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Article: Intracerebroventricular atrial natriuretic factor (ANF) antiserum inhibits volume-induced ANF in sheep: Evidence for the brain's regulation of ANF secretion

TitleIntracerebroventricular atrial natriuretic factor (ANF) antiserum inhibits volume-induced ANF in sheep: Evidence for the brain's regulation of ANF secretion
Authors
Issue Date1991
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1991, v. 129 n. 4, p. 2225-2230 How to Cite?
AbstractPlasma volume expansion stimulates cardiac secretion of atrial natriuretic factor (ANF) and also increases the ANF concentration in cerebrospinal fluid. In order to determine whether brain ANF is involved in the compensatory response to hypervolemia or the regulation of cardiac secretion of ANF, we have studied the integrated hemodynamic, renal, and hormonal response to acute volume expansion (15 ml/kg Dextran over 30 min) in five sheep given nonimmune serum (control) and ANF antiserum by intracerebroventricular (icv) injections on separate days. Dextran loading caused similar decreases in hematocrit and increases in central venous and mean arterial pressures on both study days. Heart rate was higher after antiserum injections (P < 0.05). Dextran loading increased plasma ANF on the control (20 pmol/liter maximal mean increment above baseline) but not on the antiserum day (P < 0.01). The diuresis (P < 0.01) and natriuresis (P < 0.05) observed on the control day was inhibited by icv antiserum. Plasma aldosterone and cortisol levels showed similar falls in response to the dextran load on both days. These experiments show that icv ANF antiserum inhibits both the increase in cardiac secretion of ANF and the renal response to plasma volume expansion without affecting hemodynamic status. These data support the hypothesis that the brain ANF system is important in the systemic responses to volume loading.
Persistent Identifierhttp://hdl.handle.net/10722/171561
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCharles, CJen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorCameron, VAen_US
dc.contributor.authorRichards, AMen_US
dc.contributor.authorEspiner, EAen_US
dc.date.accessioned2012-10-30T06:15:41Z-
dc.date.available2012-10-30T06:15:41Z-
dc.date.issued1991en_US
dc.identifier.citationEndocrinology, 1991, v. 129 n. 4, p. 2225-2230en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/171561-
dc.description.abstractPlasma volume expansion stimulates cardiac secretion of atrial natriuretic factor (ANF) and also increases the ANF concentration in cerebrospinal fluid. In order to determine whether brain ANF is involved in the compensatory response to hypervolemia or the regulation of cardiac secretion of ANF, we have studied the integrated hemodynamic, renal, and hormonal response to acute volume expansion (15 ml/kg Dextran over 30 min) in five sheep given nonimmune serum (control) and ANF antiserum by intracerebroventricular (icv) injections on separate days. Dextran loading caused similar decreases in hematocrit and increases in central venous and mean arterial pressures on both study days. Heart rate was higher after antiserum injections (P < 0.05). Dextran loading increased plasma ANF on the control (20 pmol/liter maximal mean increment above baseline) but not on the antiserum day (P < 0.01). The diuresis (P < 0.01) and natriuresis (P < 0.05) observed on the control day was inhibited by icv antiserum. Plasma aldosterone and cortisol levels showed similar falls in response to the dextran load on both days. These experiments show that icv ANF antiserum inhibits both the increase in cardiac secretion of ANF and the renal response to plasma volume expansion without affecting hemodynamic status. These data support the hypothesis that the brain ANF system is important in the systemic responses to volume loading.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshAldosterone - Blooden_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtrial Natriuretic Factor - Blood - Immunology - Metabolismen_US
dc.subject.meshBlood Volume - Physiologyen_US
dc.subject.meshBrain - Physiologyen_US
dc.subject.meshDextrans - Pharmacologyen_US
dc.subject.meshDiuresisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematocriten_US
dc.subject.meshImmune Sera - Physiologyen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshNatriuresisen_US
dc.subject.meshRabbits - Blooden_US
dc.subject.meshSheepen_US
dc.titleIntracerebroventricular atrial natriuretic factor (ANF) antiserum inhibits volume-induced ANF in sheep: Evidence for the brain's regulation of ANF secretionen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/endo-129-4-2225-
dc.identifier.pmid1717243-
dc.identifier.scopuseid_2-s2.0-0026091788en_US
dc.identifier.volume129en_US
dc.identifier.issue4en_US
dc.identifier.spage2225en_US
dc.identifier.epage2230en_US
dc.identifier.isiWOS:A1991GH33600074-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCharles, CJ=7102123182en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridCameron, VA=7006755240en_US
dc.identifier.scopusauthoridRichards, AM=7402299599en_US
dc.identifier.scopusauthoridEspiner, EA=7102138126en_US

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