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Article: Cutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation

TitleCutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation
Authors
Issue Date2010
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2010, v. 184 n. 9, p. 4625-4629 How to Cite?
AbstractDuring priming, CD8 + T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8 + T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent "effector" DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. Copyright © 2010 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171781
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMin, Len_US
dc.contributor.authorIsa, SABMen_US
dc.contributor.authorShuai, Wen_US
dc.contributor.authorPiang, CBen_US
dc.contributor.authorNih, FWen_US
dc.contributor.authorKotaka, Men_US
dc.contributor.authorRuedl, Cen_US
dc.date.accessioned2012-10-30T06:17:03Z-
dc.date.available2012-10-30T06:17:03Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Immunology, 2010, v. 184 n. 9, p. 4625-4629en_US
dc.identifier.issn0022-1767en_US
dc.identifier.urihttp://hdl.handle.net/10722/171781-
dc.description.abstractDuring priming, CD8 + T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8 + T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent "effector" DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. Copyright © 2010 by The American Association of Immunologists, Inc.en_US
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.titleCutting edge: Granulocyte-macrophage colony-stimulating factor is the major CD8 + T cell-derived licensing factor for dendritic cell activationen_US
dc.typeArticleen_US
dc.identifier.emailKotaka, M:masayo@hku.hken_US
dc.identifier.authorityKotaka, M=rp00293en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.0903873en_US
dc.identifier.pmid20357255-
dc.identifier.scopuseid_2-s2.0-77954497180en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954497180&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume184en_US
dc.identifier.issue9en_US
dc.identifier.spage4625en_US
dc.identifier.epage4629en_US
dc.identifier.isiWOS:000277093000011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMin, L=36189351800en_US
dc.identifier.scopusauthoridIsa, SABM=36452913600en_US
dc.identifier.scopusauthoridShuai, W=23010818500en_US
dc.identifier.scopusauthoridPiang, CB=36167177400en_US
dc.identifier.scopusauthoridNih, FW=36167079200en_US
dc.identifier.scopusauthoridKotaka, M=6604073578en_US
dc.identifier.scopusauthoridRuedl, C=6603812935en_US

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