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Article: Predictors of relapse in Chinese schizophrenia patients: A prospective, multi-center study

TitlePredictors of relapse in Chinese schizophrenia patients: A prospective, multi-center study
Authors
KeywordsChina
Maintenance Treatment
Paranoid
Relapse
Schizophrenia
Issue Date2011
PublisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/psychiatrie/journal/127
Citation
Social Psychiatry And Psychiatric Epidemiology, 2011, v. 46 n. 12, p. 1325-1330 How to Cite?
AbstractObjective: Relapse prevention is the main goal of maintenance treatment in schizophrenia. This study aimed to determine the rate and the socio-demographic and clinical predictors of relapse in Chinese schizophrenia patients following treatment of the acute phase of the illness. Methods: In a multi-center, randomized, controlled, longitudinal study, 404 patients with schizophrenia who were clinically stabilized following an acute episode were randomly assigned to either the maintenance (i.e., initial optimal therapeutic doses continued throughout the study) or the dose-reduction group (i.e., initial optimal therapeutic doses continued for 4 or 26 weeks followed by a 50% dose reduction that was maintained until the end of the study). Participants were interviewed at entry using standardized assessment instruments, and followed up for 12-26 months. Results: In univariate analyses, relapse was significantly associated with the membership of the dose-reduction group, poor medication adherence, and having a diagnosis of the paranoid type of schizophrenia. In Cox proportional-hazards regression analysis the membership of the dose-reduction group, poorer medication adherence, more severe drug-induced side effects and prominent paranoid symptoms independently predicted a higher risk of relapse. Conclusion: The study confirmed the importance of maintenance medication in preventing relapse in Chinese schizophrenia patients underscoring the risk of relapse associated with lack of treatment adherence, severe side effects and the patients' paranoid attitude. Socio-demographic characteristics were not associated with relapse in Chinese schizophrenia patients. Potential residual confounding caused by unmeasured variables should be fully considered in future studies. © 2010 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/171975
ISSN
2015 Impact Factor: 2.513
2015 SCImago Journal Rankings: 1.095
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorWeng, YZen_US
dc.contributor.authorBo, QJen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorChan, SSMen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorUngvari, GSen_US
dc.date.accessioned2012-10-30T06:19:05Z-
dc.date.available2012-10-30T06:19:05Z-
dc.date.issued2011en_US
dc.identifier.citationSocial Psychiatry And Psychiatric Epidemiology, 2011, v. 46 n. 12, p. 1325-1330en_US
dc.identifier.issn0933-7954en_US
dc.identifier.urihttp://hdl.handle.net/10722/171975-
dc.description.abstractObjective: Relapse prevention is the main goal of maintenance treatment in schizophrenia. This study aimed to determine the rate and the socio-demographic and clinical predictors of relapse in Chinese schizophrenia patients following treatment of the acute phase of the illness. Methods: In a multi-center, randomized, controlled, longitudinal study, 404 patients with schizophrenia who were clinically stabilized following an acute episode were randomly assigned to either the maintenance (i.e., initial optimal therapeutic doses continued throughout the study) or the dose-reduction group (i.e., initial optimal therapeutic doses continued for 4 or 26 weeks followed by a 50% dose reduction that was maintained until the end of the study). Participants were interviewed at entry using standardized assessment instruments, and followed up for 12-26 months. Results: In univariate analyses, relapse was significantly associated with the membership of the dose-reduction group, poor medication adherence, and having a diagnosis of the paranoid type of schizophrenia. In Cox proportional-hazards regression analysis the membership of the dose-reduction group, poorer medication adherence, more severe drug-induced side effects and prominent paranoid symptoms independently predicted a higher risk of relapse. Conclusion: The study confirmed the importance of maintenance medication in preventing relapse in Chinese schizophrenia patients underscoring the risk of relapse associated with lack of treatment adherence, severe side effects and the patients' paranoid attitude. Socio-demographic characteristics were not associated with relapse in Chinese schizophrenia patients. Potential residual confounding caused by unmeasured variables should be fully considered in future studies. © 2010 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/psychiatrie/journal/127en_US
dc.relation.ispartofSocial Psychiatry and Psychiatric Epidemiologyen_US
dc.subjectChinaen_US
dc.subjectMaintenance Treatmenten_US
dc.subjectParanoiden_US
dc.subjectRelapseen_US
dc.subjectSchizophreniaen_US
dc.titlePredictors of relapse in Chinese schizophrenia patients: A prospective, multi-center studyen_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00127-010-0304-1en_US
dc.identifier.pmid21046070-
dc.identifier.scopuseid_2-s2.0-83655182553en_US
dc.identifier.hkuros206355-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83655182553&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue12en_US
dc.identifier.spage1325en_US
dc.identifier.epage1330en_US
dc.identifier.isiWOS:000297154100014-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridWang, CY=47961486300en_US
dc.identifier.scopusauthoridWeng, YZ=7103320159en_US
dc.identifier.scopusauthoridBo, QJ=35799418800en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridChan, SSM=13409371900en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.citeulike8208521-

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