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Article: Norepinephrine release in rat vas deferens. Effect of rauwolscine and BHT 920

TitleNorepinephrine release in rat vas deferens. Effect of rauwolscine and BHT 920
Authors
Issue Date1993
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1993, v. 53 n. 2, p. PL-19-PL-24 How to Cite?
AbstractNorepinephrine (NE) overflow from field-stimulated rat vas deferens preparations was quantified directly by electrochemical detection using high performance high liquid chromatography. The effect of agonist (BHT 920) and antagonist (rauwolscine) of prejunctional α2-adrenoceptors on NE overflow was assessed and compared with their effect on the smooth muscle mechanical response to field stimulation. Increasing the stimulation frequency from 2 to 30 Hz resulted in an increase in muscle tension together with an increase in NE overflow. Addition of 1 μM rauwolscine to the medium resulted in a significant increase in muscle contraction to field stimulation which reached a maximum at 5 Hz. On the other hand, NE overflow increased linearly with the frequency of stimulation within the range studied. Addition of 0.1 μM BHT 920 to the medium significantly decreased the amplitude of contractions at lower stimulation frequencies (2 to 10 Hz) but elicited no significant changes at high frequencies. BHT 920 did not significantly affect NE overflow for all range of stimulation frequency. The simultaneous recording of field-stimulation induced contractions and NE overflow indicates that in the rat vas deferens, rauwolscine acts like a pure α2 adrenoceptor antagonist at a prejunctional level. BHT 920 did not appear to affect selectively prejunctional α2 adrenoceptors but also may activate postjunctional α1 adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/171578
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLapierre, Nen_US
dc.contributor.authorWilson, Jen_US
dc.contributor.authorBourreau, JPen_US
dc.contributor.authorTougas, Gen_US
dc.contributor.authorKwan, CYen_US
dc.contributor.authorDaniel, EEen_US
dc.date.accessioned2012-10-30T06:15:47Z-
dc.date.available2012-10-30T06:15:47Z-
dc.date.issued1993en_US
dc.identifier.citationLife Sciences, 1993, v. 53 n. 2, p. PL-19-PL-24en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/171578-
dc.description.abstractNorepinephrine (NE) overflow from field-stimulated rat vas deferens preparations was quantified directly by electrochemical detection using high performance high liquid chromatography. The effect of agonist (BHT 920) and antagonist (rauwolscine) of prejunctional α2-adrenoceptors on NE overflow was assessed and compared with their effect on the smooth muscle mechanical response to field stimulation. Increasing the stimulation frequency from 2 to 30 Hz resulted in an increase in muscle tension together with an increase in NE overflow. Addition of 1 μM rauwolscine to the medium resulted in a significant increase in muscle contraction to field stimulation which reached a maximum at 5 Hz. On the other hand, NE overflow increased linearly with the frequency of stimulation within the range studied. Addition of 0.1 μM BHT 920 to the medium significantly decreased the amplitude of contractions at lower stimulation frequencies (2 to 10 Hz) but elicited no significant changes at high frequencies. BHT 920 did not significantly affect NE overflow for all range of stimulation frequency. The simultaneous recording of field-stimulation induced contractions and NE overflow indicates that in the rat vas deferens, rauwolscine acts like a pure α2 adrenoceptor antagonist at a prejunctional level. BHT 920 did not appear to affect selectively prejunctional α2 adrenoceptors but also may activate postjunctional α1 adrenoceptors.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAzepines - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Innervationen_US
dc.subject.meshNorepinephrine - Secretionen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshVas Deferens - Drug Effects - Innervationen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleNorepinephrine release in rat vas deferens. Effect of rauwolscine and BHT 920en_US
dc.typeArticleen_US
dc.identifier.emailBourreau, JP:bourreau@hkucc.hku.hken_US
dc.identifier.authorityBourreau, JP=rp00389en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0024-3205(93)90666-Q-
dc.identifier.pmid8100039-
dc.identifier.scopuseid_2-s2.0-0027263115en_US
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.spagePLen_US
dc.identifier.epage19en_US
dc.identifier.isiWOS:A1993LF44100012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLaPierre, N=10241646400en_US
dc.identifier.scopusauthoridWilson, J=10239102200en_US
dc.identifier.scopusauthoridBourreau, JP=7003927886en_US
dc.identifier.scopusauthoridTougas, G=7006829238en_US
dc.identifier.scopusauthoridKwan, CY=7201421224en_US
dc.identifier.scopusauthoridDaniel, EE=35474017600en_US

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