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Article: Common use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009

TitleCommon use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009
Authors
KeywordsAnticholinergic
Asia
Older Patients
Prescription Patterns
Schizophrenia
Issue Date2013
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/4294
Citation
International Journal Of Geriatric Psychiatry, 2013, v. 28 n. 3, p. 305-311 How to Cite?
AbstractObjective: This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates. Method: A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients' socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure. Results: The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications. Conclusions: Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. © 2012 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/171983
ISSN
2015 Impact Factor: 2.699
2015 SCImago Journal Rankings: 1.382
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_US
dc.contributor.authorDickerson, Fen_US
dc.contributor.authorKreyenbuhl, Jen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorSi, TMen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorChiu, HFen_US
dc.contributor.authorLai, KYCen_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorSim, Ken_US
dc.contributor.authorYong, MKHen_US
dc.contributor.authorTrivedi, JKen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorSartorius, Nen_US
dc.contributor.authorShinfuku, Nen_US
dc.date.accessioned2012-10-30T06:19:14Z-
dc.date.available2012-10-30T06:19:14Z-
dc.date.issued2013en_US
dc.identifier.citationInternational Journal Of Geriatric Psychiatry, 2013, v. 28 n. 3, p. 305-311en_US
dc.identifier.issn0885-6230en_US
dc.identifier.urihttp://hdl.handle.net/10722/171983-
dc.description.abstractObjective: This study surveyed the use of anticholinergic medications (ACMs) in older Asian patients with schizophrenia and examined its demographic and clinical correlates. Method: A total of 1452 hospitalized patients with schizophrenia aged 55 years or older in nine Asian countries and territories were surveyed between 2001 and 2009. The cross-sectional data of patients' socio-demographic and clinical characteristics and the prescriptions of antipsychotic drugs and ACM were recorded using a standardized protocol and data collection procedure. Results: The frequency of ACM prescription was 64.6% in the pooled sample, with 72.4%, 61.9%, and 59.5% in 2001, 2004, and 2009, respectively. Multiple logistic regression analysis of the whole sample revealed that patients on ACM had a higher dose of antipsychotic medications, and were more likely to have extrapyramidal side effects and receive first-generation antipsychotic medications. Conclusions: Anticholinergic medications were frequently used in older Asian patients with schizophrenia. Considering the potential side effects of ACM, the rationale for their widespread use in this patient population should be revisited. © 2012 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/4294en_US
dc.relation.ispartofInternational Journal of Geriatric Psychiatryen_US
dc.subjectAnticholinergicen_US
dc.subjectAsiaen_US
dc.subjectOlder Patientsen_US
dc.subjectPrescription Patternsen_US
dc.subjectSchizophreniaen_US
dc.titleCommon use of anticholinergic medications in older patients with schizophrenia: Findings of the Research on Asian Psychotropic Prescription Pattern (REAP) study, 2001-2009en_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/gps.3827en_US
dc.identifier.pmid22565547-
dc.identifier.scopuseid_2-s2.0-84873570470en_US
dc.identifier.hkuros224673-
dc.identifier.isiWOS:000314751800012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridDickerson, F=7003825018en_US
dc.identifier.scopusauthoridKreyenbuhl, J=6602795669en_US
dc.identifier.scopusauthoridUngvari, GS=36938621200en_US
dc.identifier.scopusauthoridWang, CY=35345843000en_US
dc.identifier.scopusauthoridSi, TM=6701400479en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridChiu, HF=55035304900en_US
dc.identifier.scopusauthoridLai, KYC=55194376000en_US
dc.identifier.scopusauthoridHe, YL=35313337300en_US
dc.identifier.scopusauthoridYang, SY=7406951183en_US
dc.identifier.scopusauthoridChong, MY=7102632108en_US
dc.identifier.scopusauthoridTan, CH=7402817882en_US
dc.identifier.scopusauthoridKua, EH=55195892100en_US
dc.identifier.scopusauthoridFujii, S=7401814463en_US
dc.identifier.scopusauthoridSim, K=55152349200en_US
dc.identifier.scopusauthoridYong, MKH=47161681100en_US
dc.identifier.scopusauthoridTrivedi, JK=7005836490en_US
dc.identifier.scopusauthoridChung, EK=7202734618en_US
dc.identifier.scopusauthoridUdomratn, P=6602459819en_US
dc.identifier.scopusauthoridChee, KY=36100061600en_US
dc.identifier.scopusauthoridSartorius, N=7102159482en_US
dc.identifier.scopusauthoridShinfuku, N=7003855366en_US

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