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- Scopus: eid_2-s2.0-0027318688
- PMID: 8365984
- WOS: WOS:A1993LL82000028
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Article: Pontile regulation of ventilatory activity in the adult rat
Title | Pontile regulation of ventilatory activity in the adult rat |
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Authors | |
Keywords | apneusis control of respiration eupnea pneumotaxic center vagi |
Issue Date | 1993 |
Citation | Journal Of Applied Physiology, 1993, v. 74 n. 6, p. 2801-2811 How to Cite? |
Abstract | Our purpose was to characterize the pontile components of the brain stem ventilatory control system in rats. This study was precipitated by reports that this pontile component might differ fundamentally from that of other species. Efferent activity of the phrenic nerve was recorded in anesthetized, vagotomized, paralyzed, and ventilated adult rats. As in other species, electrical stimulations of the rostral pons caused premature terminations and/or onsets of phrenic activity in eupnea. Electrolytic lesions of rostrolateral pons resulted in apneusis, characterized by significant prolongations of the phrenic burst. Some effective lesions were in the region of the nucleus parabrachialis medialis and the Kolliker-Fuse nucleus, the site of the pneumotaxic center. Other lesions resulting in apneusis were ventral to the pneumotaxic center. As in cats, lesions in the caudal pontile reticular formation caused the duration of the apneustic neural inspiration to return toward that of eupnea. Again, as in other species, gradual alterations from eupnea to gasping in the rat were recorded during hypoxia, which was induced by ventilation with carbon monoxide. We conclude that the brain stem respiratory control system is similarly organized in rats and other mammalian species. These results have implications for contemporary hypotheses concerning the neurogenesis of ventilatory activity. |
Persistent Identifier | http://hdl.handle.net/10722/171583 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.042 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, W | en_US |
dc.contributor.author | Fung, ML | en_US |
dc.contributor.author | St John, WM | en_US |
dc.date.accessioned | 2012-10-30T06:15:49Z | - |
dc.date.available | 2012-10-30T06:15:49Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Journal Of Applied Physiology, 1993, v. 74 n. 6, p. 2801-2811 | en_US |
dc.identifier.issn | 8750-7587 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171583 | - |
dc.description.abstract | Our purpose was to characterize the pontile components of the brain stem ventilatory control system in rats. This study was precipitated by reports that this pontile component might differ fundamentally from that of other species. Efferent activity of the phrenic nerve was recorded in anesthetized, vagotomized, paralyzed, and ventilated adult rats. As in other species, electrical stimulations of the rostral pons caused premature terminations and/or onsets of phrenic activity in eupnea. Electrolytic lesions of rostrolateral pons resulted in apneusis, characterized by significant prolongations of the phrenic burst. Some effective lesions were in the region of the nucleus parabrachialis medialis and the Kolliker-Fuse nucleus, the site of the pneumotaxic center. Other lesions resulting in apneusis were ventral to the pneumotaxic center. As in cats, lesions in the caudal pontile reticular formation caused the duration of the apneustic neural inspiration to return toward that of eupnea. Again, as in other species, gradual alterations from eupnea to gasping in the rat were recorded during hypoxia, which was induced by ventilation with carbon monoxide. We conclude that the brain stem respiratory control system is similarly organized in rats and other mammalian species. These results have implications for contemporary hypotheses concerning the neurogenesis of ventilatory activity. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Applied Physiology | en_US |
dc.subject | apneusis | - |
dc.subject | control of respiration | - |
dc.subject | eupnea | - |
dc.subject | pneumotaxic center | - |
dc.subject | vagi | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anoxia - Physiopathology | en_US |
dc.subject.mesh | Brain Stem - Anatomy & Histology - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Ketamine - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pons - Anatomy & Histology - Physiology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Respiration - Drug Effects - Physiology | en_US |
dc.subject.mesh | Respiratory Center - Anatomy & Histology - Physiology | en_US |
dc.subject.mesh | Species Specificity | en_US |
dc.subject.mesh | Vagotomy | en_US |
dc.subject.mesh | Vagus Nerve - Physiology | en_US |
dc.title | Pontile regulation of ventilatory activity in the adult rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fung, ML:fungml@hkucc.hku.hk | en_US |
dc.identifier.authority | Fung, ML=rp00433 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 8365984 | - |
dc.identifier.scopus | eid_2-s2.0-0027318688 | en_US |
dc.identifier.volume | 74 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 2801 | en_US |
dc.identifier.epage | 2811 | en_US |
dc.identifier.isi | WOS:A1993LL82000028 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wang, W=7501756233 | en_US |
dc.identifier.scopusauthorid | Fung, ML=7101955092 | en_US |
dc.identifier.scopusauthorid | St John, WM=36831054200 | en_US |
dc.identifier.issnl | 1522-1601 | - |