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- Publisher Website: 10.1038/nsb1196-957
- Scopus: eid_2-s2.0-0029858306
- PMID: 8901875
- WOS: WOS:A1996VT09300016
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Article: Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38
Title | Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38 |
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Authors | |
Issue Date | 1996 |
Citation | Nature Structural Biology, 1996, v. 3 n. 11, p. 957-964 How to Cite? |
Abstract | ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose. |
Persistent Identifier | http://hdl.handle.net/10722/171627 |
ISSN | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Prasad, GS | en_US |
dc.contributor.author | Mcree, DE | en_US |
dc.contributor.author | Stura, EA | en_US |
dc.contributor.author | Levitt, DG | en_US |
dc.contributor.author | Lee, HC | en_US |
dc.contributor.author | Stout, CD | en_US |
dc.date.accessioned | 2012-10-30T06:16:02Z | - |
dc.date.available | 2012-10-30T06:16:02Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Nature Structural Biology, 1996, v. 3 n. 11, p. 957-964 | en_US |
dc.identifier.issn | 1072-8368 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171627 | - |
dc.description.abstract | ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Nature Structural Biology | en_US |
dc.subject.mesh | Adp-Ribosyl Cyclase | en_US |
dc.subject.mesh | Adenosine Diphosphate Ribose - Metabolism | en_US |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antigens, Cd | en_US |
dc.subject.mesh | Antigens, Cd38 | en_US |
dc.subject.mesh | Antigens, Differentiation - Chemistry | en_US |
dc.subject.mesh | Aplysia - Enzymology | en_US |
dc.subject.mesh | Conserved Sequence | en_US |
dc.subject.mesh | Crystallography, X-Ray | en_US |
dc.subject.mesh | Dimerization | en_US |
dc.subject.mesh | Gpi-Linked Proteins | en_US |
dc.subject.mesh | Membrane Glycoproteins - Chemistry | en_US |
dc.subject.mesh | Models, Molecular | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | N-Glycosyl Hydrolases - Chemistry | en_US |
dc.subject.mesh | Protein Conformation | en_US |
dc.subject.mesh | Sequence Homology, Amino Acid | en_US |
dc.title | Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
dc.identifier.authority | Lee, HC=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/nsb1196-957 | en_US |
dc.identifier.pmid | 8901875 | - |
dc.identifier.scopus | eid_2-s2.0-0029858306 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029858306&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 957 | en_US |
dc.identifier.epage | 964 | en_US |
dc.identifier.isi | WOS:A1996VT09300016 | - |
dc.identifier.scopusauthorid | Prasad, GS=7201752888 | en_US |
dc.identifier.scopusauthorid | McRee, DE=7006894969 | en_US |
dc.identifier.scopusauthorid | Stura, EA=7006685217 | en_US |
dc.identifier.scopusauthorid | Levitt, DG=7102923276 | en_US |
dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
dc.identifier.scopusauthorid | Stout, CD=7102760401 | en_US |
dc.identifier.issnl | 1072-8368 | - |