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Article: Differential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of rats

TitleDifferential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of rats
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
Neuroscience Research, 2004, v. 49 n. 3, p. 281-288 How to Cite?
AbstractPrevious evidence has suggested that glutamate-driving neurotransmission and glutamate-excitotoxicity are modulated by substance P in the basal ganglia, but the assembly of glutamate receptors mediating this process remains to be delineated. By using a double immunofluorescence, cellular expression of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits (GluR1-4) in substance P receptor (SPR)-containing neurons was examined in the striatum of rats. It revealed that distribution of SPR-immunoreactive neurons completely overlapped with that of GluR1, 2, 3 or 4-immunoreactive neurons in the caudate-putamen. Neurons showing both SPR and AMPA receptor subunits (except of GluR3)-immunoreactivity were observed: all (100%) of SPR-positive neurons displayed GluR1-, GluR2- or GluR4-immunoreactivity, and the double-labeled neurons constituted about 33, 3 or 29% of total GluR-positive ones. In contrast, the neurons exhibiting both SPR- and GluR3-immunoreactivity were not detected, though numerous GluR3-positive neurons were still distributed in the caudate-putamen regions. Co-localization of SPR and distinct AMPA receptor subunits in the striatal neurons has provided a basis for functional modulation of neuronal APMA receptors by substance P in the caudate-putamen of rodents. Taken together with previous observations, this study has also suggested that, through interaction with AMPA receptors composed of subunits 1, 2 and 4, substance P or neurokinin peptides may play important roles in regulating neuronal properties and protecting neurons from excitotoxicity in the basal ganglia of mammals. © 2004 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171740
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, HJen_US
dc.contributor.authorChen, LWen_US
dc.contributor.authorYung, KKLen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2012-10-30T06:16:43Z-
dc.date.available2012-10-30T06:16:43Z-
dc.date.issued2004en_US
dc.identifier.citationNeuroscience Research, 2004, v. 49 n. 3, p. 281-288en_US
dc.identifier.issn0168-0102en_US
dc.identifier.urihttp://hdl.handle.net/10722/171740-
dc.description.abstractPrevious evidence has suggested that glutamate-driving neurotransmission and glutamate-excitotoxicity are modulated by substance P in the basal ganglia, but the assembly of glutamate receptors mediating this process remains to be delineated. By using a double immunofluorescence, cellular expression of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits (GluR1-4) in substance P receptor (SPR)-containing neurons was examined in the striatum of rats. It revealed that distribution of SPR-immunoreactive neurons completely overlapped with that of GluR1, 2, 3 or 4-immunoreactive neurons in the caudate-putamen. Neurons showing both SPR and AMPA receptor subunits (except of GluR3)-immunoreactivity were observed: all (100%) of SPR-positive neurons displayed GluR1-, GluR2- or GluR4-immunoreactivity, and the double-labeled neurons constituted about 33, 3 or 29% of total GluR-positive ones. In contrast, the neurons exhibiting both SPR- and GluR3-immunoreactivity were not detected, though numerous GluR3-positive neurons were still distributed in the caudate-putamen regions. Co-localization of SPR and distinct AMPA receptor subunits in the striatal neurons has provided a basis for functional modulation of neuronal APMA receptors by substance P in the caudate-putamen of rodents. Taken together with previous observations, this study has also suggested that, through interaction with AMPA receptors composed of subunits 1, 2 and 4, substance P or neurokinin peptides may play important roles in regulating neuronal properties and protecting neurons from excitotoxicity in the basal ganglia of mammals. © 2004 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuresen_US
dc.relation.ispartofNeuroscience Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCaudate Nucleus - Cytologyen_US
dc.subject.meshGene Expression Regulation - Physiologyen_US
dc.subject.meshImmunohistochemistry - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshNeostriatum - Cytology - Metabolismen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshProtein Subunits - Metabolismen_US
dc.subject.meshPutamen - Cytologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Ampa - Metabolismen_US
dc.subject.meshReceptors, Neurokinin-1 - Metabolismen_US
dc.titleDifferential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of ratsen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neures.2004.03.003en_US
dc.identifier.pmid15196776-
dc.identifier.scopuseid_2-s2.0-2942530965en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942530965&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue3en_US
dc.identifier.spage281en_US
dc.identifier.epage288en_US
dc.identifier.isiWOS:000222516100002-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridHu, HJ=8683277000en_US
dc.identifier.scopusauthoridChen, LW=15821717100en_US
dc.identifier.scopusauthoridYung, KKL=13605496000en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US

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