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Article: Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers

TitlePhysiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Authors
Issue Date2001
PublisherAnnual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/pharmtox
Citation
Annual Review Of Pharmacology And Toxicology, 2001, v. 41, p. 317-345 How to Cite?
AbstractCyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. The crystal structure of the cyclase has been solved and its active site identified. These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain. A battery of pharmacological reagents have been developed, providing valuable tools for elucidating the physiological functions of these two novel Ca2+ messengers. This article reviews these recent results and explores the implications of the existence of multiple Ca2+ messengers and Ca2+ stores in cells.
Persistent Identifierhttp://hdl.handle.net/10722/171691
ISSN
2015 Impact Factor: 14.769
2015 SCImago Journal Rankings: 8.645
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, HCen_US
dc.date.accessioned2012-10-30T06:16:23Z-
dc.date.available2012-10-30T06:16:23Z-
dc.date.issued2001en_US
dc.identifier.citationAnnual Review Of Pharmacology And Toxicology, 2001, v. 41, p. 317-345en_US
dc.identifier.issn0362-1642en_US
dc.identifier.urihttp://hdl.handle.net/10722/171691-
dc.description.abstractCyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. The crystal structure of the cyclase has been solved and its active site identified. These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain. A battery of pharmacological reagents have been developed, providing valuable tools for elucidating the physiological functions of these two novel Ca2+ messengers. This article reviews these recent results and explores the implications of the existence of multiple Ca2+ messengers and Ca2+ stores in cells.en_US
dc.languageengen_US
dc.publisherAnnual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/pharmtoxen_US
dc.relation.ispartofAnnual Review of Pharmacology and Toxicologyen_US
dc.subject.meshAdenosine Diphosphate Ribose - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCalcium Signaling - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshNadp - Analogs & Derivatives - Physiologyen_US
dc.titlePhysiological functions of cyclic ADP-ribose and NAADP as calcium messengersen_US
dc.typeArticleen_US
dc.identifier.emailLee, HC:leehc@hku.hken_US
dc.identifier.authorityLee, HC=rp00545en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1146/annurev.pharmtox.41.1.317en_US
dc.identifier.pmid11264460-
dc.identifier.scopuseid_2-s2.0-0035033022en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035033022&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.spage317en_US
dc.identifier.epage345en_US
dc.identifier.isiWOS:000168439400013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, HC=26642959100en_US

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