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Article: Reprint of "frequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pig" [Neuroscience 151 (2008) 293-302]{star, open}

TitleReprint of "frequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pig" [Neuroscience 151 (2008) 293-302]{star, open}
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2008, v. 154 n. 1, p. 273-282 How to Cite?
AbstractWe investigated the firing pattern and frequency tuning properties of medial geniculate body (MGB) neurons, through in vivo intracellular recordings in anesthetized guinea pigs. Twenty-two of the 25 physiological characterized neurons were anatomically identified. Ten neurons were located in the ventral division of the medial geniculate body (MGv) (seven in pars ovoidea (OV) and three in the pars lateralis (LV)). Eight were located in the dorsal division (MGd), and four in the medial division (MGm). OV neurons showed a uniform, phasic ON response with high frequency selectivity. Functionally, they are interpreted as relaying spectral information with high reliability. LV neurons exhibited various patterns: phasic, tonic and excitatory postsynaptic potentials (EPSP) with a spike train. These high magnitude EPSPs are proposed to convey temporal information of the auditory signals with more encoding power. MGd neurons had relatively low best frequencies while MGm neurons had high intensity threshold, broader frequency selectivity, and a tonic response pattern. Tonic firing is likely to impose a strong impact onto wide cortical area and amygdala. When hyperpolarized with current injection, MGB neurons evoked low-threshold calcium spikes. Distinct change in these spike numbers was observed among MGv and MGd neurons as compared with MGm neurons, implying their differential roles. MGm neurons are more modulatory in nature, while the long lasting bursts of low-threshold calcium spikes observed in MGv and MGd neurons probably participate in propagating the sleep oscillations. © 2008 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/171766
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_US
dc.contributor.authorYu, YQen_US
dc.contributor.authorLiu, CHen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorHe, Jen_US
dc.date.accessioned2012-10-30T06:16:54Z-
dc.date.available2012-10-30T06:16:54Z-
dc.date.issued2008en_US
dc.identifier.citationNeuroscience, 2008, v. 154 n. 1, p. 273-282en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/171766-
dc.description.abstractWe investigated the firing pattern and frequency tuning properties of medial geniculate body (MGB) neurons, through in vivo intracellular recordings in anesthetized guinea pigs. Twenty-two of the 25 physiological characterized neurons were anatomically identified. Ten neurons were located in the ventral division of the medial geniculate body (MGv) (seven in pars ovoidea (OV) and three in the pars lateralis (LV)). Eight were located in the dorsal division (MGd), and four in the medial division (MGm). OV neurons showed a uniform, phasic ON response with high frequency selectivity. Functionally, they are interpreted as relaying spectral information with high reliability. LV neurons exhibited various patterns: phasic, tonic and excitatory postsynaptic potentials (EPSP) with a spike train. These high magnitude EPSPs are proposed to convey temporal information of the auditory signals with more encoding power. MGd neurons had relatively low best frequencies while MGm neurons had high intensity threshold, broader frequency selectivity, and a tonic response pattern. Tonic firing is likely to impose a strong impact onto wide cortical area and amygdala. When hyperpolarized with current injection, MGB neurons evoked low-threshold calcium spikes. Distinct change in these spike numbers was observed among MGv and MGd neurons as compared with MGm neurons, implying their differential roles. MGm neurons are more modulatory in nature, while the long lasting bursts of low-threshold calcium spikes observed in MGv and MGd neurons probably participate in propagating the sleep oscillations. © 2008 IBRO.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.subject.meshAcoustic Stimulation - Methodsen_US
dc.subject.meshAction Potentials - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAuditory Pathways - Physiologyen_US
dc.subject.meshAuditory Perception - Physiologyen_US
dc.subject.meshAuditory Threshold - Physiologyen_US
dc.subject.meshExcitatory Postsynaptic Potentials - Physiology - Radiation Effectsen_US
dc.subject.meshGeniculate Bodies - Cytologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshNeurons - Classification - Physiologyen_US
dc.titleReprint of "frequency tuning and firing pattern properties of auditory thalamic neurons: An in vivo intracellular recording from the guinea pig" [Neuroscience 151 (2008) 293-302]{star, open}en_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0306-4522(08)00741-0en_US
dc.identifier.pmid18555163-
dc.identifier.scopuseid_2-s2.0-44849141860en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44849141860&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume154en_US
dc.identifier.issue1en_US
dc.identifier.spage273en_US
dc.identifier.epage282en_US
dc.identifier.isiWOS:000256872300024-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhang, Z=23053543300en_US
dc.identifier.scopusauthoridYu, YQ=7406253532en_US
dc.identifier.scopusauthoridLiu, CH=54970746700en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridHe, J=7404984971en_US

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