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Article: Decrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease

TitleDecrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease
Authors
Issue Date1992
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1992, v. 599 n. 1, p. 175-180 How to Cite?
AbstractThe Wobbler mouse possesses an inherited motoneuron disease, which expresses itself primarily at cervical spinal levels and in cranial motor nuclei. Cell degeneration is sporatic and negligible in other motor regions of the brain (e.g., cerebellum, corpus striatum). However, enkephalin concentrations are consistently lower in the Wobbler cerebellum throughout the motoneuron disease, whereas substance P concentrations are significantly higher late in the disease compared with the normal phenotype littermates. The data imply that early changes in enkephalin (also shown for leucine enkephalin in the spinal cord and brainstem) may be important to the etiology of the Wobbler disorder. Like the late increase of substance P, this may reflect a yet-to-be described response to parent cell degeneration in the raphe nuclei. TRH remained unchanged in Wobbler cerebellum and corpus striatum, wherein the other peptides studied herein also maintained similar concentrations to the normal phenotype littermates.
Persistent Identifierhttp://hdl.handle.net/10722/171572
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYung, KKLen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorVaccaGalloway, LLen_US
dc.date.accessioned2012-10-30T06:15:44Z-
dc.date.available2012-10-30T06:15:44Z-
dc.date.issued1992en_US
dc.identifier.citationBrain Research, 1992, v. 599 n. 1, p. 175-180en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/171572-
dc.description.abstractThe Wobbler mouse possesses an inherited motoneuron disease, which expresses itself primarily at cervical spinal levels and in cranial motor nuclei. Cell degeneration is sporatic and negligible in other motor regions of the brain (e.g., cerebellum, corpus striatum). However, enkephalin concentrations are consistently lower in the Wobbler cerebellum throughout the motoneuron disease, whereas substance P concentrations are significantly higher late in the disease compared with the normal phenotype littermates. The data imply that early changes in enkephalin (also shown for leucine enkephalin in the spinal cord and brainstem) may be important to the etiology of the Wobbler disorder. Like the late increase of substance P, this may reflect a yet-to-be described response to parent cell degeneration in the raphe nuclei. TRH remained unchanged in Wobbler cerebellum and corpus striatum, wherein the other peptides studied herein also maintained similar concentrations to the normal phenotype littermates.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCerebellum - Metabolismen_US
dc.subject.meshCorpus Striatum - Metabolismen_US
dc.subject.meshEnkephalin, Leucine - Metabolismen_US
dc.subject.meshEnkephalin, Methionine - Metabolismen_US
dc.subject.meshEnkephalins - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Neurologic Mutantsen_US
dc.subject.meshMotor Neuron Disease - Genetics - Metabolism - Physiopathologyen_US
dc.subject.meshSubstance P - Metabolismen_US
dc.subject.meshThyrotropin-Releasing Hormone - Metabolismen_US
dc.titleDecrease of enkephalins in cerebellum during Wobbler mouse motoneuron diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-8993(92)90869-Ben_US
dc.identifier.pmid1283561-
dc.identifier.scopuseid_2-s2.0-0027049414en_US
dc.identifier.volume599en_US
dc.identifier.issue1en_US
dc.identifier.spage175en_US
dc.identifier.epage180en_US
dc.identifier.isiWOS:A1992KF96900026-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridYung, KKL=36840201600en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridVaccaGalloway, LL=6602468305en_US

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