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Article: No evidence of association between a polymorphism in the COMT gene and clinical phenotypes of schizophrenia in China

TitleNo evidence of association between a polymorphism in the COMT gene and clinical phenotypes of schizophrenia in China
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 527 How to Cite?
AbstractCatechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, has been implicated in the pathogenesis of schizophrenia. Genetic polymorphism with a valine to methionine substitution at amino acid 158 leading to low-activity variant of the enzyme has been found to be associated with schizophrenia and violent behavior. However, negative findings have also been reported. We conducted a case-control study of the val158met polymorphism of the COMT gene to investigate the possible association with schizophrenia and clinical phenotypes in Chinese. Two hundred and six unrelated schizophrenic patients and 286 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotype and allele frequencies of COMT polymorphisms by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes including frontal lobe function, clinical symptoms, treatment response, suicide and violent behavior. Our data suggest that val158met polymorphism of COMT gene is not associated with schizophrenia at least at the diagnostic level. In view of our modest sample size and the low frequency of homozygous met158 genotype in the Chinese population, further large scale studies with detailed characterization of endophenotypes are essential for mapping this gene to schizophrenia and the associated traits.
Persistent Identifierhttp://hdl.handle.net/10722/171938
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorChen, RYLen_US
dc.contributor.authorShum, PCen_US
dc.contributor.authorChen, EYHen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorCheung, EFCen_US
dc.contributor.authorHui, TCKen_US
dc.contributor.authorKwok, CLen_US
dc.contributor.authorLieh Mak, Fen_US
dc.contributor.authorZhao, JHen_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-10-30T06:18:37Z-
dc.date.available2012-10-30T06:18:37Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 527en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/171938-
dc.description.abstractCatechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, has been implicated in the pathogenesis of schizophrenia. Genetic polymorphism with a valine to methionine substitution at amino acid 158 leading to low-activity variant of the enzyme has been found to be associated with schizophrenia and violent behavior. However, negative findings have also been reported. We conducted a case-control study of the val158met polymorphism of the COMT gene to investigate the possible association with schizophrenia and clinical phenotypes in Chinese. Two hundred and six unrelated schizophrenic patients and 286 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotype and allele frequencies of COMT polymorphisms by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes including frontal lobe function, clinical symptoms, treatment response, suicide and violent behavior. Our data suggest that val158met polymorphism of COMT gene is not associated with schizophrenia at least at the diagnostic level. In view of our modest sample size and the low frequency of homozygous met158 genotype in the Chinese population, further large scale studies with detailed characterization of endophenotypes are essential for mapping this gene to schizophrenia and the associated traits.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleNo evidence of association between a polymorphism in the COMT gene and clinical phenotypes of schizophrenia in Chinaen_US
dc.typeArticleen_US
dc.identifier.emailChen, EYH:eyhchen@hku.hken_US
dc.identifier.authorityChen, EYH=rp00392en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749099056en_US
dc.identifier.volume96en_US
dc.identifier.issue4en_US
dc.identifier.spage527en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, RYL=16635066600en_US
dc.identifier.scopusauthoridShum, PC=14634895200en_US
dc.identifier.scopusauthoridChen, EYH=7402315729en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridCheung, EFC=7006522469en_US
dc.identifier.scopusauthoridHui, TCK=7005618911en_US
dc.identifier.scopusauthoridKwok, CL=35989055900en_US
dc.identifier.scopusauthoridLieh Mak, F=6603893598en_US
dc.identifier.scopusauthoridZhao, JH=7410311266en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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