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Article: Cholinergic lesions of the rat brain by ibotenic acid and 192 igG- saporin: Effects on somatostatin, substance P and neuropeptide Y levels in the cerebral cortex and the hippocampus

TitleCholinergic lesions of the rat brain by ibotenic acid and 192 igG- saporin: Effects on somatostatin, substance P and neuropeptide Y levels in the cerebral cortex and the hippocampus
Authors
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1998, v. 252 n. 2, p. 83-86 How to Cite?
AbstractImpairment of the basal forebrain cholinergic system is an important change in the brains of Alzheimer's disease patients. Various neurotoxins have been used to achieve this in animal models. In this study the effects of chemical lesions by ibotenic acid (IBO), a glutamate analogue and by 192 IgG- saporin, a highly specific immunotoxin against cholinergic neurons, were investigated. The toxins were delivered stereotaxically into the brains of young Sprague-Dawley rats which were later sacrificed by decapitation. Choline acetyltransferase (ChAT) activity was measured by radioenzymatic assay and substance P (SP), neuropeptide Y (NPY) and somatostatin (SOM) levels by radioimmunoassay. Decreased ChAT and SOM levels were observed in the cortex and the hippocampus in both experiments. Cortical SP levels were increased after IBO lesions but were unaffected after 192 IgG-saporin lesions. NPY levels remained unchanged in both experiments. The results indicate that there were specific changes in neuropeptide contents in the cortex and hippocampus in response to cholinergic damage in the rat brain.
Persistent Identifierhttp://hdl.handle.net/10722/171659
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNag, Sen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:16:12Z-
dc.date.available2012-10-30T06:16:12Z-
dc.date.issued1998en_US
dc.identifier.citationNeuroscience Letters, 1998, v. 252 n. 2, p. 83-86en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/171659-
dc.description.abstractImpairment of the basal forebrain cholinergic system is an important change in the brains of Alzheimer's disease patients. Various neurotoxins have been used to achieve this in animal models. In this study the effects of chemical lesions by ibotenic acid (IBO), a glutamate analogue and by 192 IgG- saporin, a highly specific immunotoxin against cholinergic neurons, were investigated. The toxins were delivered stereotaxically into the brains of young Sprague-Dawley rats which were later sacrificed by decapitation. Choline acetyltransferase (ChAT) activity was measured by radioenzymatic assay and substance P (SP), neuropeptide Y (NPY) and somatostatin (SOM) levels by radioimmunoassay. Decreased ChAT and SOM levels were observed in the cortex and the hippocampus in both experiments. Cortical SP levels were increased after IBO lesions but were unaffected after 192 IgG-saporin lesions. NPY levels remained unchanged in both experiments. The results indicate that there were specific changes in neuropeptide contents in the cortex and hippocampus in response to cholinergic damage in the rat brain.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.-
dc.subject.meshAlzheimer Disease - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonalen_US
dc.subject.meshBehavior, Animal - Drug Effectsen_US
dc.subject.meshBrain Chemistry - Drug Effectsen_US
dc.subject.meshCerebral Cortex - Chemistry - Enzymologyen_US
dc.subject.meshCholine O-Acetyltransferase - Metabolismen_US
dc.subject.meshCholinergic Agentsen_US
dc.subject.meshCholinergic Fibers - Chemistry - Drug Effects - Enzymologyen_US
dc.subject.meshExcitatory Amino Acid Agonistsen_US
dc.subject.meshHippocampus - Chemistry - Enzymologyen_US
dc.subject.meshIbotenic Aciden_US
dc.subject.meshImmunotoxinsen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learning - Drug Effectsen_US
dc.subject.meshN-Glycosyl Hydrolasesen_US
dc.subject.meshNeuropeptide Y - Analysis - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRibosome Inactivating Proteins, Type 1en_US
dc.subject.meshSomatostatin - Analysis - Metabolismen_US
dc.subject.meshSubstance P - Analysis - Metabolismen_US
dc.titleCholinergic lesions of the rat brain by ibotenic acid and 192 igG- saporin: Effects on somatostatin, substance P and neuropeptide Y levels in the cerebral cortex and the hippocampusen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(98)00545-Xen_US
dc.identifier.pmid9756327-
dc.identifier.scopuseid_2-s2.0-0032563342en_US
dc.identifier.hkuros36708-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032563342&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume252en_US
dc.identifier.issue2en_US
dc.identifier.spage83en_US
dc.identifier.epage86en_US
dc.identifier.isiWOS:000075543200003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridNag, S=7103093193en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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