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Article: Age-related changes in the contents of neuropeptides in the rat brain and pituitary

TitleAge-related changes in the contents of neuropeptides in the rat brain and pituitary
Authors
Issue Date1993
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging
Citation
Neurobiology Of Aging, 1993, v. 14 n. 6, p. 529-534 How to Cite?
Abstractβ-Endorphin, Leu-enkephalin, Met-enkephalin, substance P, somatostatin, and cholecystokinin were measured in the brain and the pituitary of male Sprague-Dawley rats aged 3 months, 12 months, and 22 months. β-Endorphin, Met-enkephalin and Len-enkephalin contents in the neurointermediate lobe, and the enkephalin levels in the anterior lobe of the pituitary increased with age. The increases in contents were both in the day and at night for β-endorphin and Met-enkephalin. However, the increase for Leu-enkephalin content was in the day only. Hypothalamic β-endorphin content decreased with age only in the day. β-Endorphin and Leu-enkephalin contents in the brain stem, and Leu-enkephalin levels contents in the cortex decreased with age at night. Leu-enkephalin in the striatum decreased with age in the day. There was also an age-related decrease for somatostatin and substance P contents in the striatum and the hypothalamus in the day, and in cholecystokinin levels in the hippocampus, and the hypothalamus at night. It is concluded that there are age differences in neuropeptide levels, and that these changes may differ according to diurnal rhythms.
Persistent Identifierhttp://hdl.handle.net/10722/171591
ISSN
2015 Impact Factor: 5.153
2015 SCImago Journal Rankings: 2.613
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, ZPen_US
dc.contributor.authorMan, SYen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:15:52Z-
dc.date.available2012-10-30T06:15:52Z-
dc.date.issued1993en_US
dc.identifier.citationNeurobiology Of Aging, 1993, v. 14 n. 6, p. 529-534en_US
dc.identifier.issn0197-4580en_US
dc.identifier.urihttp://hdl.handle.net/10722/171591-
dc.description.abstractβ-Endorphin, Leu-enkephalin, Met-enkephalin, substance P, somatostatin, and cholecystokinin were measured in the brain and the pituitary of male Sprague-Dawley rats aged 3 months, 12 months, and 22 months. β-Endorphin, Met-enkephalin and Len-enkephalin contents in the neurointermediate lobe, and the enkephalin levels in the anterior lobe of the pituitary increased with age. The increases in contents were both in the day and at night for β-endorphin and Met-enkephalin. However, the increase for Leu-enkephalin content was in the day only. Hypothalamic β-endorphin content decreased with age only in the day. β-Endorphin and Leu-enkephalin contents in the brain stem, and Leu-enkephalin levels contents in the cortex decreased with age at night. Leu-enkephalin in the striatum decreased with age in the day. There was also an age-related decrease for somatostatin and substance P contents in the striatum and the hypothalamus in the day, and in cholecystokinin levels in the hippocampus, and the hypothalamus at night. It is concluded that there are age differences in neuropeptide levels, and that these changes may differ according to diurnal rhythms.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuagingen_US
dc.relation.ispartofNeurobiology of Agingen_US
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Growth & Developmenten_US
dc.subject.meshBrain Chemistry - Physiologyen_US
dc.subject.meshCircadian Rhythm - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuropeptides - Metabolismen_US
dc.subject.meshPituitary Gland - Growth & Development - Metabolismen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleAge-related changes in the contents of neuropeptides in the rat brain and pituitaryen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0197-4580(93)90035-Aen_US
dc.identifier.pmid8295655-
dc.identifier.scopuseid_2-s2.0-0027484883en_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.spage529en_US
dc.identifier.epage534en_US
dc.identifier.isiWOS:A1993MH15800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, ZP=7410040853en_US
dc.identifier.scopusauthoridMan, SY=7103398069en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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