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Article: Effect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid rat

TitleEffect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid rat
Authors
Issue Date1993
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1993, v. 20 n. 1, p. 65-70 How to Cite?
Abstract1. Fourteen days after hypothyroidism was induced either by propylthiouracil (PTU) treatment or by thyroidectomy, the serum thyrotropin (TSH) responses to morphine (5 or 20 mg/kg bw), ether stress (30 min) and cold exposure (60 min) were compared with those in normal rats. 2. The decrease in serum TSH levels after morphine and ether stress found in the normal rats were abolished or much reduced respectively. 3. The increase in serum TSH in response to cold exposure and the diurnal rhythm of serum TSH (lower level at night) were also absent in the hypothyroid rat. 4. The stimulating effects of low dose of thyrotropin relasing hormone (TRH) and the inhibitory effects of somatostatin and apomorphine were completely abolished, while the stimulating effects of a high dose of TRH were much reduced in the hypothyroid rat. 5. These results indicate that in the hypothyroid rat the effect of a lack of negative feedback action of thyroid hormone predominates, and that hypothalamic factors are probably unimportant in the regulation of TSH secretion.
Persistent Identifierhttp://hdl.handle.net/10722/171590
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDou, YLen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:15:51Z-
dc.date.available2012-10-30T06:15:51Z-
dc.date.issued1993en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1993, v. 20 n. 1, p. 65-70en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171590-
dc.description.abstract1. Fourteen days after hypothyroidism was induced either by propylthiouracil (PTU) treatment or by thyroidectomy, the serum thyrotropin (TSH) responses to morphine (5 or 20 mg/kg bw), ether stress (30 min) and cold exposure (60 min) were compared with those in normal rats. 2. The decrease in serum TSH levels after morphine and ether stress found in the normal rats were abolished or much reduced respectively. 3. The increase in serum TSH in response to cold exposure and the diurnal rhythm of serum TSH (lower level at night) were also absent in the hypothyroid rat. 4. The stimulating effects of low dose of thyrotropin relasing hormone (TRH) and the inhibitory effects of somatostatin and apomorphine were completely abolished, while the stimulating effects of a high dose of TRH were much reduced in the hypothyroid rat. 5. These results indicate that in the hypothyroid rat the effect of a lack of negative feedback action of thyroid hormone predominates, and that hypothalamic factors are probably unimportant in the regulation of TSH secretion.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApomorphine - Pharmacologyen_US
dc.subject.meshCircadian Rhythm - Physiologyen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshEther, Ethyl - Adverse Effectsen_US
dc.subject.meshHypothalamic Hormones - Pharmacology - Physiologyen_US
dc.subject.meshHypothyroidism - Blood - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMorphine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSomatostatin - Pharmacologyen_US
dc.subject.meshStress, Physiological - Chemically Induced - Physiopathologyen_US
dc.subject.meshThyrotropin - Blood - Secretionen_US
dc.subject.meshThyrotropin-Releasing Hormone - Pharmacologyen_US
dc.subject.meshThyroxine - Pharmacologyen_US
dc.titleEffect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid raten_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1993.tb01504.x-
dc.identifier.pmid8094328-
dc.identifier.scopuseid_2-s2.0-0027441471en_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.spage65en_US
dc.identifier.epage70en_US
dc.identifier.isiWOS:A1993KG57400010-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridDou, YL=7005659149en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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