File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritides

TitleTransforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritides
Authors
KeywordsCD4 T cells
Glomerulosclerosis
mRNA
Primary glomerulonephritides
Transforming growth factor-
Issue Date1996
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365599.asp
Citation
Scandinavian Journal Of Urology And Nephrology, 1996, v. 30 n. 3, p. 223-226 How to Cite?
AbstractImmunoreactivity to transforming growth factor-β (TGF-β) was detected in glomerular cells from patients with chronic glomerulonephritis, yet it remains uncertain whether the glomerular TGF-β deposits reflect TGF-β produced by the glomerular cells alone or from additional extrarenal origin. We examined the TGF-β messenger RNA (mRNA) expression in circulating CD4+ T cells from 45 patients with different primary glomerulonephritides. By semiquantitative polymerase chain reaction, the TGF-β mRNA expression was significantly raised in histopathologic entities characterized by increased mesangial proliferation or segmental sclerosis but not in histopathologic entities with little mesangial proliferation or sclerosis. These findings suggest that, other than TGF-β produced de novo, TGF-β from systemic source can also contribute to mesangial proliferation by binding to the glomerular cells after being filtered by the glomeruli. Increased TGF-β gene expression in CD4+ T cells in these patients may potentially enhance glomerular injury.
Persistent Identifierhttp://hdl.handle.net/10722/172014
ISSN
2014 Impact Factor: 1.243
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorHo, RTHen_HK
dc.contributor.authorLi, PKTen_HK
dc.date.accessioned2012-10-30T06:19:41Z-
dc.date.available2012-10-30T06:19:41Z-
dc.date.issued1996en_HK
dc.identifier.citationScandinavian Journal Of Urology And Nephrology, 1996, v. 30 n. 3, p. 223-226en_HK
dc.identifier.issn0036-5599en_HK
dc.identifier.urihttp://hdl.handle.net/10722/172014-
dc.description.abstractImmunoreactivity to transforming growth factor-β (TGF-β) was detected in glomerular cells from patients with chronic glomerulonephritis, yet it remains uncertain whether the glomerular TGF-β deposits reflect TGF-β produced by the glomerular cells alone or from additional extrarenal origin. We examined the TGF-β messenger RNA (mRNA) expression in circulating CD4+ T cells from 45 patients with different primary glomerulonephritides. By semiquantitative polymerase chain reaction, the TGF-β mRNA expression was significantly raised in histopathologic entities characterized by increased mesangial proliferation or segmental sclerosis but not in histopathologic entities with little mesangial proliferation or sclerosis. These findings suggest that, other than TGF-β produced de novo, TGF-β from systemic source can also contribute to mesangial proliferation by binding to the glomerular cells after being filtered by the glomeruli. Increased TGF-β gene expression in CD4+ T cells in these patients may potentially enhance glomerular injury.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365599.aspen_HK
dc.relation.ispartofScandinavian Journal of Urology and Nephrologyen_HK
dc.subjectCD4 T cellsen_HK
dc.subjectGlomerulosclerosisen_HK
dc.subjectmRNAen_HK
dc.subjectPrimary glomerulonephritidesen_HK
dc.subjectTransforming growth factor-en_HK
dc.subject.meshCd4-Positive T-Lymphocytes - Chemistryen_US
dc.subject.meshGlomerulonephritis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshRna, Messenger - Analysisen_US
dc.subject.meshTransforming Growth Factor Beta - Geneticsen_US
dc.titleTransforming growth factor-β mRNA expression in CD4+ T cells from patients with primary glomerulonephritidesen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailHo, RTH: tinho@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityHo, RTH=rp00497en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/00365599609181303-
dc.identifier.pmid8837255-
dc.identifier.scopuseid_2-s2.0-0029953904en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029953904&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage226en_HK
dc.identifier.isiWOS:A1996UX23100010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridHo, RTH=8620896500en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats