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Article: Elfin is expressed during early heart development

TitleElfin is expressed during early heart development
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503
Citation
Journal Of Cellular Biochemistry, 2001, v. 83 n. 3, p. 463-472 How to Cite?
AbstractElfin (previously named CLIM1) is a protein that possesses an N-terminal PDZ domain and a C-terminal LIM domain. It belongs to the family of Enigma proteins. Enigma proteins are a family of Cytoplasmic proteins that contain an N-terminal PDZ domain and a series of C-terminal LIM domains. By virtue of these two protein interacting domains, Enigma proteins are capable of protein-protein interactions. It has been proposed that Enigma proteins may act as adapters between kinases and the cytoskeleton. We have previously shown that Elfin is most abundantly expressed in the heart and it colocalizes with α-actinin 2 at the Z-disks of the myocardium. In this report, Elfin was shown to localize at the actin stress fibers of myoblasts, as revealed by green fluorescent protein (GFP) tagging. In situ hybridization and immunostaining showed that Elfin expression begins at an early stage in mouse development and is present throughout the developing heart. Taken together, our experimental results suggest that Elfin may play an important role in myofibrillogenesis and heart development. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171688
ISSN
2015 Impact Factor: 3.446
2015 SCImago Journal Rankings: 1.520
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKotaka, Men_US
dc.contributor.authorLau, YMen_US
dc.contributor.authorCheung, KKen_US
dc.contributor.authorLee, SMYen_US
dc.contributor.authorLi, HYen_US
dc.contributor.authorChan, WYen_US
dc.contributor.authorFung, KPen_US
dc.contributor.authorLee, CYen_US
dc.contributor.authorWaye, MMYen_US
dc.contributor.authorTsui, SKWen_US
dc.date.accessioned2012-10-30T06:16:22Z-
dc.date.available2012-10-30T06:16:22Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Cellular Biochemistry, 2001, v. 83 n. 3, p. 463-472en_US
dc.identifier.issn0730-2312en_US
dc.identifier.urihttp://hdl.handle.net/10722/171688-
dc.description.abstractElfin (previously named CLIM1) is a protein that possesses an N-terminal PDZ domain and a C-terminal LIM domain. It belongs to the family of Enigma proteins. Enigma proteins are a family of Cytoplasmic proteins that contain an N-terminal PDZ domain and a series of C-terminal LIM domains. By virtue of these two protein interacting domains, Enigma proteins are capable of protein-protein interactions. It has been proposed that Enigma proteins may act as adapters between kinases and the cytoskeleton. We have previously shown that Elfin is most abundantly expressed in the heart and it colocalizes with α-actinin 2 at the Z-disks of the myocardium. In this report, Elfin was shown to localize at the actin stress fibers of myoblasts, as revealed by green fluorescent protein (GFP) tagging. In situ hybridization and immunostaining showed that Elfin expression begins at an early stage in mouse development and is present throughout the developing heart. Taken together, our experimental results suggest that Elfin may play an important role in myofibrillogenesis and heart development. © 2001 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503en_US
dc.relation.ispartofJournal of Cellular Biochemistryen_US
dc.subject.meshActinin - Metabolismen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCytoplasm - Metabolismen_US
dc.subject.meshCytoskeleton - Metabolismen_US
dc.subject.meshDna, Complementary - Metabolismen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshGreen Fluorescent Proteinsen_US
dc.subject.meshHeart - Embryologyen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLim Domain Proteinsen_US
dc.subject.meshLuminescent Proteins - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshProtein Structure, Tertiaryen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshStress Fibers - Metabolismen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshTranscription Factors - Biosynthesis - Chemistryen_US
dc.titleElfin is expressed during early heart developmenten_US
dc.typeArticleen_US
dc.identifier.emailKotaka, M:masayo@hku.hken_US
dc.identifier.authorityKotaka, M=rp00293en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jcb.1244en_US
dc.identifier.pmid11596114-
dc.identifier.scopuseid_2-s2.0-0034759485en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034759485&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume83en_US
dc.identifier.issue3en_US
dc.identifier.spage463en_US
dc.identifier.epage472en_US
dc.identifier.isiWOS:000171977500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKotaka, M=6604073578en_US
dc.identifier.scopusauthoridLau, YM=14420993500en_US
dc.identifier.scopusauthoridCheung, KK=7402406736en_US
dc.identifier.scopusauthoridLee, SMY=35233892600en_US
dc.identifier.scopusauthoridLi, HY=12762326800en_US
dc.identifier.scopusauthoridChan, WY=13310314800en_US
dc.identifier.scopusauthoridFung, KP=35271657800en_US
dc.identifier.scopusauthoridLee, CY=7410142857en_US
dc.identifier.scopusauthoridWaye, MMY=7006687733en_US
dc.identifier.scopusauthoridTsui, SKW=7004961364en_US

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