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Article: The cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integration

TitleThe cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integration
Authors
KeywordsCerebellohypothalamic projection
Cerebellum
Histaminergic fiber
Hypothalamocerebellar projection
Somatic-visceral integration
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresrev
Citation
Brain Research Reviews, 2006, v. 52 n. 1, p. 93-106 How to Cite?
AbstractThe cerebellum has been considered only as a classical subcortical center for motor control. However, accumulating experimental and clinical evidences have revealed that the cerebellum also plays an important role in cognition, for instance, in learning and memory, as well as in emotional behavior and in nonsomatic activities, such as visceral and immunological responses. Although it is not yet clear through which pathways such cerebellar nonsomatic functions are mediated, the direct bidirectional connections between the cerebellum and the hypothalamus, a high autonomic center, have recently been demonstrated in a series of neuroanatomical investigations on a variety of mammals and indicated to be potential pathways underlying the cerebellar autonomic modulation. The direct hypothalamocerebellar projections originate from the widespread hypothalamic nuclei/areas and terminate in both the cerebellar cortex as multilayered fibers and the cerebellar nuclei. Immunohistochemistry studies have offered fairly convincing evidence that some of these projecting fibers are histaminergic. It has been suggested that through their excitatory effects on cerebellar cortical and nuclear cells mediated by metabotropic histamine H2 and/or H1 receptors, the hypothalamocerebellar histaminergic fibers participate in cerebellar modulation of somatic motor as well as non-motor responses. On the other hand, the direct cerebellohypothalamic projections arise from all cerebellar nuclei (fastigial, anterior and posterior interpositus, and dentate nuclei) and reach almost all hypothalamic nuclei/areas. Neurophysiological and neuroimaging studies have demonstrated that these connections may be involved in feeding, cardiovascular, osmotic, respiratory, micturition, immune, emotion, and other nonsomatic regulation. These observations provide support for the hypothesis that the cerebellum is an essential modulator and coordinator for integrating motor, visceral and behavioral responses, and that such somatic-visceral integration through the cerebellar circuitry may be fulfilled by means of the cerebellar-hypothalamic circuits. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171746
ISSN
2013 Impact Factor: 5.93
2014 SCImago Journal Rankings: 2.982
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, JNen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorKwokChong Chow, Ben_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorWang, JJen_HK
dc.date.accessioned2012-10-30T06:16:45Z-
dc.date.available2012-10-30T06:16:45Z-
dc.date.issued2006en_HK
dc.identifier.citationBrain Research Reviews, 2006, v. 52 n. 1, p. 93-106en_HK
dc.identifier.issn0165-0173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/171746-
dc.description.abstractThe cerebellum has been considered only as a classical subcortical center for motor control. However, accumulating experimental and clinical evidences have revealed that the cerebellum also plays an important role in cognition, for instance, in learning and memory, as well as in emotional behavior and in nonsomatic activities, such as visceral and immunological responses. Although it is not yet clear through which pathways such cerebellar nonsomatic functions are mediated, the direct bidirectional connections between the cerebellum and the hypothalamus, a high autonomic center, have recently been demonstrated in a series of neuroanatomical investigations on a variety of mammals and indicated to be potential pathways underlying the cerebellar autonomic modulation. The direct hypothalamocerebellar projections originate from the widespread hypothalamic nuclei/areas and terminate in both the cerebellar cortex as multilayered fibers and the cerebellar nuclei. Immunohistochemistry studies have offered fairly convincing evidence that some of these projecting fibers are histaminergic. It has been suggested that through their excitatory effects on cerebellar cortical and nuclear cells mediated by metabotropic histamine H2 and/or H1 receptors, the hypothalamocerebellar histaminergic fibers participate in cerebellar modulation of somatic motor as well as non-motor responses. On the other hand, the direct cerebellohypothalamic projections arise from all cerebellar nuclei (fastigial, anterior and posterior interpositus, and dentate nuclei) and reach almost all hypothalamic nuclei/areas. Neurophysiological and neuroimaging studies have demonstrated that these connections may be involved in feeding, cardiovascular, osmotic, respiratory, micturition, immune, emotion, and other nonsomatic regulation. These observations provide support for the hypothesis that the cerebellum is an essential modulator and coordinator for integrating motor, visceral and behavioral responses, and that such somatic-visceral integration through the cerebellar circuitry may be fulfilled by means of the cerebellar-hypothalamic circuits. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresreven_HK
dc.relation.ispartofBrain Research Reviewsen_HK
dc.rightsBrain Research Reviews. Copyright © Elsevier BV.-
dc.subjectCerebellohypothalamic projectionen_HK
dc.subjectCerebellumen_HK
dc.subjectHistaminergic fiberen_HK
dc.subjectHypothalamocerebellar projectionen_HK
dc.subjectSomatic-visceral integrationen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCardiovascular Physiological Phenomenaen_US
dc.subject.meshCerebellum - Anatomy & Histology - Physiologyen_US
dc.subject.meshFeeding Behavior - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothalamus - Anatomy & Histology - Physiologyen_US
dc.subject.meshImmunity - Physiologyen_US
dc.subject.meshLearningen_US
dc.subject.meshNerve Net - Physiologyen_US
dc.subject.meshVisceral Afferents - Physiologyen_US
dc.titleThe cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integrationen_HK
dc.typeArticleen_HK
dc.identifier.emailKwokChong Chow, B: bkcc@hku.hken_HK
dc.identifier.emailChan, YS: yschan@hku.hken_HK
dc.identifier.authorityKwokChong Chow, B=rp00681en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainresrev.2006.01.003en_HK
dc.identifier.pmid16497381-
dc.identifier.scopuseid_2-s2.0-33746041790en_HK
dc.identifier.hkuros121714-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746041790&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage93en_HK
dc.identifier.epage106en_HK
dc.identifier.isiWOS:000239683600004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhu, JN=9279857000en_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridKwokChong Chow, B=7102826193en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridWang, JJ=9841895000en_HK

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