File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1126/science.1909457
- Scopus: eid_2-s2.0-0026418298
- PMID: 1909457
- WOS: WOS:A1991GD80800034
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Ca2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-ribose
Title | Ca2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-ribose |
---|---|
Authors | |
Issue Date | 1991 |
Publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org |
Citation | Science, 1991, v. 253 n. 5024, p. 1143-1146 How to Cite? |
Abstract | Calcium-induced calcium release (CICR) may function widely in calcium-mediated cell signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of sea urchin eggs, which display transients in the intracellular free calcium concentration ([Ca2+]i) during fertilization and anaphase, addition of Ca2+ triggered CICR. Ca2+ release was also induced by the CICR modulators ryanodine and caffeine. Responses to both Ca2+ and CICR modulators (but not Ca2+ release mediated by inositol 1,4,5-trisphosphate) were inhibited by procaine and ruthenium red, inhibitors of CICR. Intact eggs also displayed transients of [Ca2+]i when microinjected with ryanodine. Cyclic ADP-ribose, a metabolite with potent Ca2+-releasing properties, appears to act by way of the CICR mechanism and may thus be an endogenous modulator of CICR. A CICR mechanism is present in these nonmuscle cells as is assumed in various models of intracellular Ca2+ wave propagation. |
Persistent Identifier | http://hdl.handle.net/10722/171564 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Galione, A | en_US |
dc.contributor.author | Lee, HC | en_US |
dc.contributor.author | Busa, WB | en_US |
dc.date.accessioned | 2012-10-30T06:15:42Z | - |
dc.date.available | 2012-10-30T06:15:42Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Science, 1991, v. 253 n. 5024, p. 1143-1146 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171564 | - |
dc.description.abstract | Calcium-induced calcium release (CICR) may function widely in calcium-mediated cell signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of sea urchin eggs, which display transients in the intracellular free calcium concentration ([Ca2+]i) during fertilization and anaphase, addition of Ca2+ triggered CICR. Ca2+ release was also induced by the CICR modulators ryanodine and caffeine. Responses to both Ca2+ and CICR modulators (but not Ca2+ release mediated by inositol 1,4,5-trisphosphate) were inhibited by procaine and ruthenium red, inhibitors of CICR. Intact eggs also displayed transients of [Ca2+]i when microinjected with ryanodine. Cyclic ADP-ribose, a metabolite with potent Ca2+-releasing properties, appears to act by way of the CICR mechanism and may thus be an endogenous modulator of CICR. A CICR mechanism is present in these nonmuscle cells as is assumed in various models of intracellular Ca2+ wave propagation. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org | en_US |
dc.relation.ispartof | Science | en_US |
dc.subject.mesh | Adenosine Diphosphate Ribose - Pharmacology | en_US |
dc.subject.mesh | Adenosine Triphosphate - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Cyclic Adp-Ribose | en_US |
dc.subject.mesh | Egtazic Acid - Pharmacology | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Ovum - Drug Effects - Physiology | en_US |
dc.subject.mesh | Sea Urchins | en_US |
dc.subject.mesh | Spectrometry, Fluorescence | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Ca2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-ribose | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, HC:leehc@hku.hk | en_US |
dc.identifier.authority | Lee, HC=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1126/science.1909457 | - |
dc.identifier.pmid | 1909457 | en_US |
dc.identifier.scopus | eid_2-s2.0-0026418298 | en_US |
dc.identifier.volume | 253 | en_US |
dc.identifier.issue | 5024 | en_US |
dc.identifier.spage | 1143 | en_US |
dc.identifier.epage | 1146 | en_US |
dc.identifier.isi | WOS:A1991GD80800034 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Galione, A=7006334937 | en_US |
dc.identifier.scopusauthorid | Lee, HC=26642959100 | en_US |
dc.identifier.scopusauthorid | Busa, WB=6603916520 | en_US |
dc.identifier.issnl | 0036-8075 | - |