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Article: A functional neuroanatomy of hallucinations in schizophrenia

TitleA functional neuroanatomy of hallucinations in schizophrenia
Authors
Issue Date1995
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1995, v. 378 n. 6553, p. 176-179 How to Cite?
AbstractHALLUCINATIONS, perceptions in the absence of external stimuli, are prominent among the core symptoms of schizophrenia. The neural correlates of these brief, involuntary experiences are not well understood, and have not been imaged selectively. We have used new positron emission tomography (PET) methods to study the brain state associated with the occurrence of hallucinations in six schizophrenic patients. Here we present a group study of five patients with classic auditory verbal hallucinations despite medication, demonstrating activations in subcortical nuclei (thalamic, striatal), limbic structures (especially hippocampus), and paralimbic regions (parahippocampal and cingulate gyri, as well as orbito-frontal cortex). We also present a case study of a unique, drug-naive patient with visual as well as auditory verbal hallucinations, demonstrating activations in visual and auditory/linguistic association cortices as part of a distributed cortical-subcortical network. Activity in deep brain structures, identified with group analysis, may generate or modulate hallucinations, and the particular neocortical regions entrained in individual patients may affect their specific perceptual content. The interaction of these distributed neural systems provides a biological basis for the bizarre reports of schizophrenic patients.
Persistent Identifierhttp://hdl.handle.net/10722/171884
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSilbersweig, DAen_US
dc.contributor.authorStern, Een_US
dc.contributor.authorFrith, Cen_US
dc.contributor.authorCahill, Cen_US
dc.contributor.authorHolmes, Aen_US
dc.contributor.authorGrootoonk, Sen_US
dc.contributor.authorSeaward, Jen_US
dc.contributor.authorMckenna, Pen_US
dc.contributor.authorChua, SEen_US
dc.contributor.authorSchnorr, Len_US
dc.contributor.authorJones, Ten_US
dc.contributor.authorFrackowiak, RSJen_US
dc.date.accessioned2012-10-30T06:18:10Z-
dc.date.available2012-10-30T06:18:10Z-
dc.date.issued1995en_US
dc.identifier.citationNature, 1995, v. 378 n. 6553, p. 176-179en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://hdl.handle.net/10722/171884-
dc.description.abstractHALLUCINATIONS, perceptions in the absence of external stimuli, are prominent among the core symptoms of schizophrenia. The neural correlates of these brief, involuntary experiences are not well understood, and have not been imaged selectively. We have used new positron emission tomography (PET) methods to study the brain state associated with the occurrence of hallucinations in six schizophrenic patients. Here we present a group study of five patients with classic auditory verbal hallucinations despite medication, demonstrating activations in subcortical nuclei (thalamic, striatal), limbic structures (especially hippocampus), and paralimbic regions (parahippocampal and cingulate gyri, as well as orbito-frontal cortex). We also present a case study of a unique, drug-naive patient with visual as well as auditory verbal hallucinations, demonstrating activations in visual and auditory/linguistic association cortices as part of a distributed cortical-subcortical network. Activity in deep brain structures, identified with group analysis, may generate or modulate hallucinations, and the particular neocortical regions entrained in individual patients may affect their specific perceptual content. The interaction of these distributed neural systems provides a biological basis for the bizarre reports of schizophrenic patients.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_US
dc.relation.ispartofNatureen_US
dc.subject.meshAdulten_US
dc.subject.meshBrain - Blood Supply - Physiopathologyen_US
dc.subject.meshCerebrovascular Circulationen_US
dc.subject.meshHallucinations - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSchizophrenia - Drug Therapy - Physiopathologyen_US
dc.subject.meshTomography, Emission-Computeden_US
dc.titleA functional neuroanatomy of hallucinations in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailChua, SE:sechua@hku.hken_US
dc.identifier.authorityChua, SE=rp00438en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/378176a0-
dc.identifier.pmid7477318-
dc.identifier.scopuseid_2-s2.0-0028847356en_US
dc.identifier.volume378en_US
dc.identifier.issue6553en_US
dc.identifier.spage176en_US
dc.identifier.epage179en_US
dc.identifier.isiWOS:A1995TD75900051-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSilbersweig, DA=7003349900en_US
dc.identifier.scopusauthoridStern, E=7202429809en_US
dc.identifier.scopusauthoridFrith, C=36051252900en_US
dc.identifier.scopusauthoridCahill, C=7103290039en_US
dc.identifier.scopusauthoridHolmes, A=25927091400en_US
dc.identifier.scopusauthoridGrootoonk, S=6601998905en_US
dc.identifier.scopusauthoridSeaward, J=6507337708en_US
dc.identifier.scopusauthoridMckenna, P=7201921663en_US
dc.identifier.scopusauthoridChua, SE=7201550427en_US
dc.identifier.scopusauthoridSchnorr, L=6602363908en_US
dc.identifier.scopusauthoridJones, T=35401529100en_US
dc.identifier.scopusauthoridFrackowiak, RSJ=35400736400en_US

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