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Article: Hypothyroidism and pituitary contents of immunoactive met-enkephalin and β-endorphin in male rats of different ages

TitleHypothyroidism and pituitary contents of immunoactive met-enkephalin and β-endorphin in male rats of different ages
Authors
Issue Date1988
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1988, v. 188 n. 1, p. 82-86 How to Cite?
AbstractA comparison of the effect of PTU-induced hypothyroidism on the contents of immunoactive met-enkephalin and β-endorphin in the pituitaries from rats aged 2 1/2 , 12, and 18 months was made. In all ages, there was significant reduction of IR-met-enkephalin content in the anterior lobe and IR-β-endorphin content in the neuro-intermediate lobe after PTU treatment. There was a significant age-related decrease in IR-β-endorphin content in the anterior lobe. Rats of all three ages responsed to PTU treatment with an increase in serum TSH level and a drastic reduction in serum T3 and T4 levels. The results indicate that there was no age-related difference in the change of pituitary opioid peptide contents in response to hypothyroidism.
Persistent Identifierhttp://hdl.handle.net/10722/171523
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorMan, SYen_US
dc.date.accessioned2012-10-30T06:15:32Z-
dc.date.available2012-10-30T06:15:32Z-
dc.date.issued1988en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1988, v. 188 n. 1, p. 82-86en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/171523-
dc.description.abstractA comparison of the effect of PTU-induced hypothyroidism on the contents of immunoactive met-enkephalin and β-endorphin in the pituitaries from rats aged 2 1/2 , 12, and 18 months was made. In all ages, there was significant reduction of IR-met-enkephalin content in the anterior lobe and IR-β-endorphin content in the neuro-intermediate lobe after PTU treatment. There was a significant age-related decrease in IR-β-endorphin content in the anterior lobe. Rats of all three ages responsed to PTU treatment with an increase in serum TSH level and a drastic reduction in serum T3 and T4 levels. The results indicate that there was no age-related difference in the change of pituitary opioid peptide contents in response to hypothyroidism.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAgingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnkephalin, Methionine - Analysisen_US
dc.subject.meshHypothyroidism - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Analysisen_US
dc.subject.meshRatsen_US
dc.subject.meshThyrotropin - Blooden_US
dc.subject.meshThyroxine - Blooden_US
dc.subject.meshTriiodothyronine - Blooden_US
dc.subject.meshBeta-Endorphin - Analysisen_US
dc.titleHypothyroidism and pituitary contents of immunoactive met-enkephalin and β-endorphin in male rats of different agesen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2966963-
dc.identifier.scopuseid_2-s2.0-0023904724en_US
dc.identifier.volume188en_US
dc.identifier.issue1en_US
dc.identifier.spage82en_US
dc.identifier.epage86en_US
dc.identifier.isiWOS:A1988N357700013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridMan, SY=7103398069en_US

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