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Article: Pontile regulation of ventilatory activity in the adult rat

TitlePontile regulation of ventilatory activity in the adult rat
Authors
Issue Date1993
Citation
Journal Of Applied Physiology, 1993, v. 74 n. 6, p. 2801-2811 How to Cite?
AbstractOur purpose was to characterize the pontile components of the brain stem ventilatory control system in rats. This study was precipitated by reports that this pontile component might differ fundamentally from that of other species. Efferent activity of the phrenic nerve was recorded in anesthetized, vagotomized, paralyzed, and ventilated adult rats. As in other species, electrical stimulations of the rostral pons caused premature terminations and/or onsets of phrenic activity in eupnea. Electrolytic lesions of rostrolateral pons resulted in apneusis, characterized by significant prolongations of the phrenic burst. Some effective lesions were in the region of the nucleus parabrachialis medialis and the Kolliker-Fuse nucleus, the site of the pneumotaxic center. Other lesions resulting in apneusis were ventral to the pneumotaxic center. As in cats, lesions in the caudal pontile reticular formation caused the duration of the apneustic neural inspiration to return toward that of eupnea. Again, as in other species, gradual alterations from eupnea to gasping in the rat were recorded during hypoxia, which was induced by ventilation with carbon monoxide. We conclude that the brain stem respiratory control system is similarly organized in rats and other mammalian species. These results have implications for contemporary hypotheses concerning the neurogenesis of ventilatory activity.
Persistent Identifierhttp://hdl.handle.net/10722/171583
ISSN
2015 Impact Factor: 3.004
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Wen_US
dc.contributor.authorFung, MLen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:15:49Z-
dc.date.available2012-10-30T06:15:49Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Applied Physiology, 1993, v. 74 n. 6, p. 2801-2811en_US
dc.identifier.issn8750-7587en_US
dc.identifier.urihttp://hdl.handle.net/10722/171583-
dc.description.abstractOur purpose was to characterize the pontile components of the brain stem ventilatory control system in rats. This study was precipitated by reports that this pontile component might differ fundamentally from that of other species. Efferent activity of the phrenic nerve was recorded in anesthetized, vagotomized, paralyzed, and ventilated adult rats. As in other species, electrical stimulations of the rostral pons caused premature terminations and/or onsets of phrenic activity in eupnea. Electrolytic lesions of rostrolateral pons resulted in apneusis, characterized by significant prolongations of the phrenic burst. Some effective lesions were in the region of the nucleus parabrachialis medialis and the Kolliker-Fuse nucleus, the site of the pneumotaxic center. Other lesions resulting in apneusis were ventral to the pneumotaxic center. As in cats, lesions in the caudal pontile reticular formation caused the duration of the apneustic neural inspiration to return toward that of eupnea. Again, as in other species, gradual alterations from eupnea to gasping in the rat were recorded during hypoxia, which was induced by ventilation with carbon monoxide. We conclude that the brain stem respiratory control system is similarly organized in rats and other mammalian species. These results have implications for contemporary hypotheses concerning the neurogenesis of ventilatory activity.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshBrain Stem - Anatomy & Histology - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshKetamine - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPons - Anatomy & Histology - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRespiration - Drug Effects - Physiologyen_US
dc.subject.meshRespiratory Center - Anatomy & Histology - Physiologyen_US
dc.subject.meshSpecies Specificityen_US
dc.subject.meshVagotomyen_US
dc.subject.meshVagus Nerve - Physiologyen_US
dc.titlePontile regulation of ventilatory activity in the adult raten_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8365984-
dc.identifier.scopuseid_2-s2.0-0027318688en_US
dc.identifier.volume74en_US
dc.identifier.issue6en_US
dc.identifier.spage2801en_US
dc.identifier.epage2811en_US
dc.identifier.isiWOS:A1993LL82000028-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, W=7501756233en_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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