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Article: The functional expression of a pontine pneumotaxic centre in neonatal rats

TitleThe functional expression of a pontine pneumotaxic centre in neonatal rats
Authors
Issue Date1995
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 1995, v. 489 n. 2, p. 579-591 How to Cite?
Abstract1. Our purpose was to determine whether a pneumotaxic centre could be localized to the rostral. pens in newborn rats. We recorded efferent activity of the phrenic nerve in decerebrate, paralysed, vagotomized and ventilated rats, whose age varied from the day of birth to 22 days. 2. The rostral pontine tegmentum was ablated by aspiration and electrolytic lesions. Neuronal activities were blocked by microinjections of the glutamate antagonist MK-801 and were destroyed by the neurotoxins kainic acid and domoic acid. 3. Unilateral ablation or lesions of the pontine tegmentum caused a significant prolongation of the duration of the phrenic burst in animals of all ages. This duration increased further following contralateral destruction and apneusis was established. The period between phrenic bursts increased in most rats whereas peak phrenic height was not consistently altered. 4. Similar changes to those following physical ablations or lesions were recorded after microinjections of MK-801 or neurotoxins. 5. A common region of ablation, lesion and microinjection was the parabrachialis and Kollicker-Fuse nucleus. 6. Exposure to anoxia resulted in an alteration from apnoeusis to gasping. 7. We conclude that from the day of birth, rostral pontine pneumotaxic mechanisms play a significant role in the definition of eupnoea. Moreover, from the day of birth, rats can exhibit the classical ventilatory patterns of eupnoea, apneusis and gasping.
Persistent Identifierhttp://hdl.handle.net/10722/171624
ISSN
2015 Impact Factor: 4.731
2015 SCImago Journal Rankings: 2.670
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:16:01Z-
dc.date.available2012-10-30T06:16:01Z-
dc.date.issued1995en_US
dc.identifier.citationJournal Of Physiology, 1995, v. 489 n. 2, p. 579-591en_US
dc.identifier.issn0022-3751en_US
dc.identifier.urihttp://hdl.handle.net/10722/171624-
dc.description.abstract1. Our purpose was to determine whether a pneumotaxic centre could be localized to the rostral. pens in newborn rats. We recorded efferent activity of the phrenic nerve in decerebrate, paralysed, vagotomized and ventilated rats, whose age varied from the day of birth to 22 days. 2. The rostral pontine tegmentum was ablated by aspiration and electrolytic lesions. Neuronal activities were blocked by microinjections of the glutamate antagonist MK-801 and were destroyed by the neurotoxins kainic acid and domoic acid. 3. Unilateral ablation or lesions of the pontine tegmentum caused a significant prolongation of the duration of the phrenic burst in animals of all ages. This duration increased further following contralateral destruction and apneusis was established. The period between phrenic bursts increased in most rats whereas peak phrenic height was not consistently altered. 4. Similar changes to those following physical ablations or lesions were recorded after microinjections of MK-801 or neurotoxins. 5. A common region of ablation, lesion and microinjection was the parabrachialis and Kollicker-Fuse nucleus. 6. Exposure to anoxia resulted in an alteration from apnoeusis to gasping. 7. We conclude that from the day of birth, rostral pontine pneumotaxic mechanisms play a significant role in the definition of eupnoea. Moreover, from the day of birth, rats can exhibit the classical ventilatory patterns of eupnoea, apneusis and gasping.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_US
dc.relation.ispartofJournal of Physiologyen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshDecerebrate State - Physiopathologyen_US
dc.subject.meshEfferent Pathways - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshInhalation - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhrenic Nerve - Physiologyen_US
dc.subject.meshPons - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRespiration - Physiologyen_US
dc.titleThe functional expression of a pontine pneumotaxic centre in neonatal ratsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8847649-
dc.identifier.scopuseid_2-s2.0-0029565866en_US
dc.identifier.volume489en_US
dc.identifier.issue2en_US
dc.identifier.spage579en_US
dc.identifier.epage591en_US
dc.identifier.isiWOS:A1995TM78100024-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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