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Article: Constant light exposure increases 2-[125I]iodomelatonin binding sites in the guinea pig spleen

TitleConstant light exposure increases 2-[125I]iodomelatonin binding sites in the guinea pig spleen
Authors
Issue Date1992
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1992, v. 146 n. 1, p. 41-44 How to Cite?
AbstractThe effect of constant light exposure on 2-[125I]iodomelatonin binding sites in the guinea pig spleen was investigated. Guinea pigs exposed to constant light for 2-3 weeks showed an increase in the number of splenic 2-[125I]iodomelatonin binding sites, without any difference in the binding affinity, in comparison to animals kept under 12 h light/12 h darkness condition, whereas the splenic indices were similar in both groups. This light dependence of the splenic 2-[125I]iodomelatonin binding sites suggests that the binding sites are melatonin receptors and that the light dependent immunomodulatory effect of melatonin is mediated via a direct action on the lymphoid tissue.
Persistent Identifierhttp://hdl.handle.net/10722/171565
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPoon, AMSen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:15:42Z-
dc.date.available2012-10-30T06:15:42Z-
dc.date.issued1992en_US
dc.identifier.citationNeuroscience Letters, 1992, v. 146 n. 1, p. 41-44en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/171565-
dc.description.abstractThe effect of constant light exposure on 2-[125I]iodomelatonin binding sites in the guinea pig spleen was investigated. Guinea pigs exposed to constant light for 2-3 weeks showed an increase in the number of splenic 2-[125I]iodomelatonin binding sites, without any difference in the binding affinity, in comparison to animals kept under 12 h light/12 h darkness condition, whereas the splenic indices were similar in both groups. This light dependence of the splenic 2-[125I]iodomelatonin binding sites suggests that the binding sites are melatonin receptors and that the light dependent immunomodulatory effect of melatonin is mediated via a direct action on the lymphoid tissue.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCircadian Rhythm - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshKineticsen_US
dc.subject.meshLighten_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Analogs & Derivatives - Metabolismen_US
dc.subject.meshReceptors, Melatoninen_US
dc.subject.meshReceptors, Neurotransmitter - Metabolism - Radiation Effectsen_US
dc.subject.meshSpleen - Metabolism - Radiation Effectsen_US
dc.titleConstant light exposure increases 2-[125I]iodomelatonin binding sites in the guinea pig spleenen_US
dc.typeArticleen_US
dc.identifier.emailPoon, AMS:amspoon@hkucc.hku.hken_US
dc.identifier.authorityPoon, AMS=rp00354en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(92)90167-6en_US
dc.identifier.pmid1335561-
dc.identifier.scopuseid_2-s2.0-0026437580en_US
dc.identifier.volume146en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage44en_US
dc.identifier.isiWOS:A1992JW56800011-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridPoon, AMS=7103068868en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US

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