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Article: Cross talk between plasma membrane and sarcoplasmic reticulum in canine airway smooth muscle

TitleCross talk between plasma membrane and sarcoplasmic reticulum in canine airway smooth muscle
Authors
Issue Date1993
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
Biological Signals, 1993, v. 2 n. 5, p. 272-283 How to Cite?
AbstractIn smooth muscle, contractions under pharmacomechanical and electromechanical coupling mechanism control rely on mobilization of intracellular calcium and on calcium influx from the extracellular space, respectively. In airway smooth muscle, pharmacomechanical coupling seems to predominate. Even if extracellular calcium enters the cell during agonist stimulation, and contributes to the maintained plateau phase of a prolonged stimulation-induced contraction, it does not result from membrane depolarization and is not part of the electromechanical coupling mechanism. Pharmacomechanical and electromechanical coupling are most likely not independent processes: we present here an example of cross talk between plasma membrane and sarcoplasmic reticulum, which results in an almost complete switch in the E-C coupling process from pharmaco- to electromechanical mode in tracheal smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/171599
ISSN

 

DC FieldValueLanguage
dc.contributor.authorBourreau, JPen_US
dc.date.accessioned2012-10-30T06:15:55Z-
dc.date.available2012-10-30T06:15:55Z-
dc.date.issued1993en_US
dc.identifier.citationBiological Signals, 1993, v. 2 n. 5, p. 272-283en_US
dc.identifier.issn1016-0922en_US
dc.identifier.urihttp://hdl.handle.net/10722/171599-
dc.description.abstractIn smooth muscle, contractions under pharmacomechanical and electromechanical coupling mechanism control rely on mobilization of intracellular calcium and on calcium influx from the extracellular space, respectively. In airway smooth muscle, pharmacomechanical coupling seems to predominate. Even if extracellular calcium enters the cell during agonist stimulation, and contributes to the maintained plateau phase of a prolonged stimulation-induced contraction, it does not result from membrane depolarization and is not part of the electromechanical coupling mechanism. Pharmacomechanical and electromechanical coupling are most likely not independent processes: we present here an example of cross talk between plasma membrane and sarcoplasmic reticulum, which results in an almost complete switch in the E-C coupling process from pharmaco- to electromechanical mode in tracheal smooth muscle.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_US
dc.relation.ispartofBiological Signalsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCalcium Channels - Physiologyen_US
dc.subject.meshCell Membrane - Metabolism - Physiologyen_US
dc.subject.meshDogs - Physiologyen_US
dc.subject.meshMuscle, Smooth - Physiologyen_US
dc.subject.meshRoc Curveen_US
dc.subject.meshRespiratory Physiological Phenomenaen_US
dc.subject.meshSarcoplasmic Reticulum - Physiologyen_US
dc.subject.meshSecond Messenger Systemsen_US
dc.titleCross talk between plasma membrane and sarcoplasmic reticulum in canine airway smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailBourreau, JP:bourreau@hkucc.hku.hken_US
dc.identifier.authorityBourreau, JP=rp00389en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8038859-
dc.identifier.scopuseid_2-s2.0-0027851313en_US
dc.identifier.volume2en_US
dc.identifier.issue5en_US
dc.identifier.spage272en_US
dc.identifier.epage283en_US
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridBourreau, JP=7003927886en_US

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