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- Publisher Website: 10.1006/bbrc.1993.2416
- Scopus: eid_2-s2.0-0027497231
- PMID: 8250903
- WOS: WOS:A1993MG31000064
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Article: A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes
Title | A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes |
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Authors | |
Issue Date | 1993 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical And Biophysical Research Communications, 1993, v. 196 n. 3, p. 1459-1465 How to Cite? |
Abstract | The three ectoenzyme activities, NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase were purified to homogeneity from solubilized human erythrocyte membranes. The purification procedure involved three sequential chromatography steps on hydroxylapatite, immobilized Cu++ and immobilized anti-CD38 monoclonal antibody resins. The final step yielded a single 46 kDa protein displaying all three enzymatic activities. Since the protein bound specifically to the anti-CD38 resin, it was immunologically identified as CD38, a 46 kDa surface antigen involved in activation and proliferation of lymphocyte populations. |
Persistent Identifier | http://hdl.handle.net/10722/171592 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zocchi, E | en_US |
dc.contributor.author | Franco, L | en_US |
dc.contributor.author | Guida, L | en_US |
dc.contributor.author | Benatti, U | en_US |
dc.contributor.author | Bargellesi, A | en_US |
dc.contributor.author | Malavasi, F | en_US |
dc.contributor.author | Lee, HC | en_US |
dc.contributor.author | De Flora, A | en_US |
dc.date.accessioned | 2012-10-30T06:15:52Z | - |
dc.date.available | 2012-10-30T06:15:52Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Biochemical And Biophysical Research Communications, 1993, v. 196 n. 3, p. 1459-1465 | en_US |
dc.identifier.issn | 0006-291X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171592 | - |
dc.description.abstract | The three ectoenzyme activities, NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase were purified to homogeneity from solubilized human erythrocyte membranes. The purification procedure involved three sequential chromatography steps on hydroxylapatite, immobilized Cu++ and immobilized anti-CD38 monoclonal antibody resins. The final step yielded a single 46 kDa protein displaying all three enzymatic activities. Since the protein bound specifically to the anti-CD38 resin, it was immunologically identified as CD38, a 46 kDa surface antigen involved in activation and proliferation of lymphocyte populations. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | en_US |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | en_US |
dc.subject.mesh | Adp-Ribosyl Cyclase | en_US |
dc.subject.mesh | Antigens, Cd - Blood - Isolation & Purification | en_US |
dc.subject.mesh | Antigens, Cd38 | en_US |
dc.subject.mesh | Antigens, Differentiation - Blood - Isolation & Purification | en_US |
dc.subject.mesh | Chlorides - Pharmacology | en_US |
dc.subject.mesh | Chromatography | en_US |
dc.subject.mesh | Copper - Pharmacology | en_US |
dc.subject.mesh | Durapatite | en_US |
dc.subject.mesh | Electrophoresis, Polyacrylamide Gel | en_US |
dc.subject.mesh | Erythrocyte Membrane - Enzymology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Membrane Glycoproteins | en_US |
dc.subject.mesh | Molecular Weight | en_US |
dc.subject.mesh | N-Glycosyl Hydrolases - Blood - Isolation & Purification | en_US |
dc.subject.mesh | Nad+ Nucleosidase - Blood - Isolation & Purification | en_US |
dc.subject.mesh | Zinc Compounds - Pharmacology | en_US |
dc.title | A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
dc.identifier.authority | Lee, HC=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1006/bbrc.1993.2416 | en_US |
dc.identifier.pmid | 8250903 | - |
dc.identifier.scopus | eid_2-s2.0-0027497231 | en_US |
dc.identifier.volume | 196 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 1459 | en_US |
dc.identifier.epage | 1465 | en_US |
dc.identifier.isi | WOS:A1993MG31000064 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zocchi, E=7003441674 | en_US |
dc.identifier.scopusauthorid | Franco, L=35412467500 | en_US |
dc.identifier.scopusauthorid | Guida, L=7006059917 | en_US |
dc.identifier.scopusauthorid | Benatti, U=7005696019 | en_US |
dc.identifier.scopusauthorid | Bargellesi, A=7003422297 | en_US |
dc.identifier.scopusauthorid | Malavasi, F=7004453948 | en_US |
dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
dc.identifier.scopusauthorid | De Flora, A=7006450815 | en_US |
dc.identifier.issnl | 0006-291X | - |