Article: Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia

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TitleCharacteristics and clinical correlates of prospective memory performance in first-episode schizophrenia
AuthorsZhou, FC6
Xiang, YT6 8
Wang, CY6
Dickerson, F7
Au, RWC8
Zhou, JJ6
Zhou, Y6
Shum, DHK4
Chiu, HFK8
Man, D3
Lee, EHM8
Yu, X5
Chan, RCK2
Ungvari, GS1
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
CitationSchizophrenia Research, 2012, v. 135 n. 1-3, p. 34-39 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2011.12.001
AbstractObjective: The aim of this study was to examine prospective memory (PM) and its socio-demographic, clinical, and neurocognitive correlates in first episode schizophrenia (FES). Methods: Fifty-one FES patients and 42 healthy controls formed the study sample. Time- and event-based PM (TBPM and EBPM) performance were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). A battery of neuropsychological tests was also administered. Patients' clinical symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS). Results: Patients performed significantly worse in both TBPM (8.7. ±. 5.3 vs. 14.8. ±. 3.5) and EBPM (11.3. ±. 4.7 vs. 15.7. ±. 2.7) than the controls. After controlling for age, gender, education level and neurocognitive test score, the difference in performance on the two types of PM tasks between patients and controls was no longer present. In multiple linear regression analyses, longer duration of untreated psychosis (DUP), lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the categories completed of the Wisconsin Card Sorting Test (WCST-CC) and higher score of the Color Trails Test-2 (CTT-2) contributed to poorer TBPM performance, while lower score of HVLT-R, higher score of the perseverative errors of the Wisconsin Card Sorting Test (WCST-PE) and longer DUP contributed to worse performance on EBPM. Conclusions: Both subtypes of PM are impaired in first-episode schizophrenia suggesting that PM deficits are an integral part of the cognitive dysfunction in the disease process. © 2011 Elsevier B.V.
ISSN0920-9964
2011 Impact Factor: 4.748
2011 SCImago Journal Rankings: 0.249
DOIhttp://dx.doi.org/10.1016/j.schres.2011.12.001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhou, FC
dc.contributor.authorXiang, YT
dc.contributor.authorWang, CY
dc.contributor.authorDickerson, F
dc.contributor.authorAu, RWC
dc.contributor.authorZhou, JJ
dc.contributor.authorZhou, Y
dc.contributor.authorShum, DHK
dc.contributor.authorChiu, HFK
dc.contributor.authorMan, D
dc.contributor.authorLee, EHM
dc.contributor.authorYu, X
dc.contributor.authorChan, RCK
dc.contributor.authorUngvari, GS
dc.date.accessioned2012-10-30T06:19:10Z
dc.date.available2012-10-30T06:19:10Z
dc.date.issued2012
dc.description.abstractObjective: The aim of this study was to examine prospective memory (PM) and its socio-demographic, clinical, and neurocognitive correlates in first episode schizophrenia (FES). Methods: Fifty-one FES patients and 42 healthy controls formed the study sample. Time- and event-based PM (TBPM and EBPM) performance were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). A battery of neuropsychological tests was also administered. Patients' clinical symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS). Results: Patients performed significantly worse in both TBPM (8.7. ±. 5.3 vs. 14.8. ±. 3.5) and EBPM (11.3. ±. 4.7 vs. 15.7. ±. 2.7) than the controls. After controlling for age, gender, education level and neurocognitive test score, the difference in performance on the two types of PM tasks between patients and controls was no longer present. In multiple linear regression analyses, longer duration of untreated psychosis (DUP), lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the categories completed of the Wisconsin Card Sorting Test (WCST-CC) and higher score of the Color Trails Test-2 (CTT-2) contributed to poorer TBPM performance, while lower score of HVLT-R, higher score of the perseverative errors of the Wisconsin Card Sorting Test (WCST-PE) and longer DUP contributed to worse performance on EBPM. Conclusions: Both subtypes of PM are impaired in first-episode schizophrenia suggesting that PM deficits are an integral part of the cognitive dysfunction in the disease process. © 2011 Elsevier B.V.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationSchizophrenia Research, 2012, v. 135 n. 1-3, p. 34-39 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.schres.2011.12.001
dc.identifier.citeulike10205139
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2011.12.001
dc.identifier.epage39
dc.identifier.hkuros206236
dc.identifier.issn0920-9964
2011 Impact Factor: 4.748
2011 SCImago Journal Rankings: 0.249
dc.identifier.issue1-3
dc.identifier.pmid22222379
dc.identifier.scopuseid_2-s2.0-84857236017
dc.identifier.spage34
dc.identifier.urihttp://hdl.handle.net/10722/171980
dc.identifier.volume135
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
dc.publisher.placeNetherlands
dc.relation.ispartofSchizophrenia Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshChi-Square Distribution
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMemory Disorders - Diagnosis - Etiology
dc.subject.meshMemory, Episodic
dc.subject.meshNeuropsychological Tests
dc.subject.meshPsychiatric Status Rating Scales
dc.subject.meshRegression Analysis
dc.subject.meshSchizophrenia - Complications
dc.subject.meshSchizophrenic Psychology
dc.subject.meshYoung Adult
dc.titleCharacteristics and clinical correlates of prospective memory performance in first-episode schizophrenia
dc.typeArticle
Author Affiliations
  1. University of Notre Dame Australia
  2. Chinese Academy of Sciences
  3. Hong Kong Polytechnic University
  4. Griffith University
  5. Peking University
  6. Capital Medical University China
  7. Stanley Research Program at Sheppard Pratt
  8. Chinese University of Hong Kong