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Article: Changes in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapy

TitleChanges in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapy
Authors
Issue Date1989
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 2, p. 65-75 How to Cite?
AbstractImmunoreactive (IR)-met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary were measured in alloxan-diabetic rats with or without insulin treatment. Both IR-met-enkephalin and IR-β-endorphin in the pituitary were substantially reduced in alloxan-diabetic rats 1 month after treatment. Hypothalamic IR-β-endorphin content was also significantly lower. Gel-filtration chromatography showed that the peaks co-eluting with met-enkephalin precursor, met-enkephalin and β-endorphin were lower in the pituitaries from the diabetic rats, whereas the peaks co-eluting with β-endorphin precursor and β-lipotropin were not. In another experiment, the IR-β-endorphin contents of the neuro-intermediate lobe and hypothalamus, but not the anterior lobe were significantly lowered in diabetic rats, whereas IR-met-enkephalin contents were significantly reduced in both the anterior and neuro-intermediate lobe. All these changes were reversed by insulin treatment. As a decrease in general protein synthesis could not explain the recorded changes, these results suggest a possible direct role of insulin in regulating the opioid peptide content of the hypothalamus and pituitary.
Persistent Identifierhttp://hdl.handle.net/10722/171531
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:15:33Z-
dc.date.available2012-10-30T06:15:33Z-
dc.date.issued1989en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1989, v. 16 n. 2, p. 65-75en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171531-
dc.description.abstractImmunoreactive (IR)-met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary were measured in alloxan-diabetic rats with or without insulin treatment. Both IR-met-enkephalin and IR-β-endorphin in the pituitary were substantially reduced in alloxan-diabetic rats 1 month after treatment. Hypothalamic IR-β-endorphin content was also significantly lower. Gel-filtration chromatography showed that the peaks co-eluting with met-enkephalin precursor, met-enkephalin and β-endorphin were lower in the pituitaries from the diabetic rats, whereas the peaks co-eluting with β-endorphin precursor and β-lipotropin were not. In another experiment, the IR-β-endorphin contents of the neuro-intermediate lobe and hypothalamus, but not the anterior lobe were significantly lowered in diabetic rats, whereas IR-met-enkephalin contents were significantly reduced in both the anterior and neuro-intermediate lobe. All these changes were reversed by insulin treatment. As a decrease in general protein synthesis could not explain the recorded changes, these results suggest a possible direct role of insulin in regulating the opioid peptide content of the hypothalamus and pituitary.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshChromatography, Gelen_US
dc.subject.meshDiabetes Mellitus, Experimental - Drug Therapy - Metabolismen_US
dc.subject.meshEnkephalin, Methionine - Analysis - Metabolismen_US
dc.subject.meshHypothalamus - Metabolismen_US
dc.subject.meshInsulin - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshOrgan Size - Drug Effectsen_US
dc.subject.meshPituitary Gland - Metabolismen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshBeta-Endorphin - Analysis - Metabolismen_US
dc.titleChanges in met-enkephalin and β-endorphin contents in the hypothalamus and the pituitary in diabetic rats: Effects of insulin therapyen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1989.tb01530.x-
dc.identifier.pmid2523766-
dc.identifier.scopuseid_2-s2.0-0024437211en_US
dc.identifier.volume16en_US
dc.identifier.issue2en_US
dc.identifier.spage65en_US
dc.identifier.epage75en_US
dc.identifier.isiWOS:A1989U211800001-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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