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Article: Alteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans rats

TitleAlteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans rats
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2000, v. 100 n. 4, p. 769-775 How to Cite?
AbstractNeuronal nitric oxide synthase and haem oxygenase-2 are postulated to be important enzymes involved in neuronal transmission and modulation of free radical levels in neurons. Hippocampal and cortical neuronal nitric oxide synthase and haem oxygenase-2 expressions were compared in young adult (6 months) and aged (24-26 months) Long-Evans rats. Aged rats were assigned as either cognitively unimpaired or impaired based on their performances in the Morris water maze behavioural task. In situ hybridization revealed increased neuronal nitric oxide synthase messenger RNA levels in selected regions of the hippocampi and cortices of aged rats. Moreover, aged cognitively impaired animals showed significantly higher neuronal nitric oxide synthase messenger RNA expression than aged cognitively unimpaired animals in several brain regions. For haem oxygenase-2 mRNA expressions, both young and aged cognitively impaired rats showed increased expressions in hippocampi compared with aged cognitively unimpaired rats, while no difference was found in cortices between all three animal groups. The increase in neuronal nitric oxide synthase messenger RNA expression levels in the aged animals may be related to increased free radical production occurring in ageing. Alternatively, elevated neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA expressions may represent compensatory responses to oxidative stress and age-related changes in neuronal functions. Regarding cognitive status, aged cognitively impaired rats showed significant spatial memory deficits relative to young and aged cognitively unimpaired rats.Our data suggest a correlation between age-related cognitive impairment and change in messenger RNA expressions for the neuronal nitric oxide synthase and haem oxygenase-2 systems in brain areas implicated in learning and memory processes. Copyright (C) 2000 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/171901
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorLaw, Aen_US
dc.contributor.authorDoré, Sen_US
dc.contributor.authorBlackshaw, Sen_US
dc.contributor.authorGauthier, Sen_US
dc.contributor.authorQuirion, Ren_US
dc.date.accessioned2012-10-30T06:18:19Z-
dc.date.available2012-10-30T06:18:19Z-
dc.date.issued2000en_US
dc.identifier.citationNeuroscience, 2000, v. 100 n. 4, p. 769-775en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/171901-
dc.description.abstractNeuronal nitric oxide synthase and haem oxygenase-2 are postulated to be important enzymes involved in neuronal transmission and modulation of free radical levels in neurons. Hippocampal and cortical neuronal nitric oxide synthase and haem oxygenase-2 expressions were compared in young adult (6 months) and aged (24-26 months) Long-Evans rats. Aged rats were assigned as either cognitively unimpaired or impaired based on their performances in the Morris water maze behavioural task. In situ hybridization revealed increased neuronal nitric oxide synthase messenger RNA levels in selected regions of the hippocampi and cortices of aged rats. Moreover, aged cognitively impaired animals showed significantly higher neuronal nitric oxide synthase messenger RNA expression than aged cognitively unimpaired animals in several brain regions. For haem oxygenase-2 mRNA expressions, both young and aged cognitively impaired rats showed increased expressions in hippocampi compared with aged cognitively unimpaired rats, while no difference was found in cortices between all three animal groups. The increase in neuronal nitric oxide synthase messenger RNA expression levels in the aged animals may be related to increased free radical production occurring in ageing. Alternatively, elevated neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA expressions may represent compensatory responses to oxidative stress and age-related changes in neuronal functions. Regarding cognitive status, aged cognitively impaired rats showed significant spatial memory deficits relative to young and aged cognitively unimpaired rats.Our data suggest a correlation between age-related cognitive impairment and change in messenger RNA expressions for the neuronal nitric oxide synthase and haem oxygenase-2 systems in brain areas implicated in learning and memory processes. Copyright (C) 2000 IBRO.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshCerebral Cortex - Metabolismen_US
dc.subject.meshCognition Disorders - Metabolism - Psychologyen_US
dc.subject.meshHeme Oxygenase (Decyclizing) - Metabolismen_US
dc.subject.meshHippocampus - Metabolismen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshNitric Oxide Synthase - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Long-Evansen_US
dc.titleAlteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans ratsen_US
dc.typeArticleen_US
dc.identifier.emailLaw, A:acklaw@hku.hken_US
dc.identifier.authorityLaw, A=rp00262en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0306-4522(00)00316-Xen_US
dc.identifier.pmid11036210-
dc.identifier.scopuseid_2-s2.0-0034638487en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034638487&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100en_US
dc.identifier.issue4en_US
dc.identifier.spage769en_US
dc.identifier.epage775en_US
dc.identifier.isiWOS:000165222200011-
dc.publisher.placeNetherlandsen_US
dc.relation.erratumdoi:10.1016/S0306-4522(01)00126-9-
dc.relation.erratumeid:eid_2-s2.0-0035836494-
dc.identifier.scopusauthoridLaw, A=26323772800en_US
dc.identifier.scopusauthoridDoré, S=7005287709en_US
dc.identifier.scopusauthoridBlackshaw, S=7005955229en_US
dc.identifier.scopusauthoridGauthier, S=7102604782en_US
dc.identifier.scopusauthoridQuirion, R=7202416940en_US

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