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Article: Patterns of pineal melatonin secretion in rabbits: Diurnal variation of basal and pulsatile release

TitlePatterns of pineal melatonin secretion in rabbits: Diurnal variation of basal and pulsatile release
Authors
Issue Date1990
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 1990, v. 51 n. 2, p. 147-155 How to Cite?
AbstractThe level and release pattern of plasma melatonin in the confluens sinuum of 28 sighted and 18 blinded (i.e. acute bilateral orbital enucleation) rabbits anesthetized with penobarbital were studied. The animals had been adapted to a 12:12 h light-dark regime. Blood samples were collected from the cannulated confluens sinuum and/or the femoral artery at either 2- or 4-min intervals in both the light and dark phases. Plasma melatonin was determined by radioimmunoassay. In all rabbits studied, plasma melatonin in the confluens sinuum exhibited an episodic release pattern, with pulses superimposed on a basal level. At 4-min sampling intervals, the pulsatile release of melatonin in sighted rabbits were 3.8 peaks/h in the light phase; shorter sampling interval (2-min) revealed more frequent pulsatile release of melatonin (5.1 peaks/h). In sighted animals in the light phase, the level of melatonin in the plasma of confluens sinuum was 7-15 times higher than that obtained from the plasma collected at the same time from the peripheral artery where the level of melatonin also exhibited pulsatile pattern. In blinded animals, melatonin levels in terms of mean concentration, mean maximum level and mean minimum (or baseline) level obtained in the dark phase were 12-14 times higher than those obtained in the light phase. These results suggest that the level of melatonin exhibits a diurnal rhythm in the confluens sinuum of rabbits.
Persistent Identifierhttp://hdl.handle.net/10722/171541
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_US
dc.contributor.authorCheung, YMen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:15:36Z-
dc.date.available2012-10-30T06:15:36Z-
dc.date.issued1990en_US
dc.identifier.citationNeuroendocrinology, 1990, v. 51 n. 2, p. 147-155en_US
dc.identifier.issn0028-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/171541-
dc.description.abstractThe level and release pattern of plasma melatonin in the confluens sinuum of 28 sighted and 18 blinded (i.e. acute bilateral orbital enucleation) rabbits anesthetized with penobarbital were studied. The animals had been adapted to a 12:12 h light-dark regime. Blood samples were collected from the cannulated confluens sinuum and/or the femoral artery at either 2- or 4-min intervals in both the light and dark phases. Plasma melatonin was determined by radioimmunoassay. In all rabbits studied, plasma melatonin in the confluens sinuum exhibited an episodic release pattern, with pulses superimposed on a basal level. At 4-min sampling intervals, the pulsatile release of melatonin in sighted rabbits were 3.8 peaks/h in the light phase; shorter sampling interval (2-min) revealed more frequent pulsatile release of melatonin (5.1 peaks/h). In sighted animals in the light phase, the level of melatonin in the plasma of confluens sinuum was 7-15 times higher than that obtained from the plasma collected at the same time from the peripheral artery where the level of melatonin also exhibited pulsatile pattern. In blinded animals, melatonin levels in terms of mean concentration, mean maximum level and mean minimum (or baseline) level obtained in the dark phase were 12-14 times higher than those obtained in the light phase. These results suggest that the level of melatonin exhibits a diurnal rhythm in the confluens sinuum of rabbits.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_US
dc.relation.ispartofNeuroendocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlindness - Blood - Physiopathologyen_US
dc.subject.meshCircadian Rhythm - Physiologyen_US
dc.subject.meshDarknessen_US
dc.subject.meshFemaleen_US
dc.subject.meshLighten_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Blood - Secretionen_US
dc.subject.meshPineal Gland - Secretionen_US
dc.subject.meshRabbitsen_US
dc.titlePatterns of pineal melatonin secretion in rabbits: Diurnal variation of basal and pulsatile releaseen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000125330-
dc.identifier.pmid2106095-
dc.identifier.scopuseid_2-s2.0-0025008882en_US
dc.identifier.volume51en_US
dc.identifier.issue2en_US
dc.identifier.spage147en_US
dc.identifier.epage155en_US
dc.identifier.isiWOS:A1990CL40600005-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridCheung, YM=24521372000en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US

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