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Article: Calcium mobilization by dual receptors during fertilization of sea urchin eggs

TitleCalcium mobilization by dual receptors during fertilization of sea urchin eggs
Authors
Issue Date1993
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1993, v. 261 n. 5119, p. 352-355 How to Cite?
AbstractFertilization is accompanied by a transient increase in the concentration of intracellular Ca2+, which serves as a signal for initiating development. Some of the Ca2+ appears to be released from intracellular stores by the binding of inositol trisphosphate (IP3) to its receptor. However, in sea urchin eggs, other mechanisms appear to participate. Cyclic adenosine diphosphate-ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide, is as potent as IP3 in mobilizing Ca2+ in sea urchin eggs. Experiments with antagonists of the cADPR and IP3 receptors revealed that both Ca2+ mobilizing systems were activated during fertilization. Blockage of either of the systems alone was not sufficient to prevent the sperm-induced Ca2+ transient. This study provides direct evidence for a physiological role of cADPR in the Ca2+ signaling process.
Persistent Identifierhttp://hdl.handle.net/10722/171579
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHon Cheung Leeen_US
dc.contributor.authorAarhus, Ren_US
dc.contributor.authorWalseth, TFen_US
dc.date.accessioned2012-10-30T06:15:48Z-
dc.date.available2012-10-30T06:15:48Z-
dc.date.issued1993en_US
dc.identifier.citationScience, 1993, v. 261 n. 5119, p. 352-355en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/171579-
dc.description.abstractFertilization is accompanied by a transient increase in the concentration of intracellular Ca2+, which serves as a signal for initiating development. Some of the Ca2+ appears to be released from intracellular stores by the binding of inositol trisphosphate (IP3) to its receptor. However, in sea urchin eggs, other mechanisms appear to participate. Cyclic adenosine diphosphate-ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide, is as potent as IP3 in mobilizing Ca2+ in sea urchin eggs. Experiments with antagonists of the cADPR and IP3 receptors revealed that both Ca2+ mobilizing systems were activated during fertilization. Blockage of either of the systems alone was not sufficient to prevent the sperm-induced Ca2+ transient. This study provides direct evidence for a physiological role of cADPR in the Ca2+ signaling process.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAdenosine Diphosphate Ribose - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCalcium Channelsen_US
dc.subject.meshCyclic Adp-Riboseen_US
dc.subject.meshCyclic Amp - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilizationen_US
dc.subject.meshHeparin - Pharmacologyen_US
dc.subject.meshInositol 1,4,5-Trisphosphate - Pharmacologyen_US
dc.subject.meshInositol 1,4,5-Trisphosphate Receptorsen_US
dc.subject.meshOvum - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Physiologyen_US
dc.subject.meshReceptors, Cytoplasmic And Nuclearen_US
dc.subject.meshSea Urchinsen_US
dc.subject.meshSignal Transductionen_US
dc.titleCalcium mobilization by dual receptors during fertilization of sea urchin eggsen_US
dc.typeArticleen_US
dc.identifier.emailHon Cheung Lee:leehc@hku.hken_US
dc.identifier.authorityHon Cheung Lee=rp00545en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.8392749-
dc.identifier.pmid8392749-
dc.identifier.scopuseid_2-s2.0-0027295646en_US
dc.identifier.volume261en_US
dc.identifier.issue5119en_US
dc.identifier.spage352en_US
dc.identifier.epage355en_US
dc.identifier.isiWOS:A1993LM67800036-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHon Cheung Lee=26642959100en_US
dc.identifier.scopusauthoridAarhus, R=6701339421en_US
dc.identifier.scopusauthoridWalseth, TF=7005424273en_US

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