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Article: Moderating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adults
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TitleModerating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adults
 
AuthorsChou, KL1
 
Issue Date2010
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/
 
CitationAmerican Journal Of Geriatric Psychiatry, 2010, v. 18 n. 4, p. 313-322 [How to Cite?]
DOI: http://dx.doi.org/10.1097/JGP.0b013e3181c37b2a
 
AbstractOBJECTIVE: Depressive symptoms, which are both common and heritable, are important indicators of the extent of general well-being and health in old age. Identifying risk factors for depressive symptoms may lead to improved intervention and effective prevention. Both the presence of the apolipoprotein (APOE) genotype and loneliness are associated with later life symptoms of depression, and all three share a neuroendocrine signature, namely altered activity in the hypothalamic-pituitary-adrenal axis. The authors expected a positive association of loneliness with depressive symptoms, a negative link between APOE ε2 with depressive symptoms, and a significant genotype-environment interaction between loneliness (the social environment) and APOE ε2 on symptoms of depression. DESIGN: This was a cross-sectional observational study. SETTING AND PARTICIPANTS: A population-based sample of 979 Chinese people from Taiwan aged 54 years and older was examined. MEASUREMENTS: A short-form of the Center for Epidemiologic Studies of Depression Scale was used and the genotype of APOE was obtained. RESULTS: The interaction between loneliness and APOE ε2 was found to be negatively associated with depressive symptoms in adjusted regression models. Loneliness was also positively correlated with symptoms of depression. CONCLUSIONS: These data suggest that the APOE ε2 genotype decreases vulnerability to symptoms of depression in the presence of a social stressor, namely loneliness in this case, and has implications for the enhancement of well-being among older adults. Future studies are needed to delineate the mechanism underlying this gene-environment interaction. © 2010 American Association for Geriatric Psychiatry.
 
ISSN1064-7481
2012 Impact Factor: 4.131
2012 SCImago Journal Rankings: 1.877
 
DOIhttp://dx.doi.org/10.1097/JGP.0b013e3181c37b2a
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChou, KL
 
dc.date.accessioned2012-10-30T06:20:49Z
 
dc.date.available2012-10-30T06:20:49Z
 
dc.date.issued2010
 
dc.description.abstractOBJECTIVE: Depressive symptoms, which are both common and heritable, are important indicators of the extent of general well-being and health in old age. Identifying risk factors for depressive symptoms may lead to improved intervention and effective prevention. Both the presence of the apolipoprotein (APOE) genotype and loneliness are associated with later life symptoms of depression, and all three share a neuroendocrine signature, namely altered activity in the hypothalamic-pituitary-adrenal axis. The authors expected a positive association of loneliness with depressive symptoms, a negative link between APOE ε2 with depressive symptoms, and a significant genotype-environment interaction between loneliness (the social environment) and APOE ε2 on symptoms of depression. DESIGN: This was a cross-sectional observational study. SETTING AND PARTICIPANTS: A population-based sample of 979 Chinese people from Taiwan aged 54 years and older was examined. MEASUREMENTS: A short-form of the Center for Epidemiologic Studies of Depression Scale was used and the genotype of APOE was obtained. RESULTS: The interaction between loneliness and APOE ε2 was found to be negatively associated with depressive symptoms in adjusted regression models. Loneliness was also positively correlated with symptoms of depression. CONCLUSIONS: These data suggest that the APOE ε2 genotype decreases vulnerability to symptoms of depression in the presence of a social stressor, namely loneliness in this case, and has implications for the enhancement of well-being among older adults. Future studies are needed to delineate the mechanism underlying this gene-environment interaction. © 2010 American Association for Geriatric Psychiatry.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Geriatric Psychiatry, 2010, v. 18 n. 4, p. 313-322 [How to Cite?]
DOI: http://dx.doi.org/10.1097/JGP.0b013e3181c37b2a
 
dc.identifier.doihttp://dx.doi.org/10.1097/JGP.0b013e3181c37b2a
 
dc.identifier.epage322
 
dc.identifier.issn1064-7481
2012 Impact Factor: 4.131
2012 SCImago Journal Rankings: 1.877
 
dc.identifier.issue4
 
dc.identifier.pmid19910883
 
dc.identifier.scopuseid_2-s2.0-77949498163
 
dc.identifier.spage313
 
dc.identifier.urihttp://hdl.handle.net/10722/172231
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://ajgp.psychiatryonline.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Geriatric Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshApolipoprotein E2 - Genetics
 
dc.subject.meshAsian Continental Ancestry Group - Genetics - Psychology
 
dc.subject.meshDepression - Genetics - Psychology
 
dc.subject.meshFemale
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshLoneliness - Psychology
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshRisk Factors
 
dc.titleModerating effect of apolipoprotein genotype on loneliness leading to depressive symptoms in Chinese older adults
 
dc.typeArticle
 
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<description.abstract>OBJECTIVE: Depressive symptoms, which are both common and heritable, are important indicators of the extent of general well-being and health in old age. Identifying risk factors for depressive symptoms may lead to improved intervention and effective prevention. Both the presence of the apolipoprotein (APOE) genotype and loneliness are associated with later life symptoms of depression, and all three share a neuroendocrine signature, namely altered activity in the hypothalamic-pituitary-adrenal axis. The authors expected a positive association of loneliness with depressive symptoms, a negative link between APOE &#949;2 with depressive symptoms, and a significant genotype-environment interaction between loneliness (the social environment) and APOE &#949;2 on symptoms of depression. DESIGN: This was a cross-sectional observational study. SETTING AND PARTICIPANTS: A population-based sample of 979 Chinese people from Taiwan aged 54 years and older was examined. MEASUREMENTS: A short-form of the Center for Epidemiologic Studies of Depression Scale was used and the genotype of APOE was obtained. RESULTS: The interaction between loneliness and APOE &#949;2 was found to be negatively associated with depressive symptoms in adjusted regression models. Loneliness was also positively correlated with symptoms of depression. CONCLUSIONS: These data suggest that the APOE &#949;2 genotype decreases vulnerability to symptoms of depression in the presence of a social stressor, namely loneliness in this case, and has implications for the enhancement of well-being among older adults. Future studies are needed to delineate the mechanism underlying this gene-environment interaction. &#169; 2010 American Association for Geriatric Psychiatry.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong