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Article: Separation of multiple functions in ventilatory control of pneumotaxic mechanisms

TitleSeparation of multiple functions in ventilatory control of pneumotaxic mechanisms
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1994, v. 96 n. 1, p. 83-98 How to Cite?
AbstractMultiple functions have been ascribed to the pontile pneumotaxic center. We hypothesized that these functions might be separable among neurons in different regions. In decerebrate, vagotomized, paralyzed and ventilated cats, activities of the phrenic and triangularis sterni nerves were recorded. Microinjections of kainic acid were used to destroy neurons. Neurons in the rostrolateral tegmentum at the ponto-mesencephalic border controlled the duration of neural inspiration. Expiratory duration was controlled by neurons in the more caudal nucleus parabrachialis medialis and Kolliker-Fuse nucleus. Ventilatory responses to hypercapnia were depressed following injections of kainic acid into regions controlling either inspiratory or expiratory durations. The phases of expiration were regulated by two groups of neurons, located medial and lateral in the rostral pons. We conclude that rostral pontile and mesencephalic mechanisms control multiple aspects of the eupneic ventilatory cycle. There mechanisms are served by neurons in separable anatomical regions.
Persistent Identifierhttp://hdl.handle.net/10722/171610
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:15:57Z-
dc.date.available2012-10-30T06:15:57Z-
dc.date.issued1994en_US
dc.identifier.citationRespiration Physiology, 1994, v. 96 n. 1, p. 83-98en_US
dc.identifier.issn0034-5687en_US
dc.identifier.urihttp://hdl.handle.net/10722/171610-
dc.description.abstractMultiple functions have been ascribed to the pontile pneumotaxic center. We hypothesized that these functions might be separable among neurons in different regions. In decerebrate, vagotomized, paralyzed and ventilated cats, activities of the phrenic and triangularis sterni nerves were recorded. Microinjections of kainic acid were used to destroy neurons. Neurons in the rostrolateral tegmentum at the ponto-mesencephalic border controlled the duration of neural inspiration. Expiratory duration was controlled by neurons in the more caudal nucleus parabrachialis medialis and Kolliker-Fuse nucleus. Ventilatory responses to hypercapnia were depressed following injections of kainic acid into regions controlling either inspiratory or expiratory durations. The phases of expiration were regulated by two groups of neurons, located medial and lateral in the rostral pons. We conclude that rostral pontile and mesencephalic mechanisms control multiple aspects of the eupneic ventilatory cycle. There mechanisms are served by neurons in separable anatomical regions.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_US
dc.relation.ispartofRespiration Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Stem - Physiologyen_US
dc.subject.meshCatsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHypercapnia - Physiopathologyen_US
dc.subject.meshKainic Acid - Administration & Dosage - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMesencephalon - Physiologyen_US
dc.subject.meshMicroinjectionsen_US
dc.subject.meshNeurons - Physiologyen_US
dc.subject.meshPhrenic Nerve - Physiologyen_US
dc.subject.meshPons - Physiologyen_US
dc.subject.meshRespiration - Physiologyen_US
dc.titleSeparation of multiple functions in ventilatory control of pneumotaxic mechanismsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0034-5687(94)90108-2en_US
dc.identifier.pmid8023023-
dc.identifier.scopuseid_2-s2.0-0028325234en_US
dc.identifier.volume96en_US
dc.identifier.issue1en_US
dc.identifier.spage83en_US
dc.identifier.epage98en_US
dc.identifier.isiWOS:A1994ND37200008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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