File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies

TitleSex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studies
Authors
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anp
Citation
Australian And New Zealand Journal Of Psychiatry, 2011, v. 45 n. 3, p. 193-198 How to Cite?
AbstractObjective: The aim of this study was to investigate the sex differences in prescribing patterns of psychotropic drugs and drug-induced side effects in schizophrenia patients in Asia using the data of the Research on Asian Psychotropic Prescription Pattern (REAP) surveys. Method: The prescription patterns of 6,441 schizophrenia inpatients in six Asian countries and regions were investigated during the 2001-2009 period. The patients' socio-demographic and clinical characteristics and their prescriptions for psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: Univariate analyses found the following factors to be significantly associated with the male sex: a younger age, higher doses of antipsychotics, less prominent delusions and hallucinations, more prominent negative symptoms, less likelihood of a prescription for second-generation antipsychotics (SGAs), greater use of antipsychotic polypharmacy, mood stabilizers and depot antipsychotics, more frequent tardive dyskinesia (TD), and less weight gain. In multivariate analyses, fewer prescriptions for SGAs, greater use of mood stabilizers, anticholinergics, antipsychotic polypharmacy and depot antipsychotics, extrapyramidal side effects (EPS) and TD, and less weight gain were independently associated with the male sex. Conclusions: Sex is one of the independent contributors to psychotropic prescription and side effects in Asian schizophrenia patients. Psychopharmacological treatment guidelines for schizophrenia should consider the sexes separately. © 2011 The Royal Australian and New Zealand College of Psychiatrists.
Persistent Identifierhttp://hdl.handle.net/10722/171961
ISSN
2015 Impact Factor: 3.536
2015 SCImago Journal Rankings: 1.269
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorSi, TMen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorShinfuku, Nen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorSim, Ken_US
dc.contributor.authorYong, KHen_US
dc.contributor.authorTrivedi, JKen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorSartorius, Nen_US
dc.date.accessioned2012-10-30T06:18:52Z-
dc.date.available2012-10-30T06:18:52Z-
dc.date.issued2011en_US
dc.identifier.citationAustralian And New Zealand Journal Of Psychiatry, 2011, v. 45 n. 3, p. 193-198en_US
dc.identifier.issn0004-8674en_US
dc.identifier.urihttp://hdl.handle.net/10722/171961-
dc.description.abstractObjective: The aim of this study was to investigate the sex differences in prescribing patterns of psychotropic drugs and drug-induced side effects in schizophrenia patients in Asia using the data of the Research on Asian Psychotropic Prescription Pattern (REAP) surveys. Method: The prescription patterns of 6,441 schizophrenia inpatients in six Asian countries and regions were investigated during the 2001-2009 period. The patients' socio-demographic and clinical characteristics and their prescriptions for psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: Univariate analyses found the following factors to be significantly associated with the male sex: a younger age, higher doses of antipsychotics, less prominent delusions and hallucinations, more prominent negative symptoms, less likelihood of a prescription for second-generation antipsychotics (SGAs), greater use of antipsychotic polypharmacy, mood stabilizers and depot antipsychotics, more frequent tardive dyskinesia (TD), and less weight gain. In multivariate analyses, fewer prescriptions for SGAs, greater use of mood stabilizers, anticholinergics, antipsychotic polypharmacy and depot antipsychotics, extrapyramidal side effects (EPS) and TD, and less weight gain were independently associated with the male sex. Conclusions: Sex is one of the independent contributors to psychotropic prescription and side effects in Asian schizophrenia patients. Psychopharmacological treatment guidelines for schizophrenia should consider the sexes separately. © 2011 The Royal Australian and New Zealand College of Psychiatrists.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/anpen_US
dc.relation.ispartofAustralian and New Zealand Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAntipsychotic Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshAsiaen_US
dc.subject.meshDrug Utilization - Statistics & Numerical Dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSchizophrenia - Drug Therapyen_US
dc.subject.meshSex Characteristicsen_US
dc.titleSex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: Findings of the Research on Asia Psychotropic Prescription (REAP) studiesen_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/00048674.2010.538839en_US
dc.identifier.pmid21142850-
dc.identifier.scopuseid_2-s2.0-79952291403en_US
dc.identifier.hkuros224710-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952291403&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume45en_US
dc.identifier.issue3en_US
dc.identifier.spage193en_US
dc.identifier.epage198en_US
dc.identifier.isiWOS:000287742800003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridWang, CY=47961486300en_US
dc.identifier.scopusauthoridSi, TM=6701400479en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridHe, YL=35313337300en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.scopusauthoridChiu, HFK=24447976700en_US
dc.identifier.scopusauthoridYang, SY=25958514300en_US
dc.identifier.scopusauthoridChong, MY=7102632108en_US
dc.identifier.scopusauthoridShinfuku, N=7003855366en_US
dc.identifier.scopusauthoridTan, CH=7402817882en_US
dc.identifier.scopusauthoridKua, EH=7006748699en_US
dc.identifier.scopusauthoridFujii, S=7401814463en_US
dc.identifier.scopusauthoridSim, K=8513485500en_US
dc.identifier.scopusauthoridYong, KH=37054832300en_US
dc.identifier.scopusauthoridTrivedi, JK=7005836490en_US
dc.identifier.scopusauthoridChung, EK=7202734618en_US
dc.identifier.scopusauthoridUdomratn, P=6602459819en_US
dc.identifier.scopusauthoridChee, KY=36100061600en_US
dc.identifier.scopusauthoridSartorius, N=7102159482en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats