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Article: Neuronal activities underlying inspiratory termination by pneumotaxic mechanisms

TitleNeuronal activities underlying inspiratory termination by pneumotaxic mechanisms
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1994, v. 98 n. 3, p. 267-281 How to Cite?
AbstractThe purpose was to identify and characterize the discharge patterns of pontile neurons which are responsible for the termination of inspiratory activity. Phrenic discharge is prolonged following destruction of neurons at the junction of mesencephalon and pons by neurotoxins. Neuronal activities were recorded in this region in decerebrate, vagotomized, paralyzed and ventilated cats. At normocapnia, neurons had tonic discharge patterns, most of which were linked to phasic periods of phrenic activity. Peak activities occurred in late neural inspiration or early expiration. In hypercapnia, neuronal discharge frequencies did not increase, rather activity became more concentrated during one portion of the respiratory cycle. In severe hypoxia, neuronal activities diminished in parallel with the prolongations of phrenic discharge and establishment of apneusis. During recovery, some neurons transiently acquired phasic, respiratory-modulated discharge patterns. Neuronal activities from neighboring regions did not exhibit comparable changes in hypercapnia or hypoxia. We conclude that rostral pontile neuronal activities are a primary determinant of the reversible and irreversible terminations of eupneic inspiratory activity.
Persistent Identifierhttp://hdl.handle.net/10722/171604
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:15:56Z-
dc.date.available2012-10-30T06:15:56Z-
dc.date.issued1994en_US
dc.identifier.citationRespiration Physiology, 1994, v. 98 n. 3, p. 267-281en_US
dc.identifier.issn0034-5687en_US
dc.identifier.urihttp://hdl.handle.net/10722/171604-
dc.description.abstractThe purpose was to identify and characterize the discharge patterns of pontile neurons which are responsible for the termination of inspiratory activity. Phrenic discharge is prolonged following destruction of neurons at the junction of mesencephalon and pons by neurotoxins. Neuronal activities were recorded in this region in decerebrate, vagotomized, paralyzed and ventilated cats. At normocapnia, neurons had tonic discharge patterns, most of which were linked to phasic periods of phrenic activity. Peak activities occurred in late neural inspiration or early expiration. In hypercapnia, neuronal discharge frequencies did not increase, rather activity became more concentrated during one portion of the respiratory cycle. In severe hypoxia, neuronal activities diminished in parallel with the prolongations of phrenic discharge and establishment of apneusis. During recovery, some neurons transiently acquired phasic, respiratory-modulated discharge patterns. Neuronal activities from neighboring regions did not exhibit comparable changes in hypercapnia or hypoxia. We conclude that rostral pontile neuronal activities are a primary determinant of the reversible and irreversible terminations of eupneic inspiratory activity.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_US
dc.relation.ispartofRespiration Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshCarbon Monoxide - Toxicityen_US
dc.subject.meshCatsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHypercapnia - Physiopathologyen_US
dc.subject.meshKainic Acid - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMesencephalon - Physiologyen_US
dc.subject.meshNeurons - Drug Effects - Physiologyen_US
dc.subject.meshPhrenic Nerve - Drug Effects - Physiologyen_US
dc.subject.meshPons - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshRespiration - Drug Effects - Physiologyen_US
dc.titleNeuronal activities underlying inspiratory termination by pneumotaxic mechanismsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0034-5687(94)90076-0en_US
dc.identifier.pmid7899728-
dc.identifier.scopuseid_2-s2.0-0028138999en_US
dc.identifier.volume98en_US
dc.identifier.issue3en_US
dc.identifier.spage267en_US
dc.identifier.epage281en_US
dc.identifier.isiWOS:A1994PU81700003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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