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Article: Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications

TitleSynthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications
Authors
Issue Date2012
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/molecules
Citation
Molecules, 2012, v. 17 n. 4, p. 4343-4356 How to Cite?
AbstractNovel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2'-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3'-OH of the southern riboses does not obviously alter the agonistic activity. © 2012 by the authors.
Persistent Identifierhttp://hdl.handle.net/10722/171790
ISSN
2015 Impact Factor: 2.465
2015 SCImago Journal Rankings: 0.544
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Yen_US
dc.contributor.authorYu, Pen_US
dc.contributor.authorJin, Hen_US
dc.contributor.authorYang, Zen_US
dc.contributor.authorYue, Jen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorZhang, Len_US
dc.date.accessioned2012-10-30T06:17:08Z-
dc.date.available2012-10-30T06:17:08Z-
dc.date.issued2012en_US
dc.identifier.citationMolecules, 2012, v. 17 n. 4, p. 4343-4356en_US
dc.identifier.issn1420-3049en_US
dc.identifier.urihttp://hdl.handle.net/10722/171790-
dc.description.abstractNovel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2'-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3'-OH of the southern riboses does not obviously alter the agonistic activity. © 2012 by the authors.en_US
dc.languageengen_US
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/moleculesen_US
dc.relation.ispartofMoleculesen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCalcium Signaling - Drug Effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCyclic Adp-Ribose - Analogs & Derivatives - Chemical Synthesis - Chemistry - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrophobic And Hydrophilic Interactionsen_US
dc.subject.meshModels, Molecularen_US
dc.titleSynthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modificationsen_US
dc.typeArticleen_US
dc.identifier.emailYue, J:jyue@hku.hken_US
dc.identifier.authorityYue, J=rp00286en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3390/molecules17044343en_US
dc.identifier.pmid22491682-
dc.identifier.scopuseid_2-s2.0-84860257725en_US
dc.identifier.hkuros208768-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860257725&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.spage4343en_US
dc.identifier.epage4356en_US
dc.identifier.isiWOS:000303309900051-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridZhou, Y=55199306000en_US
dc.identifier.scopusauthoridYu, P=55034912300en_US
dc.identifier.scopusauthoridJin, H=36561657200en_US
dc.identifier.scopusauthoridYang, Z=7405435277en_US
dc.identifier.scopusauthoridYue, J=7101875828en_US
dc.identifier.scopusauthoridZhang, L=8833065300en_US
dc.identifier.scopusauthoridZhang, L=15040200600en_US

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