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- Publisher Website: 10.1016/0304-3940(94)90175-9
- Scopus: eid_2-s2.0-0028304211
- PMID: 7936407
- WOS: WOS:A1994PF44800040
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Article: Differential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen
Title | Differential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen |
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Authors | |
Keywords | Down-regulation G protein melatonin receptor subtypes Guanine nucleotide Immune system Pineal gland |
Issue Date | 1994 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 1994, v. 173 n. 1-2, p. 167-171 How to Cite? |
Abstract | Effects of 10 and 50 μmol/l guanosine 5'-0-(3-thiotriphosphate) (GTPγS) on 2-[125I]iodomelatonin binding in the chicken bursa of Fabricius and spleen were tested. In the chicken bursa of Fabricius, GTPγS increased the K(d) of 2-[125]iodomelatonin binding sites without affecting the B(max) value. In contrast, GTPγS caused both an increase in K(d) and a reduction in B(max) of 2-[125I]iodomelatonin binding sites in the chicken spleen. Our results suggest the existence of subtypes of melatonin receptors with different receptor-G protein-effector complexes in the avian primary and secondary lymphoid systems. |
Persistent Identifier | http://hdl.handle.net/10722/171609 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Poon, AMS | en_US |
dc.contributor.author | Pang, SF | en_US |
dc.date.accessioned | 2012-10-30T06:15:57Z | - |
dc.date.available | 2012-10-30T06:15:57Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Neuroscience Letters, 1994, v. 173 n. 1-2, p. 167-171 | en_US |
dc.identifier.issn | 0304-3940 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171609 | - |
dc.description.abstract | Effects of 10 and 50 μmol/l guanosine 5'-0-(3-thiotriphosphate) (GTPγS) on 2-[125I]iodomelatonin binding in the chicken bursa of Fabricius and spleen were tested. In the chicken bursa of Fabricius, GTPγS increased the K(d) of 2-[125]iodomelatonin binding sites without affecting the B(max) value. In contrast, GTPγS caused both an increase in K(d) and a reduction in B(max) of 2-[125I]iodomelatonin binding sites in the chicken spleen. Our results suggest the existence of subtypes of melatonin receptors with different receptor-G protein-effector complexes in the avian primary and secondary lymphoid systems. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_US |
dc.relation.ispartof | Neuroscience Letters | en_US |
dc.rights | Neuroscience Letters. Copyright © Elsevier Ireland Ltd. | - |
dc.subject | Down-regulation | - |
dc.subject | G protein melatonin receptor subtypes | - |
dc.subject | Guanine nucleotide | - |
dc.subject | Immune system | - |
dc.subject | Pineal gland | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bursa Of Fabricius - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Chickens | en_US |
dc.subject.mesh | Down-Regulation - Drug Effects | en_US |
dc.subject.mesh | Guanosine 5'-O-(3-Thiotriphosphate) - Pharmacology | en_US |
dc.subject.mesh | Guanosine Triphosphate - Pharmacology | en_US |
dc.subject.mesh | Iodine Radioisotopes - Diagnostic Use | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Melatonin - Metabolism | en_US |
dc.subject.mesh | Membranes - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Receptors, Cell Surface - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Receptors, Melatonin | en_US |
dc.subject.mesh | Spleen - Drug Effects - Metabolism | en_US |
dc.title | Differential effects of guanosine 5'-O-(3-thiotriphosphate) (GTPγS) on the 2-[125I]iodomelatonin binding sites in the chicken bursa of Fabricius and spleen | en_US |
dc.type | Article | en_US |
dc.identifier.email | Poon, AMS:amspoon@hkucc.hku.hk | en_US |
dc.identifier.email | Pang, SF: hrmypsf@hkucc.hku.hk | - |
dc.identifier.authority | Poon, AMS=rp00354 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0304-3940(94)90175-9 | en_US |
dc.identifier.pmid | 7936407 | - |
dc.identifier.scopus | eid_2-s2.0-0028304211 | en_US |
dc.identifier.hkuros | 2698 | - |
dc.identifier.volume | 173 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 167 | en_US |
dc.identifier.epage | 171 | en_US |
dc.identifier.isi | WOS:A1994PF44800040 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Poon, AMS=7103068868 | en_US |
dc.identifier.scopusauthorid | Pang, SF=7402528719 | en_US |
dc.identifier.issnl | 0304-3940 | - |