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- Publisher Website: 10.1111/j.1440-1681.1989.tb01609.x
- Scopus: eid_2-s2.0-0024465152
- PMID: 2805432
- WOS: WOS:A1989AP58000005
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Article: Effects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat heart
Title | Effects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat heart |
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Authors | |
Keywords | catecholamines enkephalins ischaemia isolated rat heart noradrenaline reperfusion reserpine |
Issue Date | 1989 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 7, p. 591-596 How to Cite? |
Abstract | 1. The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion. |
Persistent Identifier | http://hdl.handle.net/10722/171533 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhan, CY | en_US |
dc.contributor.author | Tang, F | en_US |
dc.contributor.author | Lee, AYS | en_US |
dc.contributor.author | Wong, TM | en_US |
dc.date.accessioned | 2012-10-30T06:15:34Z | - |
dc.date.available | 2012-10-30T06:15:34Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 7, p. 591-596 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171533 | - |
dc.description.abstract | 1. The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | catecholamines | - |
dc.subject | enkephalins | - |
dc.subject | ischaemia | - |
dc.subject | isolated rat heart | - |
dc.subject | noradrenaline | - |
dc.subject | reperfusion | - |
dc.subject | reserpine | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arrhythmias, Cardiac - Etiology - Prevention & Control | en_US |
dc.subject.mesh | Catecholamines - Physiology | en_US |
dc.subject.mesh | Chromatography, High Pressure Liquid | en_US |
dc.subject.mesh | Coronary Disease - Complications - Physiopathology | en_US |
dc.subject.mesh | Enkephalins - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Myocardial Reperfusion Injury - Complications - Physiopathology | en_US |
dc.subject.mesh | Myocardium - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Reserpine - Pharmacology | en_US |
dc.title | Effects of reserpine treatment on arrhythmogenesis during ischaemia and reperfusion in the isolated rat heart | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, F:ftang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, F=rp00327 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1989.tb01609.x | - |
dc.identifier.pmid | 2805432 | - |
dc.identifier.scopus | eid_2-s2.0-0024465152 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 591 | en_US |
dc.identifier.epage | 596 | en_US |
dc.identifier.isi | WOS:A1989AP58000005 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Zhan, CY=36967038400 | en_US |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_US |
dc.identifier.scopusauthorid | Lee, AYS=51764125700 | en_US |
dc.identifier.scopusauthorid | Wong, TM=7403531434 | en_US |
dc.identifier.issnl | 0305-1870 | - |