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- Publisher Website: 10.1111/j.1440-1681.1993.tb01504.x
- Scopus: eid_2-s2.0-0027441471
- PMID: 8094328
- WOS: WOS:A1993KG57400010
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Article: Effect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid rat
Title | Effect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid rat |
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Authors | |
Keywords | apomorphine cold hypothyroid rat morphine somatostatin stress thyrotropin thyrotropin releasing hormone. |
Issue Date | 1993 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1993, v. 20 n. 1, p. 65-70 How to Cite? |
Abstract | 1. Fourteen days after hypothyroidism was induced either by propylthiouracil (PTU) treatment or by thyroidectomy, the serum thyrotropin (TSH) responses to morphine (5 or 20 mg/kg bw), ether stress (30 min) and cold exposure (60 min) were compared with those in normal rats. 2. The decrease in serum TSH levels after morphine and ether stress found in the normal rats were abolished or much reduced respectively. 3. The increase in serum TSH in response to cold exposure and the diurnal rhythm of serum TSH (lower level at night) were also absent in the hypothyroid rat. 4. The stimulating effects of low dose of thyrotropin relasing hormone (TRH) and the inhibitory effects of somatostatin and apomorphine were completely abolished, while the stimulating effects of a high dose of TRH were much reduced in the hypothyroid rat. 5. These results indicate that in the hypothyroid rat the effect of a lack of negative feedback action of thyroid hormone predominates, and that hypothalamic factors are probably unimportant in the regulation of TSH secretion. |
Persistent Identifier | http://hdl.handle.net/10722/171590 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Dou, YL | en_US |
dc.contributor.author | Tang, F | en_US |
dc.date.accessioned | 2012-10-30T06:15:51Z | - |
dc.date.available | 2012-10-30T06:15:51Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1993, v. 20 n. 1, p. 65-70 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171590 | - |
dc.description.abstract | 1. Fourteen days after hypothyroidism was induced either by propylthiouracil (PTU) treatment or by thyroidectomy, the serum thyrotropin (TSH) responses to morphine (5 or 20 mg/kg bw), ether stress (30 min) and cold exposure (60 min) were compared with those in normal rats. 2. The decrease in serum TSH levels after morphine and ether stress found in the normal rats were abolished or much reduced respectively. 3. The increase in serum TSH in response to cold exposure and the diurnal rhythm of serum TSH (lower level at night) were also absent in the hypothyroid rat. 4. The stimulating effects of low dose of thyrotropin relasing hormone (TRH) and the inhibitory effects of somatostatin and apomorphine were completely abolished, while the stimulating effects of a high dose of TRH were much reduced in the hypothyroid rat. 5. These results indicate that in the hypothyroid rat the effect of a lack of negative feedback action of thyroid hormone predominates, and that hypothalamic factors are probably unimportant in the regulation of TSH secretion. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | apomorphine | - |
dc.subject | cold | - |
dc.subject | hypothyroid rat | - |
dc.subject | morphine | - |
dc.subject | somatostatin | - |
dc.subject | stress | - |
dc.subject | thyrotropin | - |
dc.subject | thyrotropin releasing hormone. | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apomorphine - Pharmacology | en_US |
dc.subject.mesh | Circadian Rhythm - Physiology | en_US |
dc.subject.mesh | Cold Temperature | en_US |
dc.subject.mesh | Environmental Exposure | en_US |
dc.subject.mesh | Ether, Ethyl - Adverse Effects | en_US |
dc.subject.mesh | Hypothalamic Hormones - Pharmacology - Physiology | en_US |
dc.subject.mesh | Hypothyroidism - Blood - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Morphine - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Somatostatin - Pharmacology | en_US |
dc.subject.mesh | Stress, Physiological - Chemically Induced - Physiopathology | en_US |
dc.subject.mesh | Thyrotropin - Blood - Secretion | en_US |
dc.subject.mesh | Thyrotropin-Releasing Hormone - Pharmacology | en_US |
dc.subject.mesh | Thyroxine - Pharmacology | en_US |
dc.title | Effect of environmental and hypothalamic factors on thyrotropin secretion in the hypothyroid rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, F:ftang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, F=rp00327 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1993.tb01504.x | - |
dc.identifier.pmid | 8094328 | - |
dc.identifier.scopus | eid_2-s2.0-0027441471 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 65 | en_US |
dc.identifier.epage | 70 | en_US |
dc.identifier.isi | WOS:A1993KG57400010 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Dou, YL=7005659149 | en_US |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_US |
dc.identifier.issnl | 0305-1870 | - |