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Article: Use of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009

TitleUse of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009
Authors
Issue Date2011
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/pharmaco
Citation
Pharmacopsychiatry, 2011, v. 44 n. 3, p. 114-118 How to Cite?
AbstractObjective: The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates. Method: A total of 6761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones. Conclusions: The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice. © Georg Thieme Verlag KG Stuttgart - New York.
Persistent Identifierhttp://hdl.handle.net/10722/171962
ISSN
2015 Impact Factor: 1.474
2015 SCImago Journal Rankings: 0.654
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorSi, TMen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorSim, Ken_US
dc.contributor.authorYong, KHen_US
dc.contributor.authorTrivedi, JKen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorSartorius, Nen_US
dc.contributor.authorShinfuku, Nen_US
dc.date.accessioned2012-10-30T06:18:53Z-
dc.date.available2012-10-30T06:18:53Z-
dc.date.issued2011en_US
dc.identifier.citationPharmacopsychiatry, 2011, v. 44 n. 3, p. 114-118en_US
dc.identifier.issn0176-3679en_US
dc.identifier.urihttp://hdl.handle.net/10722/171962-
dc.description.abstractObjective: The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates. Method: A total of 6761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones. Conclusions: The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice. © Georg Thieme Verlag KG Stuttgart - New York.en_US
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/pharmacoen_US
dc.relation.ispartofPharmacopsychiatryen_US
dc.subject.meshAntipsychotic Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshAsiaen_US
dc.subject.meshCholinergic Antagonists - Adverse Effects - Therapeutic Useen_US
dc.subject.meshDrug Prescriptions - Statistics & Numerical Dataen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEpidemiologic Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMovement Disorders - Physiopathologyen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshSchizophrenia - Diagnosis - Drug Therapy - Pathology - Physiopathologyen_US
dc.titleUse of anticholinergic drugs in patients with schizophrenia in Asia from 2001 to 2009en_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-0031-1275658en_US
dc.identifier.pmid21491361-
dc.identifier.scopuseid_2-s2.0-79956116039en_US
dc.identifier.hkuros224708-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956116039&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue3en_US
dc.identifier.spage114en_US
dc.identifier.epage118en_US
dc.identifier.isiWOS:000291367000005-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridWang, CY=7501646810en_US
dc.identifier.scopusauthoridSi, TM=6701400479en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridHe, YL=24780698400en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridYang, SY=39561692200en_US
dc.identifier.scopusauthoridChong, MY=7102632108en_US
dc.identifier.scopusauthoridTan, CH=7402817882en_US
dc.identifier.scopusauthoridKua, EH=7006748699en_US
dc.identifier.scopusauthoridFujii, S=7401814463en_US
dc.identifier.scopusauthoridSim, K=8513485500en_US
dc.identifier.scopusauthoridYong, KH=37054832300en_US
dc.identifier.scopusauthoridTrivedi, JK=7005836490en_US
dc.identifier.scopusauthoridChung, EK=7202734618en_US
dc.identifier.scopusauthoridUdomratn, P=6602459819en_US
dc.identifier.scopusauthoridChee, KY=36100061600en_US
dc.identifier.scopusauthoridSartorius, N=7102159482en_US
dc.identifier.scopusauthoridShinfuku, N=7003855366en_US

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