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- Publisher Website: 10.3390/molecules17044343
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- PMID: 22491682
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Article: Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications
Title | Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications |
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Authors | |
Keywords | cADPR analogue Calcium mobilization Nucleotide Synthesis |
Issue Date | 2012 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules |
Citation | Molecules, 2012, v. 17 n. 4, p. 4343-4356 How to Cite? |
Abstract | Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2'-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3'-OH of the southern riboses does not obviously alter the agonistic activity. © 2012 by the authors. |
Persistent Identifier | http://hdl.handle.net/10722/171790 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 0.744 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhou, Y | en_US |
dc.contributor.author | Yu, P | en_US |
dc.contributor.author | Jin, H | en_US |
dc.contributor.author | Yang, Z | en_US |
dc.contributor.author | Yue, J | en_US |
dc.contributor.author | Zhang, L | en_US |
dc.contributor.author | Zhang, L | en_US |
dc.date.accessioned | 2012-10-30T06:17:08Z | - |
dc.date.available | 2012-10-30T06:17:08Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Molecules, 2012, v. 17 n. 4, p. 4343-4356 | en_US |
dc.identifier.issn | 1420-3049 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171790 | - |
dc.description.abstract | Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2'-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3'-OH of the southern riboses does not obviously alter the agonistic activity. © 2012 by the authors. | en_US |
dc.language | eng | en_US |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules | en_US |
dc.relation.ispartof | Molecules | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | cADPR analogue | - |
dc.subject | Calcium mobilization | - |
dc.subject | Nucleotide | - |
dc.subject | Synthesis | - |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Calcium Signaling - Drug Effects | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Cyclic Adp-Ribose - Analogs & Derivatives - Chemical Synthesis - Chemistry - Pharmacology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydrophobic And Hydrophilic Interactions | en_US |
dc.subject.mesh | Models, Molecular | en_US |
dc.title | Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yue, J:jyue@hku.hk | en_US |
dc.identifier.authority | Yue, J=rp00286 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.3390/molecules17044343 | en_US |
dc.identifier.pmid | 22491682 | - |
dc.identifier.scopus | eid_2-s2.0-84860257725 | en_US |
dc.identifier.hkuros | 208768 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84860257725&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 4343 | en_US |
dc.identifier.epage | 4356 | en_US |
dc.identifier.isi | WOS:000303309900051 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Zhou, Y=55199306000 | en_US |
dc.identifier.scopusauthorid | Yu, P=55034912300 | en_US |
dc.identifier.scopusauthorid | Jin, H=36561657200 | en_US |
dc.identifier.scopusauthorid | Yang, Z=7405435277 | en_US |
dc.identifier.scopusauthorid | Yue, J=7101875828 | en_US |
dc.identifier.scopusauthorid | Zhang, L=8833065300 | en_US |
dc.identifier.scopusauthorid | Zhang, L=15040200600 | en_US |
dc.identifier.issnl | 1420-3049 | - |