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Article: Changes in adenosine release and blood flow in the contracting dog gracilis muscle

TitleChanges in adenosine release and blood flow in the contracting dog gracilis muscle
Authors
Issue Date1988
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htm
Citation
Pflugers Archiv European Journal Of Physiology, 1988, v. 412 n. 1-2, p. 106-112 How to Cite?
AbstractIschaemic contraction of skeletal muscle increases the venous concentration of adenosine. The present investigation was undertaken to determine changes in blood flow and the release of adenosine into venous blood resulting from 5 min of free flow contractions of the isolated gracilis muscle in dogs anaesthetised with pentobarbitone sodium (42 mg · kg-1) and artificially ventilated. Arterial and venous concentrations of adenosine were measured by high performance liquid chromatography. Five-minute-contractions (induced electrically, 6 V, 1.8 ms, 4 Hz) caused significant increases in blood flow (to 304 ± 33% of control; mean ± SEM, n = 9) and venous plasma adenosine concentration (from 126 ± 18 nM to 293 ± 76 nM, equivalent to an average increase in release of 7.28 ± 1.89 nmol · min-1 100 g-1 we weight of muscle). The venous oxygen tension decreased from 8.33 ± 0.48 to 3.39 ± 0.31 kPa (62.5 ± 3.6 to 25.4 ± 2.3 mm Hg). This small but significant increase in venous adenosine concentration within the vasoactive range, in the face of a concomitant increase in blood flow, suggests that an increase in the interstitial adenosine concentration during free-flow exercise may contribute to the total dilatation of the resistance vessels to increase blood flow and keep its own concentration low. A significant correlation between venous adenosine concentration and vascular conductance is therefore absent. The results suggest that adenosine may contribute to sustained active hyperaemia in skeletal muscle.
Persistent Identifierhttp://hdl.handle.net/10722/171522
ISSN
2015 Impact Factor: 3.654
2015 SCImago Journal Rankings: 1.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKarim, Fen_US
dc.contributor.authorBallard, HJen_US
dc.contributor.authorCotterrell, Den_US
dc.date.accessioned2012-10-30T06:15:31Z-
dc.date.available2012-10-30T06:15:31Z-
dc.date.issued1988en_US
dc.identifier.citationPflugers Archiv European Journal Of Physiology, 1988, v. 412 n. 1-2, p. 106-112en_US
dc.identifier.issn0031-6768en_US
dc.identifier.urihttp://hdl.handle.net/10722/171522-
dc.description.abstractIschaemic contraction of skeletal muscle increases the venous concentration of adenosine. The present investigation was undertaken to determine changes in blood flow and the release of adenosine into venous blood resulting from 5 min of free flow contractions of the isolated gracilis muscle in dogs anaesthetised with pentobarbitone sodium (42 mg · kg-1) and artificially ventilated. Arterial and venous concentrations of adenosine were measured by high performance liquid chromatography. Five-minute-contractions (induced electrically, 6 V, 1.8 ms, 4 Hz) caused significant increases in blood flow (to 304 ± 33% of control; mean ± SEM, n = 9) and venous plasma adenosine concentration (from 126 ± 18 nM to 293 ± 76 nM, equivalent to an average increase in release of 7.28 ± 1.89 nmol · min-1 100 g-1 we weight of muscle). The venous oxygen tension decreased from 8.33 ± 0.48 to 3.39 ± 0.31 kPa (62.5 ± 3.6 to 25.4 ± 2.3 mm Hg). This small but significant increase in venous adenosine concentration within the vasoactive range, in the face of a concomitant increase in blood flow, suggests that an increase in the interstitial adenosine concentration during free-flow exercise may contribute to the total dilatation of the resistance vessels to increase blood flow and keep its own concentration low. A significant correlation between venous adenosine concentration and vascular conductance is therefore absent. The results suggest that adenosine may contribute to sustained active hyperaemia in skeletal muscle.en_US
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htmen_US
dc.relation.ispartofPflugers Archiv European Journal of Physiologyen_US
dc.subject.meshAdenosine - Blood - Secretionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Flow Velocity - Drug Effectsen_US
dc.subject.meshBlood Gas Analysisen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshDogsen_US
dc.subject.meshFemur - Anatomy & Histologyen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscles - Blood Supplyen_US
dc.subject.meshTime Factorsen_US
dc.titleChanges in adenosine release and blood flow in the contracting dog gracilis muscleen_US
dc.typeArticleen_US
dc.identifier.emailBallard, HJ:ballard@hkucc.hku.hken_US
dc.identifier.authorityBallard, HJ=rp00367en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3174372-
dc.identifier.scopuseid_2-s2.0-0023875395en_US
dc.identifier.volume412en_US
dc.identifier.issue1-2en_US
dc.identifier.spage106en_US
dc.identifier.epage112en_US
dc.identifier.isiWOS:A1988P082900016-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridKarim, F=7005896790en_US
dc.identifier.scopusauthoridBallard, HJ=7005286310en_US
dc.identifier.scopusauthoridCotterrell, D=6602879005en_US

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