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Article: Neurological abnormalities in Chinese schizophrenic patients

TitleNeurological abnormalities in Chinese schizophrenic patients
Authors
Issue Date2007
PublisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/09534180.php
Citation
Behavioural Neurology, 2007, v. 18 n. 3, p. 171-181 How to Cite?
AbstractBackground: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia. Methods: A cross-sectional design was adopted with the use of the Cambridge Neurological Inventory (CNI). The CNI is comprised of 7 subscales, including motor coordination, sensory integration, disinhibition, extrapyramidal signs, dyskinesia, catatonia, and pyramidal signs. The former 3 subscales were classified as soft signs, whereas the latter 4 subscales were classified as hard signs. A total of 250 Chinese schizophrenic patients and 90 normal controls were recruited. Results: Patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs (p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs (p < 0.0005). The three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the four subscales of hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0.63 and specificity of 0.71; whereas a cut-off of 1 in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A global cut-off of 5 in total neurological signs results in a sensitivity of 0.81 and specificity of 0.73 for detecting schizophrenia versus normal. Conclusions: High levels of neurological abnormality characterize schizophrenic patients. An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more strongly associated with schizophrenia than are hard signs in the Chinese sample. © 2007 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171942
ISSN
2015 Impact Factor: 1.629
2015 SCImago Journal Rankings: 0.696
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, RCKen_US
dc.contributor.authorChen, EYHen_US
dc.date.accessioned2012-10-30T06:18:40Z-
dc.date.available2012-10-30T06:18:40Z-
dc.date.issued2007en_US
dc.identifier.citationBehavioural Neurology, 2007, v. 18 n. 3, p. 171-181en_US
dc.identifier.issn0953-4180en_US
dc.identifier.urihttp://hdl.handle.net/10722/171942-
dc.description.abstractBackground: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia. Methods: A cross-sectional design was adopted with the use of the Cambridge Neurological Inventory (CNI). The CNI is comprised of 7 subscales, including motor coordination, sensory integration, disinhibition, extrapyramidal signs, dyskinesia, catatonia, and pyramidal signs. The former 3 subscales were classified as soft signs, whereas the latter 4 subscales were classified as hard signs. A total of 250 Chinese schizophrenic patients and 90 normal controls were recruited. Results: Patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs (p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs (p < 0.0005). The three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the four subscales of hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0.63 and specificity of 0.71; whereas a cut-off of 1 in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A global cut-off of 5 in total neurological signs results in a sensitivity of 0.81 and specificity of 0.73 for detecting schizophrenia versus normal. Conclusions: High levels of neurological abnormality characterize schizophrenic patients. An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more strongly associated with schizophrenia than are hard signs in the Chinese sample. © 2007 - IOS Press and the authors. All rights reserved.en_US
dc.languageengen_US
dc.publisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/09534180.phpen_US
dc.relation.ispartofBehavioural Neurologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Statistics & Numerical Dataen_US
dc.subject.meshBasal Ganglia Diseases - Diagnosis - Epidemiology - Physiopathologyen_US
dc.subject.meshBrain - Physiopathologyen_US
dc.subject.meshCatatonia - Diagnosis - Epidemiology - Physiopathologyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDyskinesias - Diagnosis - Epidemiology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurologic Examinationen_US
dc.subject.meshObserver Variationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPsychomotor Performance - Physiologyen_US
dc.subject.meshRoc Curveen_US
dc.subject.meshSchizophrenia - Epidemiology - Physiopathologyen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.titleNeurological abnormalities in Chinese schizophrenic patientsen_US
dc.typeArticleen_US
dc.identifier.emailChen, EYH:eyhchen@hku.hken_US
dc.identifier.authorityChen, EYH=rp00392en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2007/451703-
dc.identifier.pmid17726246-
dc.identifier.scopuseid_2-s2.0-34548073604en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548073604&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.spage171en_US
dc.identifier.epage181en_US
dc.identifier.isiWOS:000249670900006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridChan, RCK=35236280300en_US
dc.identifier.scopusauthoridChen, EYH=7402315729en_US

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