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Article: Moderating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adults

TitleModerating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adults
Authors
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/
Citation
American Journal Of Geriatric Psychiatry, 2010, v. 18 n. 4, p. 313-322 How to Cite?
AbstractOBJECTIVE: Depressive symptoms, which are both common and heritable, are important indicators of the extent of general well-being and health in old age. Identifying risk factors for depressive symptoms may lead to improved intervention and effective prevention. Both the presence of the apolipoprotein (APOE) genotype and loneliness are associated with later life symptoms of depression, and all three share a neuroendocrine signature, namely altered activity in the hypothalamic-pituitary-adrenal axis. The authors expected a positive association of loneliness with depressive symptoms, a negative link between APOE ε2 with depressive symptoms, and a significant genotype-environment interaction between loneliness (the social environment) and APOE ε2 on symptoms of depression. DESIGN: This was a cross-sectional observational study. SETTING AND PARTICIPANTS: A population-based sample of 979 Chinese people from Taiwan aged 54 years and older was examined. MEASUREMENTS: A short-form of the Center for Epidemiologic Studies of Depression Scale was used and the genotype of APOE was obtained. RESULTS: The interaction between loneliness and APOE ε2 was found to be negatively associated with depressive symptoms in adjusted regression models. Loneliness was also positively correlated with symptoms of depression. CONCLUSIONS: These data suggest that the APOE ε2 genotype decreases vulnerability to symptoms of depression in the presence of a social stressor, namely loneliness in this case, and has implications for the enhancement of well-being among older adults. Future studies are needed to delineate the mechanism underlying this gene-environment interaction. © 2010 American Association for Geriatric Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/172231
ISSN
2015 Impact Factor: 3.13
2015 SCImago Journal Rankings: 1.653
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChou, KLen_US
dc.date.accessioned2012-10-30T06:20:49Z-
dc.date.available2012-10-30T06:20:49Z-
dc.date.issued2010en_US
dc.identifier.citationAmerican Journal Of Geriatric Psychiatry, 2010, v. 18 n. 4, p. 313-322en_US
dc.identifier.issn1064-7481en_US
dc.identifier.urihttp://hdl.handle.net/10722/172231-
dc.description.abstractOBJECTIVE: Depressive symptoms, which are both common and heritable, are important indicators of the extent of general well-being and health in old age. Identifying risk factors for depressive symptoms may lead to improved intervention and effective prevention. Both the presence of the apolipoprotein (APOE) genotype and loneliness are associated with later life symptoms of depression, and all three share a neuroendocrine signature, namely altered activity in the hypothalamic-pituitary-adrenal axis. The authors expected a positive association of loneliness with depressive symptoms, a negative link between APOE ε2 with depressive symptoms, and a significant genotype-environment interaction between loneliness (the social environment) and APOE ε2 on symptoms of depression. DESIGN: This was a cross-sectional observational study. SETTING AND PARTICIPANTS: A population-based sample of 979 Chinese people from Taiwan aged 54 years and older was examined. MEASUREMENTS: A short-form of the Center for Epidemiologic Studies of Depression Scale was used and the genotype of APOE was obtained. RESULTS: The interaction between loneliness and APOE ε2 was found to be negatively associated with depressive symptoms in adjusted regression models. Loneliness was also positively correlated with symptoms of depression. CONCLUSIONS: These data suggest that the APOE ε2 genotype decreases vulnerability to symptoms of depression in the presence of a social stressor, namely loneliness in this case, and has implications for the enhancement of well-being among older adults. Future studies are needed to delineate the mechanism underlying this gene-environment interaction. © 2010 American Association for Geriatric Psychiatry.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/en_US
dc.relation.ispartofAmerican Journal of Geriatric Psychiatryen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshApolipoprotein E2 - Geneticsen_US
dc.subject.meshAsian Continental Ancestry Group - Genetics - Psychologyen_US
dc.subject.meshDepression - Genetics - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLoneliness - Psychologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.titleModerating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adultsen_US
dc.typeArticleen_US
dc.identifier.emailChou, KL: klchou@hku.hken_US
dc.identifier.authorityChou, KL=rp00583en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/JGP.0b013e3181c37b2aen_US
dc.identifier.pmid19910883-
dc.identifier.scopuseid_2-s2.0-77949498163en_US
dc.identifier.hkuros181446-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949498163&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.spage313en_US
dc.identifier.epage322en_US
dc.identifier.isiWOS:000276164700005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChou, KL=7201905320en_US

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