.meshDna Fingerprinting - Methodsen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForensic Medicineen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPaternityen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshProbabilityen_US
dc.subject.meshTandem Repeat Sequencesen_US
dc.titlePower of exclusion revisited: probability of excluding relatives of the true father from paternityen_US
dc.typeArticleen_US
dc.identifier.emailFung, WK: wingfung@hku.hken_US
dc.identifier.authorityFung, WK=rp00696en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s004140100210en_US
dc.identifier.pmid12056522-
dc.identifier.scopuseid_2-s2.0-0036915431en_US
dc.identifier.hkuros69491-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036915431&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume116en_US
dc.identifier.issue2en_US
dc.identifier.spage64en_US
dc.identifier.epage67en_US
dc.identifier.isiWOS:000175617700002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridFung, WK=13310399400en_US
dc.identifier.scopusauthoridChung, YK=7404384597en_US
dc.identifier.scopusauthoridWong, DM=7401536015en_US

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