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Article: Mechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogs

TitleMechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogs
Authors
Issue Date1994
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 1994, v. 112 n. 2, p. 411-416 How to Cite?
AbstractThe effects of superimposed and continuous sympathetic nerve stimulation on submandibular parasympathetic salivation were investigated in anaesthetized dogs. Superimposed sympathetic nerve stimulation (1-2 min) initially enhanced and later inhibited salivary secretion induced by parasympathetic nerve stimulation (2-8 Hz) in glands with uncontrolled blood supply or constant-flow vascular perfusion. Propranolol 0.005 mg kg-1, i.a.) did not affect the diphasic sympathetic action whereas phentolamine (0.1 mg kg-1, i.a.) abolished it. Prazosin (0.025 mg kg-1, i.a.) greatly lessened the initial enhancement while yohimbine (0.025 mg kg-1, i.a.) alleviated the late inhibition. Salivary secretion, induced by parasympathetic nerve stimulation (4 Hz) or acetylcholine infusion (10 μg kg-1 min-1, i.a.), was abolished by atropine (0.05 mg kg-1, i.a.), increased by phenylephrine infusion (0.25 μg kg-1 min-1, i.a.) and depressed by clonidine infusion (0.75 μg kg-1 min-1, i.a.). Hexamethionium (12.5 mg kg-1, i.a.) abolished the nerve-induced secretion but had no effect on the acetylcholine-induced secretion. Continuous background sympathetic nerve stimulation decreased parasympathetic nerve-induced salivary secretion in glands with uncontrolled blood supply or constant-flow vascular perfusion. These results show that parasympathetic salivation can be modified by the sympathetic system at the postsynaptic level; enhancement is via α1-adrenoceptors whereas inhibition is via a2-adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/171607
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.date.accessioned2012-10-30T06:15:56Z-
dc.date.available2012-10-30T06:15:56Z-
dc.date.issued1994en_US
dc.identifier.citationBritish Journal Of Pharmacology, 1994, v. 112 n. 2, p. 411-416en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/171607-
dc.description.abstractThe effects of superimposed and continuous sympathetic nerve stimulation on submandibular parasympathetic salivation were investigated in anaesthetized dogs. Superimposed sympathetic nerve stimulation (1-2 min) initially enhanced and later inhibited salivary secretion induced by parasympathetic nerve stimulation (2-8 Hz) in glands with uncontrolled blood supply or constant-flow vascular perfusion. Propranolol 0.005 mg kg-1, i.a.) did not affect the diphasic sympathetic action whereas phentolamine (0.1 mg kg-1, i.a.) abolished it. Prazosin (0.025 mg kg-1, i.a.) greatly lessened the initial enhancement while yohimbine (0.025 mg kg-1, i.a.) alleviated the late inhibition. Salivary secretion, induced by parasympathetic nerve stimulation (4 Hz) or acetylcholine infusion (10 μg kg-1 min-1, i.a.), was abolished by atropine (0.05 mg kg-1, i.a.), increased by phenylephrine infusion (0.25 μg kg-1 min-1, i.a.) and depressed by clonidine infusion (0.75 μg kg-1 min-1, i.a.). Hexamethionium (12.5 mg kg-1, i.a.) abolished the nerve-induced secretion but had no effect on the acetylcholine-induced secretion. Continuous background sympathetic nerve stimulation decreased parasympathetic nerve-induced salivary secretion in glands with uncontrolled blood supply or constant-flow vascular perfusion. These results show that parasympathetic salivation can be modified by the sympathetic system at the postsynaptic level; enhancement is via α1-adrenoceptors whereas inhibition is via a2-adrenoceptors.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-1 Receptor Antagonistsen_US
dc.subject.meshAdrenergic Alpha-2 Receptor Antagonistsen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshParasympathetic Nervous System - Drug Effects - Physiologyen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.subject.meshSalivation - Drug Effects - Physiologyen_US
dc.subject.meshSubmandibular Gland - Blood Supply - Drug Effects - Secretionen_US
dc.subject.meshSympathetic Nervous System - Drug Effects - Physiologyen_US
dc.titleMechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogsen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1476-5381.1994.tb13087.x-
dc.identifier.pmid8075858-
dc.identifier.scopuseid_2-s2.0-0028275527en_US
dc.identifier.volume112en_US
dc.identifier.issue2en_US
dc.identifier.spage411en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:A1994NN63600013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US

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