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- Publisher Website: 10.1146/annurev.pharmtox.41.1.317
- Scopus: eid_2-s2.0-0035033022
- PMID: 11264460
- WOS: WOS:000168439400013
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Article: Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Title | Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers |
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Authors | |
Keywords | ADP-ribosyl cyclase Ca2+stores cADPR CD38 Inositol trisphosphate Ryanodine receptor |
Issue Date | 2001 |
Publisher | Annual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/pharmtox |
Citation | Annual Review Of Pharmacology And Toxicology, 2001, v. 41, p. 317-345 How to Cite? |
Abstract | Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. The crystal structure of the cyclase has been solved and its active site identified. These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain. A battery of pharmacological reagents have been developed, providing valuable tools for elucidating the physiological functions of these two novel Ca2+ messengers. This article reviews these recent results and explores the implications of the existence of multiple Ca2+ messengers and Ca2+ stores in cells. |
Persistent Identifier | http://hdl.handle.net/10722/171691 |
ISSN | 2023 Impact Factor: 11.2 2023 SCImago Journal Rankings: 3.957 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HC | en_US |
dc.date.accessioned | 2012-10-30T06:16:23Z | - |
dc.date.available | 2012-10-30T06:16:23Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Annual Review Of Pharmacology And Toxicology, 2001, v. 41, p. 317-345 | en_US |
dc.identifier.issn | 0362-1642 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171691 | - |
dc.description.abstract | Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. The crystal structure of the cyclase has been solved and its active site identified. These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain. A battery of pharmacological reagents have been developed, providing valuable tools for elucidating the physiological functions of these two novel Ca2+ messengers. This article reviews these recent results and explores the implications of the existence of multiple Ca2+ messengers and Ca2+ stores in cells. | en_US |
dc.language | eng | en_US |
dc.publisher | Annual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/pharmtox | en_US |
dc.relation.ispartof | Annual Review of Pharmacology and Toxicology | en_US |
dc.subject | ADP-ribosyl cyclase | - |
dc.subject | Ca2+stores | - |
dc.subject | cADPR | - |
dc.subject | CD38 | - |
dc.subject | Inositol trisphosphate | - |
dc.subject | Ryanodine receptor | - |
dc.subject.mesh | Adenosine Diphosphate Ribose - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium - Physiology | en_US |
dc.subject.mesh | Calcium Signaling - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Nadp - Analogs & Derivatives - Physiology | en_US |
dc.title | Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
dc.identifier.authority | Lee, HC=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1146/annurev.pharmtox.41.1.317 | en_US |
dc.identifier.pmid | 11264460 | - |
dc.identifier.scopus | eid_2-s2.0-0035033022 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035033022&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 41 | en_US |
dc.identifier.spage | 317 | en_US |
dc.identifier.epage | 345 | en_US |
dc.identifier.isi | WOS:000168439400013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
dc.identifier.issnl | 0362-1642 | - |