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Article: Increase or decrease in nasal airway resistance induced by acetylcholine in anesthetized dogs: Vascular mechanisms

TitleIncrease or decrease in nasal airway resistance induced by acetylcholine in anesthetized dogs: Vascular mechanisms
Authors
Issue Date1994
PublisherAnnals Publishing Co. The Journal's web site is located at http://www.annals.com
Citation
Annals Of Otology, Rhinology And Laryngology, 1994, v. 103 n. 8 I, p. 646-651 How to Cite?
AbstractIn sodium pentobarbital-anesthetized dogs with spontaneous nasal blood flow or constant-flow vascular perfusion of the nasal mucosa, we measured nasal airway resistance, vascular resistance, and arterial inflow and outflow of the anterior and posterior venous systems. Acetylcholine in low doses (<5 μg/kg per minute, intraarterially) increased nasal airway resistance, and the response was greater in dogs with spontaneous blood flow. Nasal vascular resistance was decreased. However, the posterior venous outflow was increased and the anterior venous outflow was decreased in dogs with constant-flow vascular perfusion. Acetylcholine in higher doses (>5 μg/kg per minute, intraarterially) decreased nasal airway resistance, and vascular resistance fell further, but both venous outflows were increased in dogs with spontaneous blood flow or constant-flow vascular perfusion. The results indicate that acetylcholine may increase or decrease nasal airway resistance, depending on the dose administered, probably via a dose-dependent differential action on different components of the nasal vascular bed.
Persistent Identifierhttp://hdl.handle.net/10722/171603
ISSN
2015 Impact Factor: 1.171
2015 SCImago Journal Rankings: 0.727
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.contributor.authorWang, JCCen_US
dc.date.accessioned2012-10-30T06:15:55Z-
dc.date.available2012-10-30T06:15:55Z-
dc.date.issued1994en_US
dc.identifier.citationAnnals Of Otology, Rhinology And Laryngology, 1994, v. 103 n. 8 I, p. 646-651en_US
dc.identifier.issn0003-4894en_US
dc.identifier.urihttp://hdl.handle.net/10722/171603-
dc.description.abstractIn sodium pentobarbital-anesthetized dogs with spontaneous nasal blood flow or constant-flow vascular perfusion of the nasal mucosa, we measured nasal airway resistance, vascular resistance, and arterial inflow and outflow of the anterior and posterior venous systems. Acetylcholine in low doses (<5 μg/kg per minute, intraarterially) increased nasal airway resistance, and the response was greater in dogs with spontaneous blood flow. Nasal vascular resistance was decreased. However, the posterior venous outflow was increased and the anterior venous outflow was decreased in dogs with constant-flow vascular perfusion. Acetylcholine in higher doses (>5 μg/kg per minute, intraarterially) decreased nasal airway resistance, and vascular resistance fell further, but both venous outflows were increased in dogs with spontaneous blood flow or constant-flow vascular perfusion. The results indicate that acetylcholine may increase or decrease nasal airway resistance, depending on the dose administered, probably via a dose-dependent differential action on different components of the nasal vascular bed.en_US
dc.languageengen_US
dc.publisherAnnals Publishing Co. The Journal's web site is located at http://www.annals.comen_US
dc.relation.ispartofAnnals of Otology, Rhinology and Laryngologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAirway Resistance - Drug Effects - Physiologyen_US
dc.subject.meshAnesthesia, Intravenousen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshNasal Mucosa - Blood Supplyen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleIncrease or decrease in nasal airway resistance induced by acetylcholine in anesthetized dogs: Vascular mechanismsen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/000348949410300812-
dc.identifier.pmid8060060-
dc.identifier.scopuseid_2-s2.0-0028129765en_US
dc.identifier.hkuros3180-
dc.identifier.volume103en_US
dc.identifier.issue8 Ien_US
dc.identifier.spage646en_US
dc.identifier.epage651en_US
dc.identifier.isiWOS:A1994PC15300012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US
dc.identifier.scopusauthoridWang, JCC=7701314571en_US

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