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Article: Antipsychotic polypharmacy in inpatients with schizophrenia in Asia (2001-2009)

TitleAntipsychotic polypharmacy in inpatients with schizophrenia in Asia (2001-2009)
Authors
KeywordsAntipsychotic Polypharmacy
Prescription Patterns
Schizophrenia
Issue Date2012
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/pharmaco
Citation
Pharmacopsychiatry, 2012, v. 45 n. 1, p. 7-12 How to Cite?
AbstractObjective: This study aimed to identify trends in the use of antipsychotic polypharmacy (APP) and their demographic and clinical correlates in the treatment of schizophrenia in Asia between 2001 and 2009. Method: A total of 6761 schizophrenia inpatients in 9 Asian countries and territories were examined; 2399 in 2001, 2136 in 2004, and 2226 in 2009. Patients socio-demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The proportion of APP prescription decreased from 46.8% in 2001, to 38.3% in 2004, and increased to 43.4% in 2009, with wide inter-country variations at each survey. Multiple logistic regression analysis of the whole sample revealed that patients on APP were younger, had a higher dose of antipsychotics in chlorpromazine equivalents, and more severe positive and negative symptoms. They were also more likely to receive depot and first-generation antipsychotic drugs. Conclusions: The frequency of APP prescription varied between countries and territories, suggesting that a host of clinical and socio-cultural factors played a role in determining APP use in Asia. To resolve the discrepancy between treatment recommendation and clinical practice, regular reviews of prescription patterns are needed. © Georg Thieme Verlag KG Stuttgart - New York.
Persistent Identifierhttp://hdl.handle.net/10722/171976
ISSN
2015 Impact Factor: 1.474
2015 SCImago Journal Rankings: 0.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorSi, TMen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorSim, Ken_US
dc.contributor.authorYong, KHen_US
dc.contributor.authorTrivedi, JKen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorSartorius, Nen_US
dc.contributor.authorShinfuku, Nen_US
dc.date.accessioned2012-10-30T06:19:06Z-
dc.date.available2012-10-30T06:19:06Z-
dc.date.issued2012en_US
dc.identifier.citationPharmacopsychiatry, 2012, v. 45 n. 1, p. 7-12en_US
dc.identifier.issn0176-3679en_US
dc.identifier.urihttp://hdl.handle.net/10722/171976-
dc.description.abstractObjective: This study aimed to identify trends in the use of antipsychotic polypharmacy (APP) and their demographic and clinical correlates in the treatment of schizophrenia in Asia between 2001 and 2009. Method: A total of 6761 schizophrenia inpatients in 9 Asian countries and territories were examined; 2399 in 2001, 2136 in 2004, and 2226 in 2009. Patients socio-demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The proportion of APP prescription decreased from 46.8% in 2001, to 38.3% in 2004, and increased to 43.4% in 2009, with wide inter-country variations at each survey. Multiple logistic regression analysis of the whole sample revealed that patients on APP were younger, had a higher dose of antipsychotics in chlorpromazine equivalents, and more severe positive and negative symptoms. They were also more likely to receive depot and first-generation antipsychotic drugs. Conclusions: The frequency of APP prescription varied between countries and territories, suggesting that a host of clinical and socio-cultural factors played a role in determining APP use in Asia. To resolve the discrepancy between treatment recommendation and clinical practice, regular reviews of prescription patterns are needed. © Georg Thieme Verlag KG Stuttgart - New York.en_US
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/pharmacoen_US
dc.relation.ispartofPharmacopsychiatryen_US
dc.subjectAntipsychotic Polypharmacyen_US
dc.subjectPrescription Patternsen_US
dc.subjectSchizophreniaen_US
dc.titleAntipsychotic polypharmacy in inpatients with schizophrenia in Asia (2001-2009)en_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-0031-1286345en_US
dc.identifier.pmid21989602-
dc.identifier.scopuseid_2-s2.0-84855345384en_US
dc.identifier.hkuros206239-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855345384&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume45en_US
dc.identifier.issue1en_US
dc.identifier.spage7en_US
dc.identifier.epage12en_US
dc.identifier.isiWOS:000299909600002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridWang, CY=7501646810en_US
dc.identifier.scopusauthoridSi, TM=6701400479en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridHe, YL=24780698400en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridYang, SY=39561692200en_US
dc.identifier.scopusauthoridChong, MY=7102632108en_US
dc.identifier.scopusauthoridTan, CH=7402817882en_US
dc.identifier.scopusauthoridKua, EH=7006748699en_US
dc.identifier.scopusauthoridFujii, S=7401814463en_US
dc.identifier.scopusauthoridSim, K=8513485500en_US
dc.identifier.scopusauthoridYong, KH=37054832300en_US
dc.identifier.scopusauthoridTrivedi, JK=7005836490en_US
dc.identifier.scopusauthoridChung, EK=7202734618en_US
dc.identifier.scopusauthoridUdomratn, P=6602459819en_US
dc.identifier.scopusauthoridChee, KY=36100061600en_US
dc.identifier.scopusauthoridSartorius, N=7102159482en_US
dc.identifier.scopusauthoridShinfuku, N=7003855366en_US

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