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Article: Electrical stimulation of pneumotaxic center: Activation of fibers and neurons

TitleElectrical stimulation of pneumotaxic center: Activation of fibers and neurons
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1994, v. 96 n. 1, p. 71-82 How to Cite?
AbstractElectrical stimulations of the pneumotaxic center can result in a phase-switch from neural inspiration to expiration or the reverse. Terminations of inspiration are also obtained from many loci ventral to the pneumotaxic center. We hypothesized that responses to some stimulations reflect an activation of fibers rather than neurons. Studies were conducted in decerebrate, vagotomized, paralyzed and ventilated cats. Activities of the phrenic and triangularis sterni nerves were recorded. A multibarreled pipette was inserted into the rostral pons. Electrical stimulation was delivered through two barrels; another contained kainic acid to destroy neurons. The threshold current for producing inspiratory termination was not altered in most regions following the injections of kainic acid. However, stimulation of neurons did appear to underlie the premature onset of phrenic activity. In addition, neurons in medial pontile regions regulate triangularis sterni activity. We conclude that some functions ascribed to the pneumotaxic center are, in fact, subserved by neurons in other regions of the central nervous system.
Persistent Identifierhttp://hdl.handle.net/10722/171606
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:15:56Z-
dc.date.available2012-10-30T06:15:56Z-
dc.date.issued1994en_US
dc.identifier.citationRespiration Physiology, 1994, v. 96 n. 1, p. 71-82en_US
dc.identifier.issn0034-5687en_US
dc.identifier.urihttp://hdl.handle.net/10722/171606-
dc.description.abstractElectrical stimulations of the pneumotaxic center can result in a phase-switch from neural inspiration to expiration or the reverse. Terminations of inspiration are also obtained from many loci ventral to the pneumotaxic center. We hypothesized that responses to some stimulations reflect an activation of fibers rather than neurons. Studies were conducted in decerebrate, vagotomized, paralyzed and ventilated cats. Activities of the phrenic and triangularis sterni nerves were recorded. A multibarreled pipette was inserted into the rostral pons. Electrical stimulation was delivered through two barrels; another contained kainic acid to destroy neurons. The threshold current for producing inspiratory termination was not altered in most regions following the injections of kainic acid. However, stimulation of neurons did appear to underlie the premature onset of phrenic activity. In addition, neurons in medial pontile regions regulate triangularis sterni activity. We conclude that some functions ascribed to the pneumotaxic center are, in fact, subserved by neurons in other regions of the central nervous system.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_US
dc.relation.ispartofRespiration Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshKainic Acid - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMedulla Oblongata - Physiologyen_US
dc.subject.meshMicroinjectionsen_US
dc.subject.meshNerve Fibers - Physiologyen_US
dc.subject.meshNeurons - Physiologyen_US
dc.subject.meshPhrenic Nerve - Physiologyen_US
dc.subject.meshPons - Physiologyen_US
dc.subject.meshRespiration - Drug Effects - Physiologyen_US
dc.titleElectrical stimulation of pneumotaxic center: Activation of fibers and neuronsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0034-5687(94)90107-4en_US
dc.identifier.pmid8023022-
dc.identifier.scopuseid_2-s2.0-0028205161en_US
dc.identifier.volume96en_US
dc.identifier.issue1en_US
dc.identifier.spage71en_US
dc.identifier.epage82en_US
dc.identifier.isiWOS:A1994ND37200007-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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