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Article: Adrenomedullin gene expression and peptide levels in the heart and blood vessels of streptozotocin-diabetic rats

TitleAdrenomedullin gene expression and peptide levels in the heart and blood vessels of streptozotocin-diabetic rats
Authors
Issue Date2007
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmr
Citation
Hormone And Metabolic Research, 2007, v. 39 n. 1, p. 3-8 How to Cite?
AbstractThe aim of the present study was to assess the changes in gene expression and peptide adrenomedullin (AM) levels in cardiovascular and other tissues in the streptozotocin-diabetic rats. For this purpose, diabetes was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg/Kg body weight). Half of the diabetic rats were subcutaneously injected with insulin in the afternoon (4 units/day) one week after STZ injection until the day before killing. Control rats received only saline injection. AM mRNA was determined in cardiovascular and other tissues of streptozotocin-diabetic rats using solution-hybridization- RNase protection assay. Circulating AM and peptide AM in cardiovascular and other tissues were estimated using a specific radioimmunoassay. There were increases in preproAM mRNA levels in the left and right ventricles and in the thoracic aorta in both the 2-week and 4-week diabetic rats, but not in the two atria, the mesenteric artery and the lung. In the 2-week diabetic rats, there were decreases in AM contents in the two atria and the lung but an increase in the thoracic aorta. In the 4-week diabetic rats, there were bigger decreases in the atria and also a decrease in the left ventricle. The plasma AM levels were not changed but there was an increase in the excretion of AM in the urine. Our results suggest a possible increase in AM release in the heart and the thoracic aorta in the 2-week and 4-week diabetic rats. © Georg Thieme Verlag KG Stuttgart.
Persistent Identifierhttp://hdl.handle.net/10722/171755
ISSN
2015 Impact Factor: 2.029
2015 SCImago Journal Rankings: 0.846
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorHwang, ISSen_US
dc.contributor.authorWong, MPFen_US
dc.contributor.authorLi, YYen_US
dc.date.accessioned2012-10-30T06:16:48Z-
dc.date.available2012-10-30T06:16:48Z-
dc.date.issued2007en_US
dc.identifier.citationHormone And Metabolic Research, 2007, v. 39 n. 1, p. 3-8en_US
dc.identifier.issn0018-5043en_US
dc.identifier.urihttp://hdl.handle.net/10722/171755-
dc.description.abstractThe aim of the present study was to assess the changes in gene expression and peptide adrenomedullin (AM) levels in cardiovascular and other tissues in the streptozotocin-diabetic rats. For this purpose, diabetes was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg/Kg body weight). Half of the diabetic rats were subcutaneously injected with insulin in the afternoon (4 units/day) one week after STZ injection until the day before killing. Control rats received only saline injection. AM mRNA was determined in cardiovascular and other tissues of streptozotocin-diabetic rats using solution-hybridization- RNase protection assay. Circulating AM and peptide AM in cardiovascular and other tissues were estimated using a specific radioimmunoassay. There were increases in preproAM mRNA levels in the left and right ventricles and in the thoracic aorta in both the 2-week and 4-week diabetic rats, but not in the two atria, the mesenteric artery and the lung. In the 2-week diabetic rats, there were decreases in AM contents in the two atria and the lung but an increase in the thoracic aorta. In the 4-week diabetic rats, there were bigger decreases in the atria and also a decrease in the left ventricle. The plasma AM levels were not changed but there was an increase in the excretion of AM in the urine. Our results suggest a possible increase in AM release in the heart and the thoracic aorta in the 2-week and 4-week diabetic rats. © Georg Thieme Verlag KG Stuttgart.en_US
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/hmren_US
dc.relation.ispartofHormone and Metabolic Researchen_US
dc.rightsHormone and Metabolic Research. Copyright © Georg Thieme Verlag.-
dc.subject.meshAdrenomedullin - Blood - Genetics - Metabolism - Urineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Metabolismen_US
dc.subject.meshBlood Vessels - Chemistry - Metabolismen_US
dc.subject.meshDiabetes Mellitus, Experimental - Blood - Metabolism - Urineen_US
dc.subject.meshHeart Ventricles - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMesenteric Arteries - Metabolismen_US
dc.subject.meshMyocardium - Chemistry - Metabolismen_US
dc.subject.meshPeptides - Analysisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStreptozocinen_US
dc.titleAdrenomedullin gene expression and peptide levels in the heart and blood vessels of streptozotocin-diabetic ratsen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.emailHwang, ISS: isabelbelbel@hotmail.com-
dc.identifier.emailWong, PF: pfwong@HKUSUA.hku.hk-
dc.identifier.emailLi, YY: cyyli@graduate.hku.hk-
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-2007-956517en_US
dc.identifier.pmid17226106-
dc.identifier.scopuseid_2-s2.0-33947575822en_US
dc.identifier.hkuros136865-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947575822&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue1en_US
dc.identifier.spage3en_US
dc.identifier.epage8en_US
dc.identifier.isiWOS:000243967300002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridHwang, ISS=7201615103en_US
dc.identifier.scopusauthoridWong, MPF=36985740400en_US
dc.identifier.scopusauthoridLi, YY=26661428600en_US

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